quinazolin-4-one
Synthesis of some quinazolin 4 one derivatives carrying ibuprofenyl moiety and their antiinflammatory activity
... therapeutic properties. These new drugs show comparable anti-inflammatory activity and lesser ulcerogenicity in comparison to the parent drug [4]. It is intended to exploit biochemical differences between the two ...
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CLASSICAL AND MICROWAVE IRRADIATED SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF SOME QUINAZOLIN-4-ONE SCAFFOLDS
... designed quinazolin-4-one derivatives have anticancer effect on the ...designed quinazolin-4-one moieties has given an outcome, that the binding energy of MV2 were ...
8
SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF SOME QUINAZOLIN-4-ONE DERIVATIVES
... some quinazolin-4-one derivatives have been synthesized by reacting 3-(4-acetyl phenyl)-6-iodo-2-thioxo-2,3- dihydro quinazolin-4-one with different aromatic aldehydes in ...
6
IN SILICO DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF QUINAZOLIN 4 ONE DERIVATIVES AS POTENTIAL MULTITARGET AGENTS
... In conclusion, the utilized molecular docking application of the title compounds reveals for better activity and indicating that quinazolin-4-one rings scaffold influences the pharmacological ...
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SYNTHETIC AND PHARMACOLOGICAL EVALUATION OF SOME 3 (4 {[(SUBSTITUTEDPHENYL) METHYLENE] AMINO} PHENYL) 6 BROMO 2 METHYL QUINAZOLIN 4 ONE DERIVATIVES
... Especially quinazolin-4-one motifs are having many interesting activity profiles namely EOX – 1 ...[30] Quinazolin-4-one compounds are the derivatives of quinazoline which belong ...
8
Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 2 [(8 hydroxyquinolinyl) 5 aminomethyl] 3 (4 Bromophenyl) 3(H) quinazolin 4 one
... (4-bromophenyl)-3(H)-quinazoline-4-one. This compound was finally condensed with 5-amino-8-hydroxyquinoline. The transition metal complexes of Cu 2+ , Ni 2+ , Zn 2+ , Mn 2+ and Co 2+ of this ligand ...
6
Optimization of solid phase synthesis of quinazolin 4 ones
... Optimization of microwave assisted solid phase synthesis of quinazolin-4-ones was discussed in this paper. Two step synthesis yielded in 2-methyl-4H-3,1-beznoxazin-4-one and ...
7
Electron Impact Ionization Mass Spectra of 3-Amino 5,6-Dimethoxyl-2-Methyl Quinazolin-4-(3H)-One Derivative
... Abstract: Background: The synthesis of novel heterocyclic derivatives has attracted considerable attention. The explosive growth of heterocyclic chemistry is emphasized by the large number of research publications, ...
6
Pharmacological evaluation of 3-ethyl-2-substitutedamino-3h-quinazolin-4-ones as analgesic and anti-inflammatory agents
... ethyl amine (1) with carbon disulphide and sodium hydroxide in dimethyl sulphoxide to give sodium dithiocarbamate, which was methylated with dimethyl sulfate to afford the dithiocarbamic acid methyl ester (2). Compound 2 ...
10
Synthesis and antimicrobial screening of some new N3 substituted derivatives of quinazolin 4(3H)one
... Quinazolin-4-one-3-yl-propan-2-one (2) was prepared by N-alkylation of Quinazolin-4(3H)one 1. The treatment of compound 2 with hydrazine hydrate yielded hydrazine ...
6
Synthesis and antibacterial activity of 3-amino-6-iodo-2-methyl quinazolin 4-(3H)-one and 6-iodo-2-methyl-4H-benzo [D] [1, 3] oxazin-4-one
... of 4(3H)-quinazolinone derivatives, 2,3-disubstituted derivative of quinazoline- 4-one were synthesized via the interaction of the benzoxazinone derivative with nitrogen nucleophile with the aim of ...
7
Pharmacological Potential of Some Novel Quinazolin-4(3h)-Ones
... In present study some novel derivatives of 2-(-N-substituted amino) methyl-3-(4- chlorophenyl)-quinazolin-4(3H)-ones have been synthesized by the condensation of respective 6, ...
6
Synthesis and antimicrobial activity of pyrazolyl quinazolin 4(3H)ones
... Synthesis of 2-[2-(2,6-dichlorophenyl)amino]benzyl-3-acetamido-6-iodoquinazolin-4(3H)one 4. To the solution of 3-amino-2-[2-(2,6-dichlorophenyl)amino]benzyl-6-iodoquinazolin-4(3H)one ...
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Environmentally benign synthetic approach and antimicrobial activity of Co(II) complexes of quinazolin 4(3H) one derived bidentate schiff bases
... A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Co(II) have been developed using condensation of ...
7
Microwave Assisted One Pot Synthesis of 2, 3 Di Substituted Quinazolin 4 (3h) Ones and Their Potential Biological Activity
... The 4-(3H)-quinazolinones are the formal condensation products of Anthranilic acid and amides, and they can also be prepared in this fashion through the Niementowski quinazolinone synthesis ...3-di-substituted ...
7
Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold
... at 4 °C. By centrifugation at 12,000g for 30 min at 4 °C, the lysate was clarified, the soluble supernatants were loaded onto a 5 mL Ni–NTA column (GE Healthcare, USA), and using a linear gradient of 30–350 ...
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2 (4 Fluoroanilino) 3 (2 hydroxyethyl)quinazolin 4(3H) one
... To a solution of 2–ethoxycarbonyliminophosphorane (1.27 g, 3.0 mmol) in 10 ml anhydrous THF, 4–fluorophenyl iso- cyanate (0.41 g, 3.0 mmol) was added dropwise at room temperature. The reaction mixture was left ...
7
Synthesis, Antibacterial and invitro Antioxidant Activity of 2,3 Substituted Quinazolin 4(3H) ones
... Free radical scavenging activity of the test compounds 3a-e and 4a-e were determined by the 1,1- diphenyl picryl hydrazyl (DPPH) assay method [15]. Drug stock solution (1 mg mL –1 ) was diluted to final concentrations of ...
7
Synthesis, Characterization and Biological Evaluation of Some Peptide Coupled Quinazolin-4(3h)-Ones.
... of one amino acid and the amino group of another with removal of one mole of ...between one amino acid residue and the next is called an amide bond or peptide ...
134
6,7 Dimethoxy N [3 (trifluoromethyl)phenyl]quinazolin 4 amine ethanol disolvate
... sized by the reaction of 4-chloro-6,7-dimethoxyquinazoline and 3-(trifluromethyl)aniline at 580 W in a domestic micro- wave oven and obtained in 93% yield. The bond lengths and angles are normal. Intermolecular ...
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