Protein arginine methylation
Protein Arginine Methylation in Parasitic Protozoa
... Protein arginine methylation generally alters protein func- tion by influencing protein-protein interactions, protein-nu- cleic acid interactions, and protein ...to ...
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Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport
... Protein arginine methylation plays a key role in numerous eukaryotic processes, such as protein transport and signal ...candidate protein arginine methyltransferases (PRMTs) have ...
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Protein arginine methylation: an emerging regulator of the cell cycle
... that protein arginine methylation is emerging as a key regulator of the cell cycle and may offer suitable targets for novel cancer drug development in the future, the immediate research effort should ...
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Protein arginine methylation/demethylation and cancer
... of arginine methylation in cancer, the development and validation of such drugs in clinical trials may represent the next challenge in this field of ...for arginine methylation, protein ...
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The Arginine-1493 Residue in QRRGRTGR1493G Motif IV of the Hepatitis C Virus NS3 Helicase Domain Is Essential for NS3 Protein Methylation by the Protein Arginine Methyltransferase 1
... whether arginine residues of the NS3 protein are methylated by ...of arginine resi- dues (22). Protein arginine methylation is an irreversible and posttranslational covalent ...
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From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases
... Abnormal protein arginine methylation triggers pathological changes in the lung. In the normal lung, methyl- arginines are generated via intracellular proteolysis and released to the intraalveolar, ...
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Protein Arginine Methyltransferases: from Unicellular Eukaryotes to Humans
... for protein arginine methylation was re- ported for Leishmania (71) and Trypanosoma (103) species, the evolutionary conservation of human PRMTs in unicellular eu- karyotes has not been thoroughly ...
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Queer Feelings, Political Potential: Tracing Affect in Performance Spaces
... mediated arginine methylation at micromolar potency through a unique mechanism: they directly target the substrates but not PRMT enzymes for the observed ...of protein arginine ...Arg-3 ...
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PubMedCentral-PMC5753604.pdf
... DNA methylation plays crucial roles in chromatin structure and gene ...DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in ...
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Arginine Methylation of Human Adenovirus Type 5 L4 100-Kilodalton Protein Is Required for Efficient Virus Production
... nonstructural protein (L4-100K) mediates inhibition of cellular protein synthesis and selective translation of tripartite leader (TL)-containing viral late mRNAs via ribosome ...hexon protein. We ...
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Organization of Plasmodium falciparum spliceosomal core complex and role of arginine methylation in its assembly
... ordered, protein-assisted process that involves two in- teracting units, SMN-complex and methyltransferase 7complex ...related protein TSN has recently been reported to participate in SnRNP ...
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Serological Reactivity and Biochemical Characterization of Methylated and Unmethylated Forms of a Recombinant Protein Fragment Derived from Outer Membrane Protein B of Rickettsia typhi
... after methylation was determined by both the precolumn ...alkylated protein was digested with 20 g trypsin (Promega, Madison, WI) overnight at ...digested protein sample (1 g) was loaded onto a ...
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Arginine Methylation of the ICP27 RGG Box Regulates the Functional Interactions of ICP27 with SRPK1 and Aly/REF during Herpes Simplex Virus 1 Infection
... by methylation on ar- ginine residues (10, 16). The major site of arginine methyl- ation, as determined by mass spectrometric analysis, is the RGG box from residues 138 to 152 ...Specifically, ...
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Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain
... 25. Wright, P.W., Bolling, L.C., Calvert, M.E., Sarmento, O.F., Berkeley, E.V., Shea, M.C., Hao, Z., Jayes, F.C., Bush, L.A., Shetty, J., Shore, A.N., Reddi, P.P., Tung, K.S., Samy, E., Allietta, M.M., Sherman, N.E., ...
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Entamoeba histolytica: protein arginine transferase 1a methylates arginine residues and potentially modify the H4 histone
... Arginine methylation is a posttranslational modification occurring in several cytoplasmic and nuclear proteins that modulates chromatin modification (leading to tran- scription activation or repression), ...
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Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription
... a protein that associates with mul- tiple DDB1-DCAF complexes ...the protein ar- ginine methyltransferase ...transcription, protein localization, and signal transduction (20) ...
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Hepatitis Delta Virus Antigen Is Methylated at Arginine Residues, and Methylation Regulates Subcellular Localization and RNA Replication
... single protein, hepatitis delta antigen ...by protein arginine methyltransferase (PRMT1) in vitro and in ...major methylation site is at arginine-13 (R13), which is in the RGGR motif of ...
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... Arginine methylation of Tat diminishes Tat-TAR binding affinity and Tat-TAR-cyclin T1 complex formation. Pro- karyotes do not contain any PRMTs (12). Therefore, to test the FIG. 2. PRMT6 affects Tat ...
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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
... and could be separated from the solution by gentle centri- fugation. The resultant pellet was subsequently washed and analyzed by gel electrophoresis (Figure 5A). Unexpectedly, this pellet was largely resistant to ...
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Implicated Role of Liposarcoma Related Fusion Oncoprotein TLS-CHOP in the Dysregulation of Arginine-Specific Methylation through PRMT1
... Whole cell extracts were prepared in RIPA buffer (50 mM Tris-HCl, pH 7.4, 150 mM NaCl, 0.25% deoxycholic acid, 1% NP-40, 1 mM EDTA). The cell extracts were incubated with FLAG-M2 agarose beads (Sigma-Aldrich) for 1 hour ...
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