purinergic signaling
Purinergic Signaling in Neutrophils During Inflammatory Diseases
... Purinergic signaling is a heterocyclic aromatic molecule, which is one of the oldest and most influential biochemical compounds in the history of evolution(1, ...8). Purinergic signaling ...
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Putative roles of purinergic signaling in human immunodeficiency virus-1 infection
... of purinergic signaling mechanisms as key regulators of many aspects of immune ...contents, purinergic recep- tors allow immune cells to recognize the ATP that is re- leased into the extracellular ...
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Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways
... of signaling molecules have been attributed to dying neurons, including (but not limited to) cytokines, react- ive oxygen species, damage-associated molecular pat- terns (DAMPs), excessive neurotransmitters, and ...
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Induction of antiinflammatory purinergic signaling in activated human iNKT cells
... Purinergic suppression of iNKT cell activation appears to be important in disease processes inasmuch as iNKT cells have been implicated as mediators of adverse responses to ischemia-reperfusion/transplant injury ...
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Some aspects of purinergic signaling in the ventricular system of porcine brain
... Purines such as adenine and guanine beside com- mitted in neurotransmition and neuromodulation also function as trophic factors [17-19]. Ectopurines are involved in the activation of differentiation and neurito- genesis ...
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Genomic Organization of Purinergic P2X Receptors
... The evolutionary origin of P2X receptors is still unclear; however, ancestral organisms diverging as far as 1 bil- lion years ago have a single P2X receptor that has pharmacological and biophysical properties that ...
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Central Glutamatergic Purinergic System Importance in Brain/Neural Plasticity
... Extracellular nucleotides influence a wide variety (previously described) of short-term (acute) physiological processes, including endocrine and exocrine release, immune reactions, inflammation, nociceptive ...
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Resetting intrinsic purinergic modulation of neural activity: an associative mechanism?
... The associative mechanism proposed here has the distinction that it can operate over much longer time scales than those associated with mechanisms based on NMDA receptor- dependent long-term potentiation (typically, ⬃100 ...
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Purinergic dysregulation causes hypertensive glaucoma–like optic neuropathy
... Nucleotides have been reported to be present in the aqueous humor (33) and released from various eye tissues and cells (9, 34–37) in response to physiological stimuli; for example, physiological IOP elevation evokes ...
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Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration
... autocrine signaling through purinergic receptors contribute to T cell activation at the immune synapse that T cells form with ...and purinergic signaling for their migration to ...feed-forward ...
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ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells
... by purinergic signaling cascades, and these may provide important drug targets for bladder disorders such as interstitial cystitis, urge incontinence, outlet obstruction, and female idiopathic detrusor ...
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purinergic receptor regulates steroid synthesis and proliferation of ovarian luteal cells
... 6 purinergic signaling regulated progesterone secretion by inhibiting the expression of CYP11A, 3β-HSD and StAR in luteal ...MAPK signaling and downstream SF1 may contribute to the ...
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Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease
... calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and ...
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Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function
... upregulated purinergic signaling is commonly ...this purinergic pathway will be of particular relevance in treating bladder ...on purinergic contractility and has little or no effect on ...
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Purinergic signalling in bone
... Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could raise intracellular calcium and induce secondary messenger activation – events crucial to ...
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
... [11,12]. Purinergic signaling is also believed to play an important role in the development and proliferation of glial cells under both physiological and pathological conditions, including those associated ...
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Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells
... and purinergic signalling appear to have similar paracrine effects on ion and fluid transport in exocrine pancreas, we hypothesized whether there was any interaction between these two intra-ductal regulatory ...
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Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
... The importance of establishing cellular replacement therapies is increasing nowadays. These therapies are based on stem cells due to their capability of originating other cell types by differentiation, or even releasing ...
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Combined electrophysiological and biosensor approaches to study purinergic regulation of epileptiform activity in cortical tissue
... In contrast, the increase in current that is measured when a biosensor is inserted into tissue cannot be used to measure the extracellular tone of an analyte, as clearly cells will be da[r] ...
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Purinergic P2Y14 receptor modulates stress induced hematopoietic stem/progenitor cell senescence
... The role of P2 receptors as regulators of hematopoiesis has been documented (9, 10), but the underlying mechanisms by which purinergic receptors exert their effects in hematopoietic cells have not been studied in ...
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