Protein Kinase CK2
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
... for protein kinase CK2 in the neuroinflammatory response in ...[88]. Protein kinases can be targeted by relatively small compounds that are able to pass the BBB ...of protein ...
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Protein kinase CK2 in the ER stress response
... the protein folding capacity of the ER, a reduced global pro- tein biosynthesis and elevated ER-associated protein de- ...by protein kinases, which can regulate key enzymes in these processes by ...
5
Hepatitis C Virus NS2 Protein Is Phosphorylated by the Protein Kinase CK2 and Targeted for Degradation to the Proteasome
... (NS2) protein is a hydrophobic transmembrane protein, described to be involved in different functions, such as apoptosis inhibition and gene transcription ...NS2 protein turnover and found that NS2 ...
9
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation
... Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular ...
8
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
... Protein kinase CK2 (thereafter called CK2) is a pleiotro- pic serine/threonine PK, with over 300 substrates identi- fied in mammalian cells [10] and documented roles in multiple cellular ...
16
Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives
... that CK2 is involved in the development of neurodegenerative diseases [12]: Alzheimer’s disease [13], Parkinson’s disease [14, 15], schizophrenia [16], Guam-Parkinson’s de- mentia, progressive supranuclear palsy ...
8
The Human Adenovirus Type 5 E1B 55-Kilodalton Protein Is Phosphorylated by Protein Kinase CK2
... a protein kinase CK2 phosphor- ylation consensus sequence, suggesting that this kinase is responsible for E1B-55K phosphorylation ...cellular protein kinase ...confers ...
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Antitumoral activity of allosteric inhibitors of protein kinase CK2
... cells, protein kinase CK2 is a relevant physiopathological target for development of chemical ...specific CK2 inhibitors. First, we demonstrated that CK2 inhibition (IC 50 = ...
14
Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2
... by protein kinases in eukaryotes. Expectedly, deregulation of kinase activity can contribute to aberrant signaling processes implicating kinases in the progression of diseases such as cancer ...on ...
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The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
... t Protein kinase CK2 (formerly casein kinase II), an enzyme that participates in a wide variety of cellular processes, has traditionally been classified as a stable tetrameric complex ...
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Phosphorylation of PRH/HHEX by Protein Kinase CK2 Regulates Cell Proliferation and Cell Migration in Diverse Cell Types
... odomain protein (PRH)/haematopoietically expressed homeobox protein (HHEX) is a tran- scription factor that controls cell proliferation and cell migration in a variety of tissues in the adult and in the ...
21
Mitotic Regulation of Protein Kinase CK2
... by protein kinases is a regulatory mechanism crucial for cell signalling, providing a temporary switch in protein function leading to the proper cellular response to a ...mitosis. Protein kinases ...
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Protein kinase CK2 catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma
... Protein kinase CK2 alpha (CK2α), one isoform of the catalytic subunit of serine/ threonine kinase CK2, has been indicated to participate in tumorigenesis of various ...and ...
18
Cyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase CK2 in pancreatic β cells
... taining 300 mg/l L-glutamine and supplemented with 100 units/ml penicillin and 100 µg/ml streptomycin were used for treatment of INS-1 (832/13) cells. Cells were pre-incubated in RPMI 1640 supplemented with 1 mM glucose ...
12
Protein Kinase CK2 Holoenzyme Promotes Start-Specific Transcription in Saccharomyces cerevisiae
... the CK2 holoenzyme, making the transcription complexes less active with both SBF- and MBF-dependent ...by CK2; some substrates are more phosphorylated by the holoenzyme, while others are preferentially ...
10
Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
... of CK2/CX-4945 (PDB ID: 3PE1) was chosen to prepare for the receptor and the binding site because of the low resolution of ...poses. CK2/ANP (PDB ID: 3NSZ) was then superimposed with modeled com- ...plexes. ...
9
Targeting protein kinase CK2 suppresses bladder cancer cell survival via the glucose metabolic pathway
... Protein kinase casein kinase 2 (CK2) is a conserved, ubiquitously expressed protein serine/threonine kinase that was first discovered by Burnett and Kennedy in 1954 ...[2]. ...
12
Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum
... CK2 ␣ has been shown to be essential for life for a variety of organisms (24, 31, 37). We have demonstrated here that PfCK2 ␣ is required for parasite viability. We show that para- sites lacking the enzyme are ...
10
Role of protein kinase CK2 in antitumor drug resistance
... planning CK2 targeting. First, the combination of CK2 inhibitors with other drugs might not be convenient: in melanoma and thyroid carcinoma with wt BRAF, the effect of CK2 in- hibition in ...
15
The activities of protein kinase CK2 in oogenesis of `Xenopus laevis'
... Histone deacetylase activity is accumulated in Xenopus oocytes as protein complexes and is transported to the nucleus prior to maturation.. LLINAS*, JAMES RYAN*, DARREN A.[r] ...
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