Protein phosphatase 2A (PP2A)
TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae
... for protein phosphatase 2A (PP2A) in the regulation of TORC2 ...of PP2A, and deletions of components of the Far3-7-8-9-10-11 complex and PP2A rescue growth defects in lst8 D and ...
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Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... of protein phosphatase 2A (PP2A) in the pro- gression of COPD to ...induce PP2A inactivation and may result in a predisposition of COPD patients to the development of LC; and highlight ...
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Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase 1 in Tat activated HIV 1 transcription
... phosphatases, protein phosphatase 2A (PP2A) and protein phosphates-1 (PP1) were implicated in the regulation of HIV-1 ...transcription. PP2A and PP1 are a general phosphatases ...
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Therapeutic relevance of the protein phosphatase 2A in cancer
... identified protein phosphatase 2A (PP2A) as a therapeutic target in cells overexpressing the checkpoint protein MAD2 ...and PP2A, could lend to the selective killing of CIN ...
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Protein phosphatase 2A regulates self renewal of Drosophila neural stem cells
... Drosophila Protein phosphatase 2A (PP2A) as a brain tumor-suppressor that can inhibit self-renewal of ...The PP2A heterotrimeric complex, composed of the catalytic subunit (Mts), ...
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B56δ related protein phosphatase 2A dysfunction identified in patients with intellectual disability
... The clinical features of the 11 PPP2R5D cases and the 5 PPP2R1A cases are summarized in Tables 2 and 3, respectively. Despite mutations occurring in 2 different PP2A subunit genes with different biochemical ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... CaMKII. PP2A is required for the late phase of LTP [43] and modulates learning and memory via regulation of CaMKII, an important mediator of synaptic plasticity ...oscillatory protein (SCOP) and increased ...
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Genetic Analysis of B55α/Cdc55 Protein Phosphatase 2A Subunits: Association with the Adenovirus E4orf4 Protein
... E4orf4 protein and that alteration of individual residues present in these regions can limit such ...the PP2A holoenzyme containing B55 ␣ (53) ...mutant protein, as indicated, were prepared and ...
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Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Chronic Myeloid Leukaemia
... The observed reduction in CIP2A levels is very promising when considered clinically. Ponatinib is already proving effective in the combat of BCR-ABL1, T315I and other BCR-ABL1 mutants; these results would tentatively ...
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Truncated Form of the Epstein-Barr Virus Protein EBNA-LP Protects against Caspase-Dependent Apoptosis by Inhibiting Protein Phosphatase 2A
... this protein is also detectable in the cytoplasm, where it can interact with HAX-1 (6, 15, 28, 34), a protein involved in apoptosis and cell migration (36, ...7. PP2A interacts with EBNA-LP in cells ...
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FAM122A, a new endogenous inhibitor of protein phosphatase 2A
... The whole cell lysates, extracted in PBS plus 2 × SDS, were equally loaded onto SDS-PAGE and subsequently transferred to PVDF transfer membranes (Millipore Corporation Billerica, MA). After blocking in 5% non-fat milk at ...
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Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
... 2. PP2A inhibition during the final cell cycle leads to extra cell divisions during tissue ...when PP2A is inhibited during the final cell cycle to generate an increase in clones with more than 2 ...
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Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen
... targets PP2A through direct protein-protein interac- tions (39), yet little is known about the molecular basis for these ...Phospho-Akt protein levels are actually increased by knock- down of ...
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Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
... KO mice and the control were cultured, employing label-free nano-LC − MS/MS technology on a Q-exactive followed by SIEVE processing, then, the one of the most interesting protein is Y-box binding protein-1 ...
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Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation
... on PP2A activation and downregulated ERK1/2 activation leading to PC12 cell proliferation ...the PP2A activation inhibitors 1,10-phenanthroline (Phe, n = 12), okadaic acid (OKA, n = 9) and cantharidin (Can, ...
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Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development
... provides PP2A phosphatase activity. By functionally characteriz- ing the isoform PP2Ac1, we specified it as an important factor for fungal fruiting body formation, hyphal fusion, and vegetative, as well as ...
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A Novel Assay for Protein Phosphatase 2A (PP2A) Complexes In Vivo Reveals Differential Effects of Covalent Modifications on Different Saccharomyces cerevisiae PP2A Heterotrimers
... Microscopic analysis and quantification of localization. In Results, we present differences obtained by quantitating the percentage of cells with proper local- ization of GFP-PP2A subunits. Fluorescence signal in ...
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Protein Phosphatase 2A (PP2A) Regulatory Subunits ParA and PabA Orchestrate Septation and Conidiation and Are Essential for PP2A Activity in Aspergillus nidulans
... reversible protein phosphorylation is an important regulatory procedure in which protein phosphatases counteract the activities of protein ...of PP2A, resulted in a low hyphal growth rate and ...
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STAT3 Signaling in Cancer
... The negative impact of Ser727 residue phosphorylation on STAT3 activity has been proposed in several stu- dies indicating that Ser727 phosphorylation downregulates STAT3 tyrosine phosphorylation and causes altera- tions ...
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The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens.
... More recently, two cellular proteins of 36 and 63 kDa that associate with polyomavirus small and middle T antigens and with SV40 small t antigen 13, 25, 27, 31, 34-36, 41, 46 * were demo[r] ...
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