protein kinase C
Protein kinase C and human uterine contractility
... Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to ...
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The Phosphoprotein of Rabies Virus Is Phosphorylated by a Unique Cellular Protein Kinase and Specific Isomers of Protein Kinase C
... cellular protein kinases that phosphorylate the P proteins of these viruses and to establish the role, if any, of this posttranslational modification in P-protein ...casein kinase II (CKII) and an ...
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Protein Kinase C-epsilon in Membrane Delivery during Phagocytosis
... that underpins pseudopod extension during Fcγ receptor (FcγR)- mediated phagocytosis. We demonstrate that the pseudosubstrate of protein kinase C-epsilon (PKC-ε) tethers PKC-ε to the Golgi by binding ...
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Ghrelin induces clock gene expression in the liver of goldfish in vitro via protein kinase C and protein kinase A pathways
... phospholipase C/protein kinase C (PLC/ PKC) and adenylate cyclase/protein kinase A (AC/PKA) intracellular signalling pathways was ...
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Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly ...and protein kinase B (Akt) in cultured human endothelial ...
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Inhibition of protein kinase C promotes dengue virus replication
... vitro kinase assay using purified recombinant DENV2 RdRp domain, containing Thr302 Ser796 and Ser885, as a ...The kinase assay showed that PKC efficiently phosphorylated RdRp in vitro ...PKC kinase ...
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Involvement of protein kinase C-epsilon in prostate malignancy
... The Protein Kinase C (PKC) superfamily continues to be a major element in prostate neoplasia as a family of targets for classes of tumour promoters and ...
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Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors
... how protein kinases are targeted to these receptors to facilitate functional modula- tion remains ...activated C kinase (RACK-1) and protein kinase C (PKC) bind to distinct sites ...
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Stimulation of porcine jejunal ion secretion in vivo by protein kinase C activators
... involve protein kinase C activation, we measured protein kinase C activity and phorbol ester binding in isolated intestinal epithelial cells and examined the effects of the ...
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Multisite phosphorylation of P-Rex1 by protein kinase C
... through protein kinase A (PKA), and such phosphorylation diminishes P-Rex1 GEF activity ...tyrosine kinase inhibitors [27], and may also regulate P-Rex1-dependent ROS production ...P-Rex1-interacting ...
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Role of Protein Kinase C Delta in Airway Mucin Secretion
... activation Protein Kinase C (PKC) specifically the delta isoform ...PKCδ kinase activity, a dominant negative PKCd construct (pEGFP- N1/PKCd K376R ) was transfected into HBE-1 ...
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Modulation of human platelet protein kinase C by endotoxic lipid A
... platelet protein of Mr 47,000, a marker of protein kinase C activation, accompanies secretion of [14C]serotonin and aggregation triggered by endotoxic lipid ...Phospholipase C ...
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The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity
... hepatitis C virus (HCV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC) ...of protein kinase C (PKC) [3, 4] and it interacts with the active site of PKC, ...
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Rx-kinase and protein kinase C in superoxide production from neutrophils
... The broad range o f biological effects of phorbol esters may be explained, at least in part, by the fact PKC comprises a multi-gene family. A further contribution could be the tissue specificity o f various PKC isotypes, ...
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
... The effects exerted by TGF signalling have long been known to be cell and context dependent (reviewed in [5, 12, 54]. In mature tissues, TGF has multiple roles that ultimately lead to homeostasis. For example, TGF ...
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Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics
... understanding the complicated roles PKCζ plays in the diverse biological processes regulating cancer. Previous studies have suggested that the activation of PKCζ is controlled by phosphoinositide 3-kinase (PI3K) ...
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Studies on a protein kinase C-phospholipase D-MAPKinase pathway
... As discussed in Chapter 1 there are now known to be five distinct classes of phorbol ester responsive proteins. To determine whether PKC was a requirement for the TPA-induced PLD activation a catalytic site inhibitor was ...
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Regulation of protein kinase C delta degration
... the kinase domain, and in doing so creates a closed conformation of the kinase (Bornancin and Parker, ...the kinase complex, however the kinase/complex has yet to be fully ...a protein ...
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Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein.
... The PKCl gene product, protein kinase C, regulates a mitogen-activated protein kinase (MAPK) cascade, which is implicated in cell wall metabolism.. Previously, we i[r] ...
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The functional diversity of Aurora kinases: a comprehensive review
... atypical Protein Kinase C; AIK: Aurora/IPL1-related kinase; ARK: Aurora-related kinase; AURK: Aurora kinase; Aur: Aurora; ARD1: Arrest Defective Protein 1; ATM: ataxia ...
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