Pyrimethamine-resistant P. falciparum
Effect of Plasmodium falciparum sulfadoxine pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta analysis
... and P falciparum infection with increasing prevalence of molecular sulfadoxine-pyrimethamine resistance ...highly resistant sextuple-mutant parasites (harbouring the quintuple mutant haplotype ...
11
The usefulness of twenty four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine pyrimethamine against falciparum malaria in Papua New Guinea
... CQ resistant genetic background in the parasites as reported previously ...the pyrimethamine related gene loci pfd- hfr S108N and ...analysed P. falciparum isolates from patients attending ...
10
Prevalence of molecular markers of sulfadoxine–pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan
... Artemisinin resistance has been detected along the Thailand-Cambodia border, in Vietnam, Myanmar, and other countries in Southeast Asia [23]. Delayed parasite clearance was first observed in P. ...
9
Drug resistance to sulphadoxine pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania
... of resistant parasite strains against the drug ...among P. falciparum isolates from children of Mlimba division of Kilomero district of ...cated falciparum malaria [18,19], the anticipation ...
11
<p>Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) Among <em>Plasmodium falciparum</em> Isolates on Bioko Island, Equatorial Guinea: 2011–2017</p>
... the resistant genotypes, while recombination and mutation would begin to increase heterozygosity in markers fl ank- ing the resistance-conferring genes, degrading the selec- tive ...of resistant haplotypes ...
10
Identification of pyrimethamine and chloroquine resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples
... The identification of pfcrt and dhfr as target genes for drug resistance provides solid ground for exploring the geographical distribution and spread of CQ- and Pyr- resistant P. falciparum. However, ...
8
Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine pyrimethamine as first line treatment in 2002, in southern Mozambique
... the P. falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) genes have been correlated with resistance to SP in vivo ...and resistant haplotype, ...the resistant ...
7
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment naïve areas after monthly presumptive administration of three different anti malarial drugs in Liberia 1976–78
... in P. falciparum dihydrofolate reductase ...Similarly, P. falciparum dihydropteroate synthase (pfdhps) SNPs S436F/A, A437G, K540E, A581G and A613S have been associated with sulphadoxine ...
8
The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination
... with P. falciparum malaria without expressing clinical symptoms of the disease in Rufiji (see Table ...established resistant dhfr alleles are highly mobile and this observation was confirmed using ...
13
Prevalence of drug resistance associated mutations in Plasmodium vivax against sulphadoxine pyrimethamine in southern Pakistan
... dhps resistant alleles is use of co-trimethoxazole (Trimethoprim + ...In P. falciparum , complete cross resistance has been reported among sulpha drugs with variety of dhps genotypes ...of ...
9
Longitudinal Survey of Plasmodium falciparum Infection in Vietnam: Characteristics of Antimalarial Resistance and Their Associated Factors
... encodes P-gly- coprotein homologue 1 ...the resistant mutants suggested that all multiple mutants emerged through stepwise selection from the single mutant with the S108N mutation ...
8
Simvastatin Enhances Clinical Response to Sulfadoxine-Pyrimethamine in Falciparum Malaria
... sulfadoxine- pyrimethamine will create an apparent well-being but engender a tendency to chronic malaria morbidity in the study population particularly the ...
7
Adding artesunate to sulphadoxine pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa
... Sulphadoxine-pyrimethamine (SP) efficacy was assessed in 2002 in five different sites with varying intensity of malaria transmission [3]. It had a patchy distribution with an overall treatment failure at day 28 of ...
8
Effect of Plasmodium falciparum sulfadoxine pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta analysis
... In P. falciparum (Pf), SP resistance results from a series of single nucleotide polymorphisms in the parasites dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) ...
21
High efficacy of artemether lumefantrine and declining efficacy of artesunate + sulfadoxine pyrimethamine against Plasmodium falciparum in Sudan (2010–2015): evidence from in vivo and molecular marker studies
... for falciparum malaria, a number of therapeutic efficacy studies evaluated SP in Sudan, either as a monotherapy or in combination with other anti- malarials ...in resistant alleles can be an indication of ...
13
Selection for chloroquine sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia
... On the other hand, mid-gut microbiota have been reported to have direct anti-malarial properties [45-47] that could possibly impose selection on P. falciparum in the mosquito. Differences in ...
6
Molecular monitoring of Plasmodium falciparum super resistance to sulfadoxine–pyrimethamine in Tanzania
... in Muheza and Bondo sites) and in Kagera (>20 % in Muleba). This haplotype is common in South America and Cambodia [53] thus it unclear whether this has indepen- dently evolved in Tanzania or other factors such as ...
8
In vitro susceptibility to pyrimethamine of DHFR I164L single mutant Plasmodium falciparum
... of P. falciparum isolates had a single allelic form and were considered as monoclonal infection: 164L single mutant-type allele (4/13), wild-type allele (2/ 7), triple mutant-type 51I/59R/108N allele (4/9) ...
5
Efficacy of non artemisinin and artemisinin based combination therapies for uncomplicated falciparum malaria in Cameroon
... drug- resistant malaria and follow-up studies on combina- tion therapies initiated in 2001, the present series of subtrials presents the current efficacy of AQ-SP, AS- AQ, AS-SP, AS-MQ, AM-LM, AS-CD, and DH-PP ...
10
Anti malarial effect of novel chloroquine derivatives as agents for the treatment of malaria
... Changes in RBC are the most typical feature of malar- ial infections and the most common complication dur- ing malarial infection is anaemia [35]. In the present study, more than 25% loss of total RBC, haemoglobin, and ...
9