Protein Kinase C (PKC)
Protein kinase C dependent activation of cytosolic phospholipase A2 and mitogen activated protein kinase by alpha 1 adrenergic receptors in Madin Darby canine kidney cells
... G protein-coupled receptor, the alpha 1- adrenergic receptor, promotes cellular AA release via the activation of phospholipase A2 (PLA2) in Madin-Darby canine kidney (MDCK-D1) ...the protein kinase ...
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Immunomodulatory effects of therapeutic gold compounds Gold sodium thiomalate inhibits the activity of T cell protein kinase C
... that protein kinase C (PKC) is involved in T cell activation, the capacity of gold compounds to inhibit PKC partially purified from Jurkat cells was assayed in ...inhibit PKC in ...
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Medicinal plant extracts and protein kinase C inhibitor suppress zoosporogenesis and impair motility of Phytophthora capsici zoospores
... addition, protein kinase C (PKC) inhibitors impairs zoospore motility and suppresses pathogenesis in grapevine by Plasmopara viticola (Islam et ...or PKC on zoosporogenesis, motility, ...
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Bombesin induced gastrin release from canine G cells is stimulated by Ca2+ but not by protein kinase C, and is enhanced by disruption of rho/cytoskeletal pathways
... has been investigated extensively in vivo and in vitro. G cells are stimulated by gastrin-releasing peptide (GRP)/bombesin (1–3). Sympathomimetics, acetylcholine, prostaglandin, aden- osine, and somatostatin are other ...
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Critical Role of Protein Kinase C (PKC) in the Onset of Airway Hypersensitivity in Ova Sensitized Guinea Pig Model of Asthma
... Objectives: Protein kinase C (PKC) activation plays an important role in activation of T-lym- phocytes in ...of PKC in etiopatho- genesis of airway hypersensitivity in ...Total ...
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Original Article Influence of protein kinase C ( PKC ) on the prognosis of diabetic nephropathy patients
... between protein kinase C (PKC) and the prognosis of patients with diabetic nephropathy ...of PKC was detected by immunohistochemical ...of PKC on DN ...of PKC (positive ...
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<p>Protein kinase C-iota-mediated glycolysis promotes non-small-cell lung cancer progression</p>
... whether protein kinase C-iota (PKC-iota) is associated with glucose metabolism in non-small-cell lung cancer (NSCLC) and whether its regulatory effect on metabolic and biological changes ...
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Rx-kinase and protein kinase C in superoxide production from neutrophils
... not PKC, (both kinases derived from the StM PM ...a PKC independent ...Rx- kinase activity may be the measurement of Rx stimulated superoxide ...
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Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
... a PKC inhibitor AEB071 with specificity for PKC α, β, and θ in psoriasis demon- strated not only in-vitro effects on T cell proliferation and cytokine production but also a clinical improvement in psoriatic ...
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Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway.
... (data not shown). Gel shift assays were also performed with the same extracts and an octamer binding DNA probe. No signif- icant changes were observed in the levels of octamer binding during cell stimulation or in the ...
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The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma
... [39]. PKC ε -driven cell migration was shown to be mediated, at least in part, by activating down- stream small Rho GTPases, especially RhoA and/or RhoC ...silencing PKC ε by RNAi decreased migration and ...
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Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase C epsilon
... minutes. PKC isoform activity was determined in crude whole-cell frac- tions of bronchial epithelial cells as previously described ...[18]. Kinase activity was expressed in relationship to total cellular ...
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Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma
... co-targeting PKC and the PI3K/AKT/mTOR pathway, MDM2/p53 signaling or cell cycle ...the protein MDM2 [28][29][30][31][32] and (ii) downregulation of the protein PERP in aggressive UM ...
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Conventional Protein Kinase C-α (PKC-α) and PKC-β Negatively Regulate RIG-I Antiviral Signal Transduction
... that PKC-␣ enhances IRF3-mediated gene induction upon viral infection through the activation of HDAC6 and  -catenin ...that PKC-␣/ act as negative regulators of RIG-I by phosphorylating its N-terminal ...
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MicroRNAs Mediated Regulation of Brain Derived Neurotrophic Factor Expression in Type 2 Diabetes Retinopathy
... activated protein kinases (MAPK), intercellular adhesion molecule-1 (ICAM 1), VEGF, cytokines, and decreased nitric ...of protein kinase C (PKC) may lead to increased permeability, ...
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Clinical biomarkers and molecular basis for optimized treatment of diabetic retinopathy: current status and future prospects
... Abstract: Diabetic retinopathy is a highly specific microvascular complication of diabetes and a leading cause of blindness worldwide. It is triggered by hyperglycemia which causes increased oxidative stress leading to ...
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Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null mice
... Protein kinase C (PKC) isoforms play an important role in intracellular signaling and are divided into three sub- families based on differences in the regulatory domain and the substrates ...
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Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade
... that protein kinase C (PKC) is ...activating PKC; (b) 10(-9) M ET-1 decreases Jv by PKC-, PL-, cyclooxygenase-, and lipoxygenase-dependent mechanisms; ...
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Transmissible gastroenteritis virus infection decreases arginine uptake by downregulating CAT-1 expression
... phospho-protein kinase C α (p-PKC α), phospho-epidermal growth factor receptor (p-EGFR), and enhanced the expression of caveolin-1, all of which appear to be involved in down-regulating ...
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Role of protein kinases in signal transduction and their inhibitors
... of protein kinase C (PKC) can induce cutaneous inflammation, but the precise role of each of six cutaneous PKC isoforms (alpha, delta, epsilon, eta, zeta, µ) that regulate normal skin ...
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