proteinase-activated receptor-2
Proteinase-activated receptor-2: two potential inflammatory mediators of the gastrointestinal tract in Atlantic salmon
... Proteinase-activated receptor 2 (PAR-2), activated by trypsin and other serine proteinases, is a key initiator of inflammatory responses in the intestine of ...PAR 2. In ...
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Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour
... Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains ...
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Effect of Pertussis Toxin and Herbimycin A on Proteinase Activated Receptor 2 Mediated Cyclooxygenase 2 Expression in Helicobacter pylori Infected Gastric Epithelial AGS Cells
... cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed in gastric cancer, and chronic expression of cyclooxygenase-2 ...
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Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
... protein-coupled receptor proteinase- activated receptor 2 (PAR2), the latter of which functions as a cell-surface sensor for serine proteinases asscociated with the tumour ...
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Essential role for proteinase activated receptor 2 in arthritis
... in proteinase-activated receptor-2 (PAR-2) as a mediator of neurogenic inflammation (1) and nociception ...tein–coupled receptor that is rapidly desensitized fol- lowing ...
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Essential role for proteinase-activated receptor-2 in arthritis
... in proteinase-activated receptor-2 (PAR-2) as a mediator of neurogenic inflammation (1) and nociception ...tein–coupled receptor that is rapidly desensitized fol- lowing ...
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Trypsin activates pancreatic duct epithelial cell ion channels through proteinase activated receptor 2
... ly stimulate release of arachidonic acid and secretion of prostaglandins from enterocytes (9) and induce expres- sion of cyclooxygenase 2 (Bunnett, N.W., unpublished observations), which generates proinflammatory ...
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Mast cell tryptase regulates rat colonic myocytes through proteinase activated receptor 2
... Organon Teknika-Cappel (Durham, NC). Other reagents were from Sigma Chemical Co. Tissues were obtained from male Sprague-Daw- ley rats (200 g) anesthetized with 50 mg/kg i.p. sodium pentobarbital. Isolation and culture ...
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Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases
... Patient data were split to CJD (n = 36) and non-CJD (n = 23) groups (Table 1). The Wilcoxon-Mann – Whitney (WMW) nonparametric test was used for the median equity hypothesis H0 at a significance level of 0.05 for six ...
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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)
... Due to the irreversible nature of activation of PARs, for responsiveness to agonist to be retained, fresh supplies of receptor are required to be mobilized to the cell surface. Deliv- ery to the membrane requires ...
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Activation of proteinase activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
... Interestingly, co-stimulation of chondrocytes with IL-1β and PAR-2-AP showed an additional stimulatory effect, particularly on Erk1/2. A possible explanation is that Erk1/2 is not the pref- erential ...
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Anti-Inflammatory mechanisms of the proteinase-activated receptor 2-inhibiting peptide in human synovial cells
... serine protease-mediated cleavage of the N-terminus of the receptors [8,9]. Mounting evidence indicated that trypsin cleaves PAR-2 at R 34 ↓S 35 LIGKV (in human) to expose a hexameric-tethered peptide that binds ...
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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology
... an AAV2/5 control vector expressing the luciferase gene. A strong luciferase signal was observed in mice up to 28 days following DMM (see online supplementary fi gure S3) con fi rm- ing transfection longevity. Using an ...
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Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception
... also mediated PAR2-induced sensitization of ASIC3. It has been shown that heteromeric ASIC3/ASIC2b chan- nels, but not homomeric ASIC3 channels, are regulated by PKC and this regulation requires PICK1 [42]. The present ...
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The proteinase activated receptor 2 (PAR 2) mediates mitogenic responses in human vascular endothelial cells
... Endothelial cell mitogenesis assays. HUVEC were isolated from pooled primary cultures of human umbilical veins as previously de- scribed (43), and used in passages two to five. Cells were grown on gelatin-coated plates ...
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Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells
... AYPGKF-NH 2 (100 μ M, 96 h), but not to a FKGPYA-NH 2 (PAR 4 -inactive reverse sequence peptide, 100 μM), was also observed, suggesting the response to agonist peptide due to specific PAR 4 stimulation ...
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Combined upregulation of matrix metalloproteinase-1 and proteinase-activated receptor-1 predicts unfavorable prognosis in human nasopharyngeal carcinoma
... blinded to the clinicopathological parameters and clinical outcomes of the patients. The scores of the two observers were compared, and in the event of a discrepant score, the specimen was reexamined by both pathologists ...
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Proteinase-activated receptors (PARs) as targets for antiplatelet therapy
... The activation of PARs results in the stimulation of numerous intracellular signaling cascades. Classical heterotrimeric guanine nucleotide-binding protein (G protein) dependent pathways downstream of PAR activation have ...
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Regulatory network of inflammation downstream of proteinase-activated receptors
... In general, inflammation plays a role in most bladder pathologies, including bladder cancer [1-4], and repre- sents a defensive reaction to injury caused by physical damage, chemical substances, micro-organisms, or other ...
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Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact
... which receptor activation causes signalling via heterotri- meric guanyl nucleotide-binding proteins (G proteins) and downstream targets; secondly, a beta-arrestin path- way of signalling involving ligand-regulated ...
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