QUINAZOLINE DERIVATIVES
Quinazoline derivatives: synthesis and bioactivities
... for quinazoline derivatives, still in general use, including Aza-synthetic method, refluxing, oxidative cyclization, are fundamental methods for the synthesis of this important heterocyclic com- ...
15
SYNTHESIS AND CHARACTERISATION OF SOME TRIAZOLO QUINAZOLINE DERIVATIVES
... [1,2,4]triazolo[4,3-c] quinazoline derivatives were synthesized by mul- ti-component reactions of equimolar amount of 7-(substituted)-6- (substituted)-3H-quinazolin-4-one derivatives ...
6
Quinazoline Derivatives as Green Corrosion Inhibitors for Carbon Steel in Hydrochloric Acid Solutions
... Figure (2) shows the anodic and cathodic Tafel polarization curves for carbon steel in 2 M HCl in the absence and presence of varying concentrations of inhibitor 1 at 25 o C (similar curves were obtained in presence of ...
20
“In-Silico Design, Synthesis and Anti-Proliferative Evaluation of Acetidino-Quinazoline Derivatives” by Ayyappan Aravind, S Dhanya, India.
... Acetidino-quinazoline derivatives inhibiting EGFR leads to potent anticancer ...Five derivatives which obeyed rule of five and having predicted antitumor activity on EGFR were synthesized by five ...
7
QSAR, Molecular Docking and Dynamics Studies of Quinazoline Derivatives as Inhibitor of Phosphatidylinositol 3-Kinase
... Thirty-one compounds of quinazoline derivatives were taken from a reference (Zhang et al., 2015) as shown in Figure 2 and Table 1. The IC 50 values (concentration that needs for inhibition the 50 % of ...
9
Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives
... Now it was of interest to explore the scope and limitations and generality of the methyl-2-(2-thiocyana- toacetamido)benzoate (4) as a precursor for the synthesis of some polyfunctionally substituted fused ...
18
Synthesis, Characterization and Evaluation of Antifungal and Antibacterial Activities of Some Quinazoline Derivatives
... many derivatives of Quinazoline and all these derivatives have shown different pharmacological activities like anti-bacterial [3], antimicrobial [4], anti-inflammation [6], antifungal [8], ...
7
A study on synthesis, molecular properties and antimicrobial activity of some quinazoline derivatives
... quinazoline derivatives. The chemistry and pharmacology of quinazoline derivatives have been of great interest because, of its various biological ...the quinazoline nucleus and study ...
9
Quinazoline derivatives: Synthesis, and Anticancer Activity of New Derivatives against MCF 7 Cells
... for quinazoline subsidiaries, still all in all utilization, including Aza-engineered technique, refluxing, oxidative cyclization, are key strategies for the combination of this critical heterocyclic ...various ...
16
QUINAZOLINE DERIVATIVES & PHARMACOLOGICAL ACTIVITIES: A REVIEW
... (157 derivatives) against bacterial strains Escherichia coli CCM 3988,Pseudomonas aeruginosa CCM 3955, Bacillus subtilis ATCC 6663 and Staphylococcus aureus CCM 3953 by micro dilution assay was ...ten ...
12
Synthesis and biological activities of some novel substituted quinazoline derivatives
... The derivatives, synthesized are hydrazinecarbothioamide compound with 2-phenyl-4H- benzo[d][1,3]oxazin-4-one (ABP), 1-(4-oxo-2-phenylquinazolin-3(4H)-yl)thiourea (BTS), N-(4- ...
5
A NOVEL APPROACH TOWARDS DEVELOPMENT OF QUINAZOLINE DERIVATIVES IN PAIN MANAGEMENT
... Pyrazole derivatives also exhibit some similar set of activities such as antimicrobial [18] and analgesic, anti-inflammatory ...of quinazoline nucleus markedly influences the anti-inflammatory activity ...
5
Synthesis of Some Quinazoline Derivatives Functionalized with3-Heterocycles Side Chain
... quinazolinone derivatives with 3-heterocycle side ...quinazolinone derivatives 2 or ...quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone derivatives are synthesized from ...
17
A CONVENIENT SYNTHESIS OF ETHOXYPHTHALIMIDE DERIVATIZED QUINAZOLINE ASSEMBLED PYRIMIDINE AND PYRIDINE VIA COMMON INTERMEDIATE CHALCONE AND THEIR ANTIMICROBIAL AGENTS
... 18. Sasmal S, Balaji G, Kanna Reddy HR, Balasubrahmanyam D, Srinivas G, Kyasa S, Sasmal PK, Khanna I, Talwar R, Suresh J, Jadhav VP, Muzeeb S, Shashikumar D, Harinder Reddy K, Sebastian VJ, Frimurer TM, Rist Ø, Elster L, ...
14
3d qsar and molecular docking studies on anilino pyrimidine and anilino quinazolines as kinase inhibitors
... anilino pyrimidine and anilino quinazoline derivatives to inhibit the glycogen synthase kinase (GSK 3β) and EGFR tyrosine kinase respectively. The selective glycogen synthase kinase is an important for ...
6
QUINAZOLINE: UNIQUE AND VERSATILE PHARMACOPHORE IN THE FIELD OF CANCERGollapalli Naga Raju*, Nomula Venkata Naga Sai Vijaya Lakshmi, Mutyala Sai Meghana, Rama Rao NadendlaDOWNLOAD/VIEW
... compounds. Quinazoline is a bicyclic compound consisting of a pyrimidine system fused at 5, 6 with benzene ring Quinazoline is considered as an important chemical synthesis of various physiological ...
6
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NEW BAYLIS HILLMAN DERIVED CINNAMYL SUBSTITUTED QUINAZOLINONE DERIVATIVES
... quinazolinone derivatives have been synthesized by the condensation reaction between Baylis-Hillman bromides and quinazolinones in a simple and efficient manner in less reaction time with high ...substituted ...
13
Postgraduate degrees in the Pharmaceutical Sciences conferred in 2017/2018
... Synthesis and evaluation of 3,4-Dihydro-3-methyl-2(1H)- quinazoline derivatives as monoamine oxidase inhibitors Supervisor: Prof LJ Legoabe. KC Ngoy[r] ...
6
SYNTHESIS OF SOME NOVEL 4, 6-DISUBSTITUTED DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
... Quinazoline derivatives being considered as potent antimicrobial agents, several new quinazoline derivatives QZ-1 to QZ-4 were synthesized and screened for antimicrobial ...
7
Novel Chemical synthesis and medicinal aspects of some quinazoline and pyrimidine derivatives
... The quinazoline and quinazolinone skeleton is often encountered in medicinal ...of Quinazoline recognized after the synthesis of 2-methyl-1,3-aryl-4-quinazoline derivatives which acts as sleep ...
19