Protein Phosphatase 2A
Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A
... Previous studies have indicated that the E4orf4 protein of human adenovirus type 2 (Ad2) induces p53- independent apoptosis. We believe that this process may play a role in cell death and viral spread at the final ...
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Protein phosphatase 2A is a negative regulator of IL 2 production in patients with systemic lupus erythematosus
... message, protein, and enzymatic activity of the catalytic subunit of protein phosphatase 2A (PP2Ac), but not PP1, are increased in patients with SLE regardless of disease activity and ...
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TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae
... ABSTRACT The target of rapamycin (TOR) kinase, a central regulator of eukaryotic cell growth, exists in two essential, yet distinct, TOR kinase complexes in the budding yeast Saccharomyces cerevisiae : ...
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Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
... of protein phosphatase 2A (PP2A) have been shown previously to bind to the small t and middle T antigens (ST and MT, respectively) of ...associated protein and lipid kinase activities, ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... Calcium/calmodulin-dependent protein kinase II; cFC: contextual fear conditioning; CKO: Conditional knockout; Cont: Control; CS: Conditioned stimulus; DG: Dentate gyrus; DMSO: Dimethyl sulphoxide; ERK: ...
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Protein phosphatase 2A regulates self renewal of Drosophila neural stem cells
... Drosophila Protein phosphatase 2A (PP2A) as a brain tumor-suppressor that can inhibit self-renewal of ...Atypical protein kinase C, as well as proper mitotic spindle ...
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Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b
... X protein; Bcl-2: B-cell lymphoma 2-related protein; cDDP: cisplatin; CDK1: cyclin-dependent kinase 1; DAPI: 4, 6-diamidino-2-phe- nylindole; FCM: flow cytometry; GAPDH: glyceraldehyde-3-phosphate ...
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Protein Phosphatase 2A Enhances Activation of Human Immunodeficiency Virus Type 1 by Phorbol Myristate Acetate
... repeats. Protein phosphatase 2A (PP2A) is a phosphoprotein that plays important roles in the regulation of signal transduction and cell ...of protein phosphatase 2A (PP2Ac) ...
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B56δ related protein phosphatase 2A dysfunction identified in patients with intellectual disability
... (Ser/Thr) protein phosphatase 2A (PP2A) were identified in 16 individuals with mild to severe ID, long-lasting hypotonia, epileptic susceptibility, frontal bossing, mild hypertelorism, and ...
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Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... Given this clear clinical link, a great deal of research has focused on uncovering the molecular mechanisms that lead to LC initiation. Cancer development and progression in any cell type is often due to a com- bination ...
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Protein phosphatase 2A cooperates with the autophagy related kinase UNC 51 to regulate axon guidance in Caenorhabditis elegans
... serine/threonine protein kinase conserved from yeast to ...serine/threonine protein phosphatase 2A (PP2A-C), which plays important roles in many cellular ...
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Isolation and Characterization of par1+ and par2+: Two Schizosaccharomyces pombe Genes Encoding B′ Subunits of Protein Phosphatase 2A
... Protein phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases found in eukaryotic cells. We cloned two genes, par1 ⫹ and par2 ⫹ , encoding distinct B⬘ subunits of PP2A in fission ...
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Original Article Protein phosphatase-2A is down-regulated in patients within clear cell renal cell carcinoma
... Background: Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine ...and protein was observed in the majority of ccRCC by qRT-PCR and Western blot when compared with ...
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Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.
... 123-129 0022-538X/94/$04.00+0 Copyright ©D 1994, American Society for Microbiology Molecular Model of the A Subunit of Protein Phosphatase 2A: Interaction with Other Subunits and Tumor A[r] ...
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Adenovirus Protein E4orf4 Induces Premature APCCdc20 Activation in Saccharomyces cerevisiae by a Protein Phosphatase 2A-Dependent Mechanism
... Protein phosphatase 2A (PP2A) represents a major class of serine/threonine phosphatases that is evolutionally conserved across eukaryotes and plays a regulatory role in numerous cellular processes, ...
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Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase 1 in Tat activated HIV 1 transcription
... phosphatases, protein phosphatase 2A (PP2A) and protein phosphates-1 (PP1) were implicated in the regulation of HIV-1 ...of protein phosphatases with predomi- nant nuclear localization ...
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Genetic variation in the tau protein phosphatase 2A pathway is not associated with Alzheimer's disease risk
... Methods: In a group of 729 Spanish late-onset Alzheimer ’ s disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau ...
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Therapeutic relevance of the protein phosphatase 2A in cancer
... Continued efforts in tumor sequencing have greatly facilitated the identification of the molecular alterations that provide novel opportunities to develop customized precision medicine [1]. However, the depth of ...
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Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
... 12 0022-538X/93/127556-05$02.00/0 Copyright © 1993, American Society for Microbiology Adenovirus E4orf4 Protein Binds to Protein Phosphatase 2A, and the Complex Down Regulates ElA-Enhanc[r] ...
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Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation
... serine/threonine phosphatase 2A (PP2A) controls the phosphorylation of numerous proteins involved in cell signalling [12] and has important roles in regulating cell cycle progression, apoptosis, growth, and ...
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