Proteomics and cancer detection
Quantitative proteomics in lung cancer
... lung cancer patients is highly cor- related to the stage of lung cancer; therefore, improve the diagnostic strategies for early lung cancer detection may increase patient ...quantitative ...
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A Review of the Cancer Research Proteomics Initiative
... Combinatorial proteomics applications contribute to the understanding of the functional organization of the human proteome through characterizations and measurements of protein abundance, post-translational ...
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SELDI-TOF MS Proteomics in Breast Cancer
... breast cancer proteomic profil- ...breast cancer with diverse cohort characteristics, sample collection and storage techniques, and varied analysis ...The detection of unmatched ion peaks and ...
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Bronchoalveolar lavage proteomics in patients with suspected lung cancer
... lung cancer were obtained is subsequently referred to as cases while those patients suspected of lung cancer for which cytology and histology were negative are referred as ...in detection becomes ...
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Proteomics, pathway array and signaling network-based medicine in cancer
... On the other hand, antibody detection offers great sensi- tivity and specificity to detect known proteins in a sample. However, multiplex array, i.e. protein arrays, to identify proteins with antibodies also has ...
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Mining novel biomarkers for prognosis of gastric cancer with serum proteomics
... early detection and intensive post- operative treatment for selected ...Serum proteomics conducted by SELDI-Protein- Chip platform with bioinformatics to associate complex patterns with disease has been ...
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Comparative Proteomics Analysis of Exhaled Breath Condensate in Lung Cancer Patients
... lung cancer patients as an indication of the underlying neoplastic processes, presenting a possible screening tool for the early detection of lung carcinomas ...of proteomics because of its ...
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Ovarian cancer: can proteomics give new insights for therapy and diagnosis?
... ovarian cancer represents a complex and heterogeneous disorder, it is unlikely that a single biomarker could be able to discriminate between healthy women and patients with ovarian ...early detection of ...
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Recent advances in mass spectrometry based clinical proteomics: applications to cancer research
... Abstract Cancer biomarkers have transformed current practices in the oncology ...antibody-based detection strategies, but these methods carry certain ...clinical proteomics are high- lighted with a ...
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Bioinformatics analysis of differentially expressed proteins in prostate cancer based on proteomics data
... Applying proteomics technology, Skvortsov et al 8 discovered that lamin A was statistically highly discriminatory between low and high Gleason score for PCa and might serve as a new biomarker of tumor dif- ...and ...
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Identification of potential serum biomarkers for breast cancer using a functional proteomics technology
... in proteomics has identified thousands of proteins from human serum, a high percentage of the proteins identified are enzymes with significant numbers belongs to metabolic enzymes and proteases ...breast ...
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Multivariate analysis of cancer proteomics data : towards a biological systems view and understanding
... clinical samples. This is due to normal variation between healthy individuals as well as disease heterogeneity. Another complicating factor is that the differences in protein levels between groups might be very small, ...
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Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer
... of proteomics data allowed us to assess the value of complementary data provided by this approach in the context of the molecular diagnostic evaluation of mCRC ...atypical proteomics profile which ...
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The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine
... MS-based proteomics into the clinic is the associated cost and the cutting-edge expertise that is still ...of cancer tissues has become quite robust, being performed in an automated manner on a robotic ...
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Proteomics analysis of colon cancer progression
... quantitative proteomics analysis of individual small colon cancer biopsies (averag- ing 5 mm 3 ) and gain an understanding of anatomically- specific disease ...of cancer progression and represent ...
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Genomics and proteomics approaches to the study of cancer-stroma interactions
... The product of ARID4A - AT rich interactive domain 4A (RBP1-like) - also known as RBP1 or RBBP1 gene, interacts with the tumor suppressor retinoblastoma (pRB) and histone-modifying complexes, repressing pro- moters of ...
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Proteomics goes forensic: detection and mapping of blood signatures in fingermarks
... fragmentation enabling partial protein identification. However, instrumental capability for this type of analysis is not widespread; furthermore the sheer number of protein present in blood, the differential protein ...
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Functional proteomics outlines the complexity of breast cancer molecular subtypes
... Our study has some limitations. The discovery series was limited to patients with node-positive disease, who have a poorer outcome than their node-negative counterparts. However, the meta-validation series is more heter- ...
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Comparative proteomics analysis of oral cancer cell lines: identification of cancer associated proteins
... patients. Cancer- ous tissues were derived from surgically resected tissue specimens from three different oral squamous cell carcin- oma ...oral cancer cell lines and primary cultures were derived from ...
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Comparative proteomics analysis of oral cancer cell lines: identification of cancer associated proteins
... All experiments were performed according to manufac- turers’ instructions. Total mRNA was extracted from cell pellets using RNAqueous®-4PCR Kit (Ambion). High Cap- acity cDNA Reverse Transcription kit (Applied ...
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