protein degradation
Ruminal Protein Degradation and Estimation of Rumen Microbial Protein Production
... Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential ...
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A genetic bistable switch utilizing nonlinear protein degradation
... the protein production and degradation ...S.1.5). Degradation rates for CI remain the same without the extra feedback loop and the degradation curve remains completely ...the protein ...
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The different roles of selective autophagic protein degradation in mammalian cells
... bulk protein degradation and the removal of damaged organelles by ...mediated protein degradation is highly ...autophagic protein degradation has been associated with multiple ...
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A critical evaluation of the approaches to targeted protein degradation for drug discovery.
... and degradation, the scene was set for the investigation of mechanisms associated with proteolysis [reviewed by Ciechanover, ...manipulating protein homeostasis was demonstrated by the discovery that ...
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Identification of Paramyxovirus V Protein Residues Essential for STAT Protein Degradation and Promotion of Virus Replication
... V protein associates with STAT proteins in vitro via its Trp motif, whereas the down- stream Cys residues are not required for this binding ...V protein behaves similarly to that of MuV in this respect and, ...
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Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation
... modulate protein deg- ...Myc protein through the viral E3 ubiquitin ligase mLANA ...X protein also inhibits Myc protein degradation by targeting the SCF(Skp2) ubiquitin E3 ligase ...
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Genetic Dissection of Peroxisome-Associated Matrix Protein Degradation in Arabidopsis thaliana
... matrix protein deg- radation, we mutagenized a line expressing GFP – ICL, which is degraded similarly to endogenous ICL, and identi fi ed persistent GFP-ICL fl uorescence (p fl ) ...membrane protein that ...
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Molecular Pathways of Protein Degradation in Muscular Dystrophies: Targets for Therapeutic Intervention.
... of protein degradation and promote muscle regeneration would be those of choice for muscular ...attenuates protein degradation in disuse- induced muscle wasting in rats ...
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TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
... long-lived protein degradation assays, the contribu- tion of macroautophagy to the total autophagy can be approximated as the percentage of protein degradation inhibitable by lysosome ...
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A toolkit for GFP mediated tissue specific protein degradation in C elegans
... F-box protein, TIR1, that serves as a substrate recognition component for a Skp1 – Cullin – F- box (SCF) E3 ubiquitin ...elegans protein degradation ...adaptor protein ZIF-1, which targets ...
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Protein Degradation in Normal and Beige (Chediak Higashi) Mice
... liver protein were determined in normal and beige ...of protein degradation had similar effects on both normal and mutant strains and led to the conclusion that the rate of turnover of endogenous ...
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Protein degradation in Parkinson disease revisited: it’s complex
... a protein with a mitochondrial targeting sequence and a putative serine/threonine kinase domain, and PINK1 is predomi- nantly localized to mitochondria ...Parkin protein contains two RING finger motifs, has ...
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The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected Cells
... the protein expression and antiviral effect of viperin against ...viperin protein levels, as detected by immunoblotting ...for protein degradation in JEV-infected, but not in SIN-infected, ...
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PROTEIN DEGRADATION, MEIOSIS AND SPORULATION IN PROTEINASE-DEFICIENT MUTANTS OF SACCHAROMYCES CEREVISIAE
... This difference in frequency is not responsible for the deficit in protein degradation in the mutants because (1) the doubly mutant diploid prbl prcl had a high frequency of meiosis[r] ...
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β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
... Analysis of the Expression and Localization of LAMP-1 and CD63—To visualize the cellular distribution of LAMP-1 and CD63 cells by immunofluorescence microscopy, cells were fixed and permeabilized as described previously ...
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Effects of intermittent hypoxia on oxidative stress and protein degradation in molluscan mitochondria
... of protein carbonyls (but not MDA or HNE); all other experimental conditions had no effect on the levels of oxidative lesions in oyster mitochondria ...the protein carbonyls after 18 h of hypoxia ...
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Structural basis of PROTAC cooperative recognition for selective protein degradation
... We simulated the fraction of ternary complex formation for VCB, MZ1 and six individual BET BDs, using our measured binary Kds and cooperativities α Table 1 and protein concentrations of [r] ...
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Leucine Oxidation and Protein Turnover in Clofibrate induced Muscle Protein Degradation in Rats
... Treatment of hyperlipidemia with clofibrate may result in development of a muscular syndrome. Our previous investigation (1979. J. Clin. Invest.64: 405.) showed that chronic administration of clofibrate to rats causes ...
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REGULATION OF STORAGE PROTEIN DEGRADATION IN COTYLEDONS OF GERMINATING COWPEA
... Effect of different ¥lema used for extraction and assay of the enzyme (Table I) showed that both the peaks required sulfhydryl sroups for activity since exclusion of cystein[r] ...
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Review Article New insights into regulation of p53 protein degradation
... suppressor protein p53 in skin cells [37], and human colon carci- noma cells that overexpressed NQO1 accumu- late elevated level of p53 ...p53 degradation induced by overexpres- sion of ...the ...
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