Purified protein derivative
Effects of Serial Skin Testing with Purified Protein Derivative on the Level and Quality of Antibodies to Complex and Defined Antigens in Mycobacterium bovis-Infected Cattle
... Several serological tests designed to detect antibodies to immunodominant Mycobacterium bovis antigens have recently emerged as ancillary tests for the detection of bovine tuberculosis in cattle, particularly when used ...
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Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis
... carrier protein; Apa: Alanine and proline rich protein; BCG: Bacillus Calmette-Guerin; BfrA: Bacterioferritin; BLAST: Basic Local Alignment Search Tool; CFP10: Culture filtrate antigen EsxB; EF-Tu: ...
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Managing Recalcitrant Warts: Facts about Bacillus Calmette Guerin (BCG), Mycobacterium Indicus Pranii (Mw Vaccine), and Purified Protein Derivative (PPD) as Immunotherapy
... a purified protein derivative (PPD) of mycobacterium antigens which elicit immune response in the classic example of delayed hyper- sensitivity ...
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Serum Antibody Responses to 10 Mycobacterium tuberculosis Proteins, Purified Protein Derivative, and Old Tuberculin in Natural and Experimental Tuberculosis in Rhesus Monkeys
... and purified protein derivative (PPD) are widely used for tuberculin skin testing (TST) in diagnosis of tuberculosis (TB) but often yield poor specificity and anergy in ...10 purified ...
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Purified protein derivative of Mycobacterium tuberculosis and excretory secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
... Abstract A large series of T cell clones TCC specific for purified protein derivative PPD of Mycobacterium tuberculosis total 60 or Toxocara canis excretory/secretory TES antigen total 6[r] ...
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Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals
... Study design and setting: Prospective meta-analysis of randomized clinical trials (RCTs) that evaluated the effectiveness of isoniazid chemoprophylaxis versus placebo for preventing the incidence of tuberculosis disease ...
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Long-Incubation-Time Gamma Interferon Release Assays in Response to Purified Protein Derivative, ESAT-6, and/or CFP-10 for the Diagnosis of Mycobacterium tuberculosis Infection in Children
... Long-incubation-time purified protein derivative (PPD), ESAT-6, and CFP-10 IGRA were performed and evaluated for their accuracy in correctly classifying the ...
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Evaluation of the Safety and Immunogenicity of Two Antigen Concentrations of the Mtb72F/AS02A Candidate Tuberculosis Vaccine in Purified Protein Derivative-Negative Adults
... chlorophyll protein (PerCP)-conjugated anti-CD4 and allophycocyanin (APC) H7-conjugated anti- CD8 antibodies (BD Biosciences) and were fixed with a Cytofix/Cytoperm buffer kit ...
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Tuberculous anergic sera or purified protein derivative treatment induces modification in lymphocyte transformation of cells from patients with tuberculosis
... Regarding the role of antibodies in the tuberculous process, we believe that specific antibodies are the most probable serum factor which interferes with the ability of reactive cells to[r] ...
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The ID93 Tuberculosis Vaccine Candidate Does Not Induce Sensitivity to Purified Protein Derivative
... T uberculosis (TB) remains a huge global health problem, with nearly 1.3 million deaths and more than 8.5 million people developing TB in 2012 due, in part, to the lack of an effective vaccine for the prevention of ...
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Production and proteomic characterisation of purified protein derivative from Mycobacterium avium subsp. paratuberculosis
... genetic strain differences affecting proteomic composi- tion of PPDj. Multiple reaction monitoring (MRM) ana- lysis was used to qualify the relative abundance of FadE3_2 across different PPDj and PPDa samples. Based on a ...
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A novel mutation in NCF2 resulting in very-early-onset colitis and juvenile idiopathic arthritis in a patient with chronic granulomatous disease
... Furthermore, microbiological testing for infectious diarrhea, including stool culture and sensitivity tests, a stool ova and parasite examination, Clostridium difficile toxin test, and Giardia lamblia and Cryptosporidium ...
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Cytokine Responses to Stimulation of Whole Blood from Patients with Buruli Ulcer Disease in Ghana
... tuberculin purified protein derivative (PPD) of whole blood from 39 (23 early- and 16 late-stage) BUD patients and 39 healthy control subjects in ...
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The Study of Th1/Th2 Cytokine Profiles (IL-10,IL-12,IL-4,and IFN) in PBMCs of Patients with Multidrug Resistant Tuberculosis and Newly Diagnosed Drug Responsive Cases
... Materials and Methods : This study investigated the profiles of IFN-γ, IL-12, IL-10, and IL-4 in response to a purified protein derivative (PPD) in peripheral blood mononuclear cells (P[r] ...
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ESAT 6/CFP 10 Fusion Protein and Peptides for Optimal Diagnosis of Mycobacterium tuberculosis Infection by Ex Vivo Enzyme Linked Immunospot Assay in The Gambia
... There is an urgent need for reproducible and rigorous frameworks to assess new tests for the diagnosis of Mycobac- terium tuberculosis infection (13). We have recently presented a reproducible model which uses an ...
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Proteomic analysis of protein purified derivative of Mycobacterium bovis
... The diagnostic test for the control and surveillance of bTB used worldwide is the Tuberculin Skin Test (TST), which is based on in vivo intradermal inoculation of purified protein derivative from M. ...
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CD69 Expression on CD4+ T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization against Mycobacterium tuberculosis Antigens
... with purified protein derivative (2 tuberculin units) was used to evaluate the tuberculin reactivities of 52 individuals from four experimental groups: Mycobacterium bovis BCG-vaccinated healthy ...
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Mediation of Host Immune Responses after Immunization of Neonatal Calves with a Heat-Killed Mycobacterium avium subsp. paratuberculosis Vaccine
... Vaccination with Mycopar resulted in highly significant (P ⬍ 0.01) upregulation of IFN- ␥ production by PBMCs in response to either of the M. avium subsp. paratuberculosis antigen prep- arations (JPPD or MPS) beginning ...
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Inhibition of anti tuberculosis T lymphocyte function with tumour necrosis factor antagonists
... to purified protein derivative (PPD) (a) and to culture filtrate protein (CFP)-10 (b) was analysed using the thymidine incorporation, (PKH)-26 dilution, and enzyme- linked immunosorbent spot ...
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Human macrophage activation Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasone
... Addition of specific antigen, purified protein derivative, or T cell mitogens to mononuclear cells prevented the appearance of macrophage mannosyl receptor activity and lymphokine, gamma[r] ...
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