Rab GTPase
The Rab GTPase family
... synthesized Rab protein by a Rab escort protein (REP), which presents the Rab protein to the geranylgeranyl ...anylgeranylated Rab soluble and delivers it to the appropri- ate membrane ...of ...
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C elegans Rab GTPase activating protein TBC 2 promotes cell corpse degradation by regulating the small GTPase RAB 5
... inactivate Rab GTPases by accelerating their low intrinsic rate of GTP hydrolysis (Bernards, ...a Rab GTPase into an active GTP-bound conformation, which might result in the accumulation of cell ...
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Saccharomyces cerevisiae Rab-GDI Displacement Factor Ortholog Yip3p Forms Distinct Complexes with the Ypt1 Rab GTPase and the Reticulon Rtn1p
... binds Rab GTPases, and this finding expands the repertoire of trafficking machinery components that interact with ...the Rab GTPase Ypt1p, and future work will need to explore the interplay between ...
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Specific Rab GTPase activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
... of Rab GTPase- activating proteins (GAPs) that interfere with this ...step. Rab GAPs are characterized by a conserved catalytic domain, the TBC (Tre2/Bub2/Cdc16) domain (Strom et ...2005), Rab ...
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Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis
... infer Rab expression “footprints” of recurrent genomic amplicons in relation to risk of OSCC metastasis, recurrence and overall survival (Table ...that Rab markers are potentially relevant to OSCC ...the ...
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Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis
... In summary, we demonstrated that rLmlRAB and rLmlRABC are able to induce a predominant Th1 re- sponse in individuals immune to L. major or L. infan- tum, making this protein a potential cross-species vaccine candidate. ...
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C elegans Rab GTPase 2 is required for the degradation of apoptotic cells
... in rab-7(RNAi) animals and in the sand-1 mutant, which might suggest that the yolk needs to reach the late endosomal compartment for its later resecretion (Grant and Hirsh, 1999; Poteryaev et ...
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Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment
... The depletion of Rab43 caused an 80% reduction in the amount of infectious virus (Fig. 2C). We confirmed the siRNA duplex was working as previously published, in the absence of a working antibody, by assessing the ...
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Overexpression of a Mutant Form of EhRabA, a Unique Rab GTPase of Entamoeba histolytica, Alters Endoplasmic Reticulum Morphology and Localization of the Gal/GalNAc Adherence Lectin
... pathogenicity. Rab GTPases are proteins whose primary function is to regulate vesicle trafficking; therefore, understanding the function of Rabs in this organism may provide insight into ...such Rab, ...
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Haas, Alexander (2008): Regulation of endocytosis and secretion by Rab GTPase activating proteins. Dissertation, LMU München: Fakultät für Biologie
... specific Rab binding (Fuchs et ...this Rab is involved in the regulation of endocytosis of activated growth-factor receptors that follow the clathrin dependent pathway (Carpenter, ...the Rab and the ...
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The identification of Rab GTPase Control Systems involved in cell migration
... Rabs of the Rab8 and Rab10 families have been impli- cated in trafficking to polarized membrane domains at the cell surface (Babbey et al., 2006; Schuck et al., 2007). In budding yeast Sec4p, the Rab8 homologue is ...
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Endosome-to-plasma membrane recycling of VEGFR2 receptor tyrosine kinase regulates endothelial function and blood vessel formation.
... a Rab GTPase-dependent endosome-to-plasma membrane recycling step regulates VEGF-A-dependent intracellular signalling, cell migration, proliferation and ...
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Rab-mediated vesicle trafficking in cancer
... Phosphorylation of Rab proteins is important for vesicle targeting and traffic. Rab5a has been reported to be phosphorylated by PKCε to facilitate T-cell migration [70]. Mechanistically, phosphorylated Rab5a ...
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LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
... As major regulators of signal transduction pathways it is not unusual for protein kinases to mediate a number of biological responses. In this regard, LRRK2 may be no exception, having been linked to, among others, ...
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Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
... 20–23]. Rab GTPases, which comprise more than 60 members in the human genome, serve as multifaceted organizers in almost all membrane and vesicle trafficking processes [24, ...LRRK2-related Rab ...
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TBC1D5 controls the GTPase cycle of Rab7b
... constitutively active mutant, we next investigated whether these GAPs colocalized with Rab7b. MelJuso cells were transiently transfected with mCherry-Rab7b together with either GFP- TBC1D10A or GFP-TBC1D5, and imaged ...
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The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling
... numerous Rab-GTPases (Rab) and Rab-GTPase activating proteins (RabGAP) are capable of functional ...in Rab proteins that are predictive of their functional interaction with a specific ...
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A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis
... Abbreviations: AHA2, Arabidopsis H +-ATPase 2; ARF GTPase, ADP-ribosylation factor GTPase; AtHKT1, Arabidopsis thaliana high affinity K+ transporter 1; B, boron; BFA, brefeldin A; BHT, b[r] ...
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Genetic Analysis of Yeast Yip1p Function Reveals a Requirement for Golgi-Localized Rab Proteins and Rab-Guanine Nucleotide Dissociation Inhibitor
... with Rab-GDI for Rab protein interactions in ...and Rab GTPases cuous interaction with Rab proteins, with a specific re- render them energetically unfavorable to partition into quirement for ...
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The Jaw of the Worm: GTPase-activating Protein EAT-17 Regulates Grinder Formation in Caenorhabditis elegans
... Worms were cultured and handled as described (Sulston and Hodgkin 1988) with the following modifications. First, they were routinely grown on NGMSR plates (Avery 1993). NGMSR differs from NGM in containing 200 pg/ml ...
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