pulmonary fibrosis
Idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known ...dense fibrosis, ...
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WNT1 inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of respiratory ...of fibrosis are poorly ...nary fibrosis, increased proliferation and altered ...
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TNF Gene Polymorphism in Idiopathic Pulmonary Fibrosis
... 13. Pantelidis P, Fanning GC, Wells AU, Welsh KI, Du Bois RM. Analysis of tumor necrosis factor-alpha, lymphotoxin- alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic ...
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Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis
... in pulmonary fibrosis is only emerging, Saito et ...lung fibrosis, DHA may be mitigating the development of fibrosis by inhibiting bleomycin induced IL-6 ...
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Previous Pulmonary Fibrosis in Dermatomyositis/Polymyositis: A Predictive Factor for Pulmonary and Extra Pulmonary Tuberculosis
... previous pulmonary fibrosis in dermatomyositis/polymyositis was more prevalent in the Tuberculosis+ group ...model, pulmonary fibrosis was sig- nificantly associated with Tuberculosis (Odds ...
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Idiopathic pulmonary fibrosis: pathogenesis and management
... induces pulmonary fibrosis through both the abnormal secretory pattern of the lung epithelium and the increased resistance to apoptosis of myofibroblasts ...
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The therapy of idiopathic pulmonary fibrosis: what is next?
... severe fibrosis and is associated with diminished survival in IPF patients [84, ...either pulmonary hypertension–IPF or IPF have yielded negative results ...Idiopathic Pulmonary Fibrosis) ...
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Pirfenidone treatment of idiopathic pulmonary fibrosis
... Pirfenidone is an intriguing new drug for the treatment of IPF, with approval in Japan and further sales in India. A wide variety of effects on cells has made understanding the mode of action difficult, and further ...
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Role of pirfenidone in the management of pulmonary fibrosis
... progressive fibrosis, there has been little clinical research to establish a potential role for antifibrotic agents in non-IPF ...of pulmonary fibrosis, and pirfenidone is reasonably well tolerated ...
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The role of CXC chemokines in pulmonary fibrosis
... The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization ...
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Lymphatics in lymphangioleiomyomatosis and idiopathic pulmonary fibrosis
... FIGURE 3. Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red) antibodies. Lymphatic vessels (D2-40+; black ...
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Fibrocytes in pulmonary fibrosis: a brief synopsis
... body. Fibrosis is defined by the overgrowth, hardening and/or scarring of tissues and is attributed to excess deposition of extracellular matrix (ECM), including collagens, proteoglycans and glycoproteins ...in ...
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Coagulation and anticoagulation in idiopathic pulmonary fibrosis
... of pulmonary fibrosis, the degree of PAI-1 gene expression positively correlated with lung collagen deposition, supporting a relationship between PAI and fibrosis ...
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Physiology of the lung in idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and one of the most frequently diagnosed interstitial lung diseases ...
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The role of infection in the pathogenesis of idiopathic pulmonary fibrosis
... the pulmonary fibrosis associated with the rare genetic disorder Humansky– Pudlak syndrome [30, ...MHV-68-induced pulmonary fibrosis in aged mice is associated with up-regulation of the potent ...
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Hsp90 regulation of fibroblast activation in pulmonary fibrosis
... Inhibition of Hsp90 attenuates fibroblast migration and invasiveness. Excessive migration and invasiveness are hallmarks of fibroblast activation that contribute to severe fibrotic lung disease (6, 7, 41). To iden- tify ...
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Idiopathic pulmonary fibrosis: the need for early diagnosis
... Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease, of a progressive nature, unknown etiology, limited to the lung, which, in the context of the idiopathic interstitial pneumonias ...
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Towards a better diagnosis of idiopathic pulmonary fibrosis
... ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias, and poses significant clinical challenges. IPF diagnosis is based on clear-cut computed tomography ...
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Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis
... FIGURE 7. Current therapeutic approaches targeting profibrotic signalling pathways. Those pathways potentially leading to fibrosis have been used to develop targeted therapies for idiopathic pulmonary ...
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Managing diagnostic procedures in idiopathic pulmonary fibrosis
... However, there are significant limitations concerning the four minor criteria of these diagnostic guidelines. For example, the specification of patient age of o50 years excludes a small but key patient group in which an ...
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