Purkinje cell
Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia
... controlling Purkinje cell fusion in response to injury; however, inflammatory cues are known to play a physiologically significant ...between Purkinje cells and BMDCs occurs ordinarily at low levels, ...
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Estimation of Purkinje cell quantification and volumetry in the cerebellum using a stereological technique
... with Purkinje cells serving as the only output from the ...the Purkinje cells, responsible for motor coordination and control of the motor functions in ...of Purkinje cells and their volumes may be ...
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PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
... Cardiac Purkinje cells are important triggers of ventricular arrhythmias associated with heritable and acquired syndromes; however, the mechanisms responsible for this proarrhythmic behavior are incompletely ...of ...
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A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization
... Probing of a commercial protein microarray containing >9000 human full-length proteins revealed strong bind- ing of the patient ’ s serum to Rho GTPase activating pro- tein 26 (ARHGAP26; alternative designations ...
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Spatiotemporal Analysis of Purkinje Cell Degeneration Relative to Parasagittal Expression Domains in a Model of Neonatal Viral Infection
... life. Purkinje cell (PC) damage has been reported for several models of early-life viral infection, including NBD; however, the time course and distribution of PC pathology have not been investigated ...
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse
... the Purkinje cell layer, in the region in which Lugaro cell somata and dendrites lie and their axons would be expected to run, also strengthens this ...
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EFFECT OF EARLY NEONATAL EXPOSURE TO DELTAMETHRIN ON THE PURKINJE CELL NUMBER IN RAT CEREBELLUM
... of Purkinje cells is very limited, although reasonable amounts of data exist for the adult ...the Purkinje cells in the adult rats ...in Purkinje cells after exposure to 7 mg/kg of oral deltamethrin ...
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Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites
... cerebellar Purkinje neurons in male Sprague-Dawley rats and analyzed the relationship between spontaneous EPSCs on both ...in Purkinje cell ...in Purkinje cells the excitability along the ...
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AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
... in Purkinje cells (PCs) to shed light on the pathogenic cascade in the neurons mainly affected in the human ...a cell-autonomous requirement of AFG3L2 for survival of ...
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Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα
... the Purkinje cells (PCs), which display a striking reduction in the growth and branching of their dendritic arborization [6]) and delays synaptic formation between PCs and granule cells [3-5,7] (for review, see ...
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Neurogenin 2 regulates progenitor cell cycle progression and Purkinje cell dendritogenesis in cerebellar development
... Tissues were prepared as described (Croci et al., 2006). Mouse primary antibodies: calbindin, parvalbumin (1:1500; Swant, Bellinzona, Switzerland); SMI32 (1:250; Sternberger Monoclonals, Lutherville, MD, USA); NeuN ...
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Functional aspects of a mutation in the α2δ-2 calcium channel subunit of the ducky mouse, a model for absence epilepsy and cerebellar ataxia
... in Purkinje cell development is less well understood, but considering that the formation of radial Bergmann fibres in the cerebellar cortex precedes dendritogenesis, it is conceivable that they provide both ...
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Journal of Applied Pharmaceutical Science
... the Purkinje cell layer and the granular ...of Purkinje cells, in addition to two types of inhibitory interneuron, stellate and basket cells (Llinas et ...onto Purkinje cell ...the ...
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Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse
... visualize Purkinje cell soma, axons, and dendrites at a 1:10,000 ...differentiated Purkinje cells with carbonic anhydrase 8 (CAR8) from other cells that lacked this metalloenzyme at a 1:500 ...
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Mathematical model of bursting in dissociated Purkinje neurons
... full Purkinje cell morphology, its inherent trimodal (or tonic) firing pattern can be eventually replaced with a phase of bursting and then a depolarisation block ...isolated Purkinje somata ...
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Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1
... (1:100, Cell Signaling 2177) and anti-human specific nuclei antigen (1:100, Millipore MAB1281) immunohisto- chemical ...of Purkinje cells in the cerebellum also declined in these two ...of Purkinje ...
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Firing Patterns of Cerebellar Purkinje Cells During Locomotion and Sleep
... step-averaged Purkinje cell firing rates tend to be higher at faster speeds (Arm- strong and Edgley, ...the Purkinje cell population is not uniform, but highly heterogeneous, and exhibits ...
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Sørensen, Jonna (2007): Untersuchungen zur Funktion von Thioredoxin Reduktase 1 in der ZNS-Entwicklung in konditionalen Knockout-Mäusen. Dissertation, LMU München: Tierärztliche Fakultät
... molecular-, Purkinje-cell- and granular layer seen in the posterior part of the cerebellum is not persistent towards the anterior part due to lack of differentiation of the molecular and granular ...
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From mice to men: lessons from mutant ataxic mice
... of Purkinje cells, abnormal Purkinje cell dendritic trees, Bergmann glia proliferation, shrinkage and gliosis of the molecular layer and the presence of ectopic Purkinje cells in the molecular ...
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Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model
... that Purkinje cells pro- vide the sole output of the cerebellar cortex and that these cells express high levels of UBE3A, it is also not surprising that deficient Purkinje cell function is generally ...
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