RA-FLS
The expression of the receptor for advanced glycation end products (RAGE) in RA FLS is induced by IL 17 via Act 1
... After the incubation, total mRNA was extracted from RA-FLS using RNAzol-B (Biotecx, Houston, TX, USA) according to the manufacturer ’ s instructions. Reverse transcription of 2 μ g of total mRNA was ...
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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis
... VEGF production is induced by IL-6 stimulation of fibroblast-like synoviocytes from patients with rheuma- toid arthritis (RA-FLS), and treatment with tocilizumab significantly l[r] ...
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A cell cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis
... in FLS results in excessive migration and reconstituting p21 is capable of reducing the exuberant migration to RA ...WT FLS with a high titer of Adp21 did not inhibit cell migration to RA SF ...
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Different expression of β subunits of the KCa1 1 channel by invasive and non invasive human fibroblast like synoviocytes
... disease. RA-FLS express ...of RA-FLS and attenuates disease severity in animal models of ...by RA-FLS may therefore provide the opportunity for generating a selective target for ...
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Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential
... -stimulated RA FLS via upregulated caveolin-mediated endocytosis, induced greater nanodrug uptake, and quickly released thera- peutic agents in the EE ...-stimulated FLS in the DEX-PEG-coated CNT ...
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Hypoxia induced miR 191 C/EBPβ signaling regulates cell proliferation and apoptosis of fibroblast like synoviocytes from patients with rheumatoid arthritis
... in RA-FLS, and knocking down of C/EBPβ promoted RA-FLS prolifera- tion ...to RA-FLS after hypoxia treatment could rescue the hypoxia-miR-191-induced phenotypes, suggesting the ...
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miR 449a inhibits cell proliferation, migration, and inflammation by regulating high mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast like synoviocytes
... in RA synovial tissue and that HMGB1 promoted cell proliferation, migration, invasion, and autophagy in RA-FLS [18, ...in RA may help us better understand the pathogenesis of ...in RA ...
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Glutaminase 1 plays a key role in the cell growth of fibroblast like synoviocytes in rheumatoid arthritis
... in RA-FLS at a mRNA level further sup- ported the notion that glutaminolysis is important in RA-FLS metabolism, although we did not confirm the upregulation of GLS1 at the protein level nor ...
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Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast like synovial cells through high mobility group box chromosomal protein 1
... rate; FLS: fibroblast- like synovial cells; HMGB1: high mobility group box chromosomal protein 1; LC3: microtubule-associated protein 1 light chain 3; LC3-II: microtubule- associated protein 1 light chain 3, type ...
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DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue derived FLS
... tissue-derived FLS [15, ...in RA fluid-derived FLS (for at least four of the five individual samples) that were consistent with respect to the direction of change reported for tissue-derived ...
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Glucose 6 phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast like synoviocytes in rheumatoid arthritis
... of RA patients compared with patients with other immune-based or non-immune-based inflammatory arthritis ...with RA, but not controls, had increased concentration of soluble GPI in their sera and synovial ...
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Metabolomic profiles of induced pluripotent stem cells derived from patients with rheumatoid arthritis and osteoarthritis
... OA FLS than RA FLS (Additional file 5: Table ...in RA FLS than OA FLS were also ...in RA FL than in OA FLS ...of RA FLS, as ATP controls the cell ...
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Effect of a small molecule inhibitor of nuclear factor κB nuclear translocation in a murine model of arthritis and cultured human synovial cells
... in RA, suppressed expression of VEGF by RA-FLS by way of suppressing activator protein-1 binding activity ...in RA therapy is the prevention of bone destruction in order to maintain normal ...
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The GTPase Rac Regulates the Proliferation and Invasion of Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients
... of RA-FLS proliferation, without affecting cell ...in RA-FLS invasion through reconstituted extracellular matrix and a less marked inhibition of two-dimensional migration as measured by ...
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Osteogenic differentiation of fibroblast like synovial cells in rheumatoid arthritis is induced by microRNA 218 through a ROBO/Slit pathway
... of RA-FLS, RA-FLS were transfected with pre-miR-218 or anti-miR-218 and the respective negative ...In RA-FLS, transfection with pre-miR-218 increased the levels of miR-218 with ...
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Akt activity protects rheumatoid synovial fibroblasts from Fas induced apoptosis by inhibition of Bid cleavage
... sensitized RA FLS to TNF-induced ...sensitizes RA FLS to TRAIL-induced apoptosis by reduction of expression of the anti-apoptotic proteins Mcl-1, XIAP, and RIP, and increase of the cell cycle ...
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Cyr61 is involved in neutrophil infiltration in joints by inducing IL 8 production by fibroblast like synoviocytes in rheumatoid arthritis
... upstream DNA flanking the IL-8 gene, and that this re- gion contains response elements for AP-1, C/EBP and NF-κB and is essential and sufficient for IL-8 expression [37,42]. To further identify the molecular mechanism ...
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Expression of interleukin 18 receptor in fibroblast like synoviocytes
... the RA-FLS cultures studied expressed at least one IL-18R chain, but the PCR analyses considered with the results of the I κ B- α assays showed that only 5 of 20 RA-FLS long-term cultures, and ...
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... Scheduling involves the distribution of scarce radio resources among the active users to satisfy their QoS needs [8, 11, 12, 13]. In literature, researches have been done on radio resource allocation in LTE downlink ...
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Patient satisfaction following transition from the original to the new formulation of subcutaneous interferon beta-1a in relapsing multiple sclerosis: a randomized, two-arm, open-label, Phase IIIb study
... the FLS component of the MSTCQ in either treatment group, indicating that FLS are not an obstacle in the transition to the new formulation of sc IFN beta-1a, and that any FLS that occur during ...
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