Pump inhibitor
Micronutrient Consequences of Long Term Proton Pump Inhibitor Therapy
... PPIs have been a remarkable success story. Omeprazole was the first proton-pump inhibitor to be introduced in Europe in 1988. It was quickly shown to be superior to all previously available anti-secretory ...
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Chronic use of proton pump inhibitor: A Narrative Review
... Because gastric acidity plays the role of protective barrier against infections of the upper gastrointestinal tract, hypochlorite has been associated with increased intestinal infections and respiratory infections caused ...
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Formulation and optimization of oro dispersible tablet of rabeprazole sodium as proton pump inhibitor
... Rabeprazolea proton pump inhibitor the most effective pharmacotherapy for treating acidity related disorders. The main objective of the study is to formulate and optimize an orodispersible tablet of ...
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Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions
... Abstract: A significant percentage of patients with gastroesophageal reflux disease (GERD) will not respond to proton pump inhibitor (PPI) therapy. The causes of PPI-refractory GERD are numerous and ...
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Formulation development of enteric coated tablets of a proton pump inhibitor for stability enhancement
... In the present investigation enteric coated formulation of proton pump inhibitor which is a substituted benzimidazole derivative was developed to enhance its stability. The tablets were coated with HPMC ...
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Formulation and Optimization of Oro dispersible Tablet of Pentoprazole Sodium as Proton Pump Inhibitor
... proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric ...
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Evaluation of costs accrued through inadvertent continuation of hospital-initiated proton pump inhibitor therapy for stress ulcer prophylaxis beyond hospital discharge: a retrospective chart review
... Proton pump inhibitor (PPI)-based stress ulcer prophylaxis (SUP) has been widely prescribed in noncritically ill patients who are at low risk for clinically significant bleeding, which is then injudiciously ...
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Efficacy of "HLE"—a multidrug efflux-pump inhibitor—as a disinfectant against surface bacteria
... 2.7. Effect of sub-inhibitory HLE concentrations on efflux-pump gene expression Six bacterial strains (1%) were each dosed (or not, as a control) with ½-level of MIC of HLE in TSB broth (2 ml) and then incubated ...
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Proton pump inhibitor omeprazole attenuates hyperoxia induced lung injury
... Fifteen does 96 pups were used for the assessment of lung function and histology morphometry and immunohistochemistry at day 5 of life Omeprazole was administered prenatally to the doe 2[r] ...
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CYP2C19 Phenotype and Risk of Proton Pump Inhibitor–Associated Infections
... WHAT THIS STUDY ADDS: In a retrospective cohort of 670 children treated with proton pump inhibitors, children with normal CYP2C19 function had more infection events than did children wit[r] ...
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Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed
... proton pump inhibitors (PPI), renders tumor cells more sensitive to a variety of anticancer drugs [3] have suggested that the administra- tion of PPI as chemosensitizers might be an ...
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STABILITY ENHANCEMENT OF PROTON PUMP INHIBITOR IN STOMACH: FORMULATION AND IN VITRO EVALUATION OF STABILIZED PROTON PUMP INHIBITOR
... Formulation of the tablet using pantoprazole rosin complex Pantoprazole sodium tablet was prepared using 10 station automatic tablet compression machine (Rimek Mini Press 1). The excipients were selected based on direct ...
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Esophageal Strictures during Treatment with a Proton Pump Inhibitor
... Background: The development of esophageal stricture during treatment with high dose chemo- therapeutic agents is well known and documented in the literature. With the introduction of pro- ton pumps inhibitors (PPI), the ...
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A Review on Proton Pump Inhibitor for The Treatment of Peptic Ulcer
... proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal ...
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Acid suppressive agents and risk of Mycobacterium Tuberculosis: case–control study
... Keyword: Proton pump inhibitor, Histamine2-receptor antagonist, Mycobacterium Tuberculosis , National health insurance database, Taiwan.. Background.[r] ...
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Detection and Prevalence of Active Drug Efflux Mechanism in Various Multidrug Resistant Klebsiella pneumoniae Strains from Turkey
... Antibiotic susceptibility testing and ESBL detection. MIC determinations for four structurally unrelated classes of bacterial drugs were carried out using a twofold broth dilution method in MH broth according to the ...
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Effects of Nicotinic and Muscarinic Agents on an Identified Motoneurone and its Direct Afferent Inputs in Larval Manduca Sexta
... In contrast to the effects of NMN, it was observed that the acidic pump inhibitor, hippuric acid Nijhout, 1975, had no effect on the threshold for nicotine-induced depolarization or on t[r] ...
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High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors
... Proton pump inhibitors have been shown to be highly effective in inhibiting V-ATPases in vitro and well tolerated and effective in murine models, improving response to chemotherapy and tumor control ...proton ...
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CAPSULE IN CAPSULE DOSAGE FORM WITH MINI TABLETS FOR THE TREATMENT OF HELICOBACTER PYLORI
... The current investigation involves proton pump inhibitor based therapy (Lansoprazole + Clarithromycin + Amoxicillin) combining three drugs with Capsule in capsule technology for the tre[r] ...
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... proton pump inhibitor of same drug was continued twice daily for a total of 2 weeks followed by once daily for next 2 weeks to ensure complete ulcer ...
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