Pyridine-Derivatives
L Proline as an Efficient Organocatalyst for Synthesis of Pyridine Derivatives
... of pyridine derivatives serve as high-potency agonists for the human adenosine receptors and act as potential therapeutic agents for the treatment of Parkinson’s disease and Prion disease ...Besides, ...
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Synthesis of Pyridine Derivatives in Multicomponent Cascade Coupling Strategy using Green Solvent
... diphenylnicotinonitrile derivatives following multicomponent reaction pathway by using an efficient and recyclable Polyethylene glycol as a ...protocol, pyridine derivatives were synthesized by using ...
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MICROWAVE ASSISTED SYNTHESIS OF IMIDAZO[1,2 a]PYRIDINE DERIVATIVES AND THEIR ANTI INFLAMMATORY ACTIVITY
... Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic ...[1,2-a] pyridine-3-yl) acetamido) methyl) benzamide and N- (4-methoxybenzyl)-4- ...
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EVALUATION OF ANTIPROLIFERATIVE POTENCY AND INDUCED BIOCHEMICAL PARAMETERS OF NOVEL PYRIDINE DERIVATIVES AGAINST LEUKEMIA, LUNG, BREAST AND COLON CANCER CELL LINES
... selected Pyridine derivatives on some enzymes such as aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP), in addition to albumin, globulins, creatinine, total lipids, ...
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Synthesis, Characterization and Molecular Docking of Novel Quinoline and Pyridine Derivatives
... and pyridine derivatives 6a-h are synthesized by the coupling of hydrazide derivatives 4a-b with substituted carboxylic acids 5a-c in the presence of N,N,N’,N’-tetramethyl-o-(benzotriazol-1-yl) ...
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Synthesis, Characterization and Evaluation of Biological Activity of Pyridine Derivatives
... 8. Lopez-Martinez, M, Salgado-Zamora, H, San-Juan, E. R, Zamudio, S, Picazo, O, Campos, M. E, Naranjo-Rodriguez, E. B. “Anti-anxiety and sedative profile evaluation of imidazo [1,2-a]pyridine derivatives”. ...
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Synthesis of pyrano[2,3 d]pyridine, pyrazolo[3,4 b]pyridine derivatives by microwave irradiation and study of their insecticidal activity
... 5-Amino pyrazole 4[1] was transformed to pyrazolo pyridine derivatives 7 by microwave irradiation with diethyl malonate. Alternatively it was synthesized by two step process through open chain derivative 6 ...
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DESIGN AND SYNTHESIS OF NOVEL IMIDAZO[1,2 A]PYRIDINE DERIVATIVES AND THEIR ANTI BACTERIAL ACTIVITY
... infrared, mass spectral analysis, and screened for their antibacterial activity by disc diffusion method. Molecular docking studies were performed with a bacterial beta subunit of DNA gyrase using Auto Dock 4.2.6, and ...
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New potential antitumoral fluorescent tetracyclic thieno[3,2 b]pyridine derivatives: interaction with DNA and nanosized liposomes
... The interaction with DNA of two new potential antitu- moral fluorescent planar thieno[3,2- b ]pyridine deriva- tives was studied using spectroscopic methods. Compound 2 was shown to be the most intercalative ...
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Synthesis and biological evaluation of some new cyano pyridine derivatives
... cyanopyridine derivatives which proved to be active against the herpes virus and the human immunodeficiency virus ...Cyanopyridine derivatives found to possess a wide range of biological activity such as ...
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Synthesis and antimicrobial activity of some new Imidazo[1,2 a]pyridine derivatives
... Imidazo[1,2-a]pyridine has significant importance in the pharmaceutical industry owing to the interesting biological activities displayed over a broad range of therapeutic classes, exhibiting like ...
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SYNTHESIS OF NEW BIS IMIDAZOLYLPYRIDINES AS ANTCANCER AGENTS
... A convenient one-pot, three-component synthesis of 2,6-bis (imidazol-5-yl)-4-aryl pyridine derivatives (3a–l) by Chichibabin reaction has been reported. These compounds were synthesized by the reaction of ...
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Facile synthesis and antiproliferative activity of new 3-cyanopyridines
... The results of the present study indicate that the cyanoacid hydrazones and sodium 3-oxo-3-heterylprop- 1-en-1-olates or sodium (2-oxocycloalkylidene)metha- nolates are useful precursors for the synthesis of various ...
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Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group
... Results: The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-dioxoisoindolin-2-yl)phenyl)ethylidene)hydrazine- carbothioamidein ethanol and triethylamine yielded ...
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The Uses of Cyclopentanone for the Synthesis of Biologically Active Pyran, Pyridine and Thiophene Derivatives
... the pyridine derivatives 6a-c the 4-methyl substituent 6c showed the higher potency than 6a and ...thiophene derivatives 7a-c, it is clear that compounds 7b and 7c are more potent than ...pyrimidine ...
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SYNTHESIS, ANTIMICROBIAL ACTIVITIES OF SOME NOVEL PYRIDINE AND PYRIMIDINE DERIVATIVES
... 9. Bernardino AM, Ferreira VF, Fontoura GAT, Frugulhetti ICPP, Lee MY, Romeiro GA, Souza MCBV, Sa P. Synthesis of 4-anilino-1H-pyrazolo[3,4-b]pyridine derivatives and their in vitro antiviral activities. ...
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Synthesis, molecular docking and ADME prediction of some pyridine and pyrimidine derivatives as anti colorectal cancer drugs
... [5-7] derivatives were associated with broad spectrum of biological activities including antituberculosis [8,9], anticonvulsant, anti-inflammatory [10], insecticidal [11,12], antifungal [13] and antitumor ...two ...
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SYNTHESIS OF NOVEL IMIDAZO [1, 2 a] PYRIDINE FOR THEIR POTENT ANTI CONVULSANT ACTIVITY
... Determination of Anti-Convulsant Activity: An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (MES) induce methods. The Maximal ...
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Cu (MeCN) 4BF4 Catalyzed Addition of 2-Pyridylzinc Bromide to Acid Chlorides
... nucleophilic addition of 2-pyridinezinc bromide to acid chloride is an important reaction constitute a C-C bond formation and ketone functional group synthesis. The 2- benzoyl pyridine derivatives has ...
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PGR Evaluation of Novel Synthesized Five and Six Membered Cyclic Imides
... 3) 1-(6-methylpyridin-2-yl) pyrrolidine-2,5-dione (iii): Whitish Solid, C10H10 O2N2, MW: 190.20, Product %: Conventional: 66.37% Green: 70.67%, MP: 148-50 ºC, Cal: C (63.15) H (5.30) N (14.73); Obs: C (63.32) H (5.51) N ...
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