protein phosphatases
Interleukin-1β Expression after Inhibition of Protein Phosphatases in Endotoxin-Tolerant Cells
... of protein kinases in signal transduction has been well recognized, protein phosphatases have only recently emerged as important regulators of cellular function (7, ...of phosphatases in ...
7
Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus
... unfolded protein response, stressing chemicals, in addition to geldanamycin (GEL), a heat shock protein 90 (Hsp90) ...of protein phosphatases that possibly played a role in the HOG (high ...
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PROTEIN PHOSPHATASES-OCCURRENCE, CLASSIFICATION AND AS DRUG TARGETS IN HUMAN DISEASES
... . Protein phosphatase catalyzes the dephosphorylation of post translational modified serine/threonine and tyrosine residues in ...phosphoproteins. Protein kinase catalyzes the phosphorylation in which the ...
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Identification of a non purple tartrate resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?
... exception that Tyr166 (sweet potato TRAcP numbering) is replaced by His93 in Hsa_aTRACP (Figure 5). Closer inspection of the model indicates that although Tyr219, 220 and 292 are located within a putative substrate bind- ...
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The role of protein kinases and protein phosphatases in the regulation of leukaemic cell apoptosis
... The inhibition of protein phosphatases by OKA results in the hyperphosphorylation of a number of proteins, many of which are PKC targets. The results presented here indicate that activation of PKC by the ...
197
Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A.
... serine/threonine protein phosphatase ...this protein phosphatase activity has all characteristics of type 1 and 2A protein phosphatases (PP1 and ...CMV-associated phosphatases in this ...
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Synthesis of nodularin analogues as potential protein phosphatases inhibitors
... T\pe 1 protein phosphatases (PPl) comprises of widely distributed enz>TOes, found in all eukaryotic ceils. A number of different forms of PPl have been characterised.^* These forms differ in their ...
248
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases
... PP2C phosphatases? Acquisition of a new catalytic mechanism requires that the ancestral protein retain function while acquiring the changes necessary for the new catalytic ...PP2C phosphatases would ...
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Regulation of α1-adrenoceptor linked phosphoinositide breakdown in cultured glia: role of protein phosphatases
... found that the specific activity of PPl and PP2A in the particulate fraction of rat forebrain was much lower than that of the cytosol and of the particulate fractions of other tissues. That the majority of PPl and PP2A ...
236
Protein kinases and protein phosphatases in the central nervous system-Identification, characterisation and functional correlates
... acidic protein (GFAP) showed increased staining of GFAP, and changes in cell morphology from a flat to a stellate appearance with longer processes when treated with 250 nM OA (Arias et al, ...
303
Type 2C Protein Phosphatases in Fungi
... Ser/Thr protein kinase Ire1 (109), which is necessary to induce the appropriate transcriptional ...the protein kinase ...various phosphatases in re- sponse to different types of stress (95, ...
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Molecular biology of cantharidin in cancer cells
... by enhancing DNA binding activity and transactivation function of p53 on the promoters of proapoptotic genes in vivo [64]. The role of PP1 in the repair of UV-induced DNA lesions [65] and the induction of cytosine ...
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stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.
... Compari- son of nucleotide sequences reveals that bwsl+/dis2+ is highly similar to previously identified mammalian type 1 protein phosphatases (OHKURA et al. cdr muta[r] ...
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Suppression of Na+/K+ ATPase activity during estivation in the land snail Otala lactea
... the protein kinases and protein phosphatases that might act on ...these protein kinases in the natural mode of suppression of Na + /K + - ATPase activity during estivation and indicates that ...
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Recent advances in the molecular pathophysiology of atrial fibrillation
... L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases.. Ehrlich JR, et al.[r] ...
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Comparative 1D Blue Native electrophoresis analysis of Plasmodium falciparum and human proteins associated with cytoadherence
... differential protein complex ...unshaded protein name with a yellow highlighted sequence iden- tifier or a shaded protein name with a non-highlighted identifier indicates agreement between the manual ...
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Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production
... styles. Protein phosphorylation state represents the most common form of post-translational ...modification. Protein kinases and phosphatases perform a central role in the transduction of such ...
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Purification and characterisation of cell wall acid phosphatases of roots of white clover (Trifolium repens L ) : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Palmerston North, New Zealand
... With the exception of speculation that the different pI values of Apase isoforrns may simply be due to heterogeneity in oligosaccharide chains attached to the enzyme, little is known about the roles these glycan side ...
167
The Sac1 phosphoinositide phosphatases in mammals
... PIP phosphatases in the ER, rather than with menial PIP-mop-up ...PIP phosphatases may reside in the ER to regulate nuclear PIP signaling during the cell ...
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Distinct and Redundant Roles of Protein Tyrosine Phosphatases Ptp1 and Ptp2 in Governing the Differentiation and Pathogenicity of Cryptococcus neoformans
... 282-amino-acid protein, with a 46-bp 5= untranslated region (UTR) and a 48-bp 3= ...1,211-amino-acid protein, with a 46-bp 5= UTR and a 401-bp 3= UTR (GenBank accession ...fungal phosphatases and ...
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