Rab-GTPases
The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling
... numerous Rab-GTPases (Rab) and Rab-GTPase activating proteins (RabGAP) are capable of functional ...in Rab proteins that are predictive of their functional interaction with a specific ...
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Modular TRAPP Complexes Regulate Intracellular Protein Trafficking Through Multiple Ypt/Rab GTPases in Saccharomyces cerevisiae
... ABSTRACT Ypt/Rab are key regulators of intracellular trafficking in all eukaryotic cells. In yeast, Ypt1 is essential for endoplasmic reticulum (ER)-to-Golgi transport, whereas Ypt31/32 regulate Golgi-to-plasma ...
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A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases
... the Rab GTPases 1a, 1b, 2a, 5c, 6a, 7, and 10. Binding of the Rab GTPases, which was validated by yeast two-hybrid binding assays, was mediated by the PieE CC1 and ...promiscuous Rab ...
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Fuchs, Evelyn (2008): Regulation of Membrane Traffic at the Golgi Apparatus by Rab GTPases and their GAPs. Dissertation, LMU München: Fakultät für Biologie
... the Rab G-domain disrupts the interaction of Switch I with GDP and facilitates the release of GDP (Delprato et ...free Rab proteins are loaded preferentially with ...affinity. Rab effector proteins ...
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Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
... the Rab of interest, but not when we overexpressed either LRRK2 or Rab ...the Rab of interest along with wild-type LRRK2, we could not de- tect any phosphorylation ...in Rab GTPases ...
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Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
... the Rab structure. More dramatically still, the Rab binding site is completely abolished by the change in helix ...the Rab makes contact with both helices of the FIP2 ...with Rab? It is ...
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Three Prevacuolar Compartment Rab GTPases Impact Candida albicans Hyphal Growth
... a Rab GTPase involved in directing vacuolar trafficking through the late endosomal prevacuolar compartment ...Vps21p-related GTPases, Ypt52p and Ypt53p, that colocalize with Vps21p and can suppress the ...
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Structural biology of arf and rab GTPases' effector recruitment and specificity
... Another common mode of binding observed for Arf/Rab effec- tors is the formation of b-b zipping interactions made with the b2 strand of the interswitch. Three examples highlight this mode of binding in the ...
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Structural aspects of the regulation of Parkinson's Disease associated LRRK2 Kinase by Rab GTPases
... derivatives, Rab proteins can be easily labelled for this technique, and the mant (N-‐Methylanthraniloyl) modified guanine nucleotides were chosen for this ...and Rab proteins were exchanged with ...
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Gluten quality of bread wheat is associated with activity of RabD GTPases
... RabD GTPases mediate ER-to-Golgi vesicle ...for Rab GTPases in Arabidopsis, rice, Brachypodium and bread wheat was compiled and compared to identify wheat RabD ...
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Rab-mediated vesicle trafficking in cancer
... small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking ...Specific Rab protein together with ...
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Saccharomyces cerevisiae Rab-GDI Displacement Factor Ortholog Yip3p Forms Distinct Complexes with the Ypt1 Rab GTPase and the Reticulon Rtn1p
... synthesized Rab is delivered to cellular membranes in a dimeric complex with a Rab-specific chaperone, Rab escort protein ...However, Rab is only tran- siently associated with its resident ...
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The identification of Rab GTPase Control Systems involved in cell migration
... Le, T.L., Yap, A.S., and Stow, J.L. (1999). Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J. Cell Biol. 146, 219–232. Levivier, E., Goud, B., Souchet, M., Calmels, T.P., Mornon, J.P., ...
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The Rab GTPase family
... Many Rab GTPases seem to be products of gene duplica- tions, given that several subfamilies of closely related Rab GTPases (isoforms) with 75-95% sequence identity and overlapping functions ...
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Structure function analyses of the interactions between Rab11 and Rab14 small GTPases with their shared effector Rab coupling protein (RCP)
... Rab GTPases recruit effector proteins, via their GTP-depen- dent switch regions, to distinct subcellular ...small GTPases that bind to common effectors termed the Rab11 family of interacting pro- ...
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The cytoplasmic domain of chondrolectin interacts with the β-subunit of rab geranylgeranyl transferase
... the Rab GTPases [15]. A few Rab GTPases possess a CAAX motif and are modified by a single geranylgeranyl moiety ...for Rab geranylgeranyl ...
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C elegans Rab GTPase activating protein TBC 2 promotes cell corpse degradation by regulating the small GTPase RAB 5
... inactivate Rab GTPases by accelerating their low intrinsic rate of GTP hydrolysis (Bernards, ...a Rab GTPase into an active GTP-bound conformation, which might result in the accumulation of cell ...
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Genetic Analysis of Yeast Yip1p Function Reveals a Requirement for Golgi-Localized Rab Proteins and Rab-Guanine Nucleotide Dissociation Inhibitor
... with Rab-GDI for Rab protein interactions in ...small GTPases are YIP1 is an essential gene in Saccharomyces cerevsiae and commonly found to cycle between a cytosolic pool and a extremely well ...
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Rac and Rho GTPases in cancer cell motility control
... The Rac subfamily of Rho GTPases includes Rac1, Rac2, Rac3. Rac1 is over-expressed in various tumors and accumulating evidence indicate that Rac1-depen- dent cell signalling is important for malignant transfor- ...
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The involvement of Rho GTPases in plexin mediated signal transduction
... A growing body of evidence supports the view that Rho GTPases regulate axon outgrowth and guidance. Transgenic Drosophila with mutations in Rac or Cdc42 suffer failures in axon initiation and elongation and ...
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