Racemic mixture
Simulation of Separation of a Racemic Mixture of Ibuprofen by Supercritical Fluid Chromatography in Simulated Moving Bed
... a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chroma-tography in a simulated moving bed (SFC-SMB) is investigated by ...
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In situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011
... There is much imbalance between the activities of RCR and SCR, resulting in a low biotransformation efficiency of racemic (R,S)-PED to its (S)-isomer by C. parapsilosis. In this work, we designed an in situ ...
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Effects of Racemic Nebivolol and Its Stereoisomers on Rat Aortic Segments in Two Age Groups
... by racemic, D-, and L-nebivolol in phenylephrine-contracted rat aortic rings, we did not find any differences among the relaxation ...the racemic mixture did not differ in preparations with and ...
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Development of QSAR model for immunomodulatory activity of natural coumarinolignoids
... In the present study, we screen out potential anti-inflam- matory and immunomodulatory compound cleomiscosin-B from the isolated racemic mixture of three cleomiscosin isoforms through quantitative structure ...
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The mono (S) α methylbenzylammonium salt of (R) homocitric lactone
... a racemic mixture of lactones as the diastereomeric salt to separate the R anion, which is formed by the loss of a proton from the carboxylic acid group on the 2-position of the lactone ...
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HPLC Method Development and Validation of S( ) Carvedilol from API and Formulations
... the racemic mixture of Carvedilol is administered clinically, β-adrenoceptor blocking activity of the S(-)-enantiomer is about 200-fold higher than that of the R(+)-enantiomer while the α1-adrenoceptor ...
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Crystal structure of cis bis{4 phenyl 1 [(3R) 1,7,7 trimethyl 2 oxobicyclo[2 2 1]heptan 3 ylidene]thiosemicarbazidato κ3O,N1,S}cadmium(II) with an unknown solvent molecule
... complex with the R,S-camphor-4-phenylthiosemicarbazone, a derivative from a racemic mixture of camphor. In the title compound the molecular structure matches the asymmetric unit and the metal ion is ...
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Homochirality as the signature of life: the SETH Cigar
... Left- and right-handed mirror image molecules rotate the plane of polarized light by equal amounts in opposite directions, so for a racemic mixture there is zero[r] ...
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Chemoenzymatic Kinetic resolution of (R)-malathion in aqueous media
... the racemic mixture, an enantioselective hydrolysis of (R,S)-malathion into (S)-malathion monocarboxylic acid and (R)-malathion was evaluated using Mucor javanicus Lipase, Candida rugosa Lipase and Porcine ...
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Comparative Study of Racemic Salbutamol and Levosalbutamol in patients with Bronchial Asthma
... a racemic mixture, although beta-2 agonist activity resides almost exclusively in the ...of racemic salbatamol while the (S)-enantiomer is inactive and this may be associated with airway hyper ...
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Enantioselective Conversion of Racemic Sotalol to R(-)-Sotalol by Lipase AP6
... all selected microorganisms were added with 100 µl of racemic sotalol solution (2.5 mg/ml in methanol), which was previously sterilized by passing through syringe driven sterile PVDF hydrophilic membrane filters ...
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Coupling Viedma ripening with racemic crystal transformations : mechanism of deracemization
... h), racemic crystals still exist, but significant mass of counter enantiomer conglomerate phase has also nucleated (Table ...remaining racemic crystals and growth of the preferred ...the racemic ...
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Racemic cis bis(2,2′ bipyridyl)difluorovanadium(III) tetrafluoroborate
... The cations are linked into centrosymmetric pairs by means of a single aromatic π–π stacking interaction. The bipyridyl rings N11/C12–C16 at (x, y, z) and N21/C22–C26 at (1 − x, 1 − y, −z) are almost parallel, with a ...
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Racemic mefloquinium chlorodifluoroacetate: crystal structure and Hirshfeld surface analysis
... Kryptoracemic behaviour is rare and is found in only 0.1% of all organic structures (Fa´bia´n & Brock, 2010). This observa- tion clearly implies that 99.9% of racemic compounds, mol- ecules with meso symmetry ...
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Racemic 1,1′ bi 2 naphthol dimethylformamide sesquisolvate: a redetermination
... Racemic 1,1′-bi-2-naphthol (0.29 g, 1 mmol) was dissolved in a mixed solvent system of water (5 ml) and dimethyl- formamide (5 ml). This solution was added to an ethanol solution (10 ml) of 2-aminopyrimidine (0.19 ...
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A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF RACEMIC SALBUTAMOL AND LEVOSALBUTAMOL IN PATIENTS WITH ASTHMA
... the racemic salbutamol group (group A) and 50 patients were allocated to levosalbutamol group (group ...from racemic salbutamol group and five patients from levosalbutamol group were lost to ...from ...
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Progress Toward the Asymmetric Synthesis of (-)-Gephyrotoxin
... (-)-(3R, 9R)-5-(Diethoxyphosphoryl)-3-(2' -tert-butyl-diphenylsilyloxyethyl)-5,6 dihydro-7-indolizidinone (65). To a stirred mixture of 64 (43.2 mg, 0.079 mmol, 1 eq) and triethylphosphite (203 l, 1.187 mmol, 15 ...
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Enzyme Mediated Enantioselective Hydrolysis of Aliphatic Dicarboxylic Acid Diesters
... The enzyme-mediated kinetic resolution of racemic alcohols and esters is one of the at- tractive methods for the preparation of optically active compounds [1] [2] [3] [4]. In our previous study, we succeeded in ...
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Catalytic Promiscuity of Transaminases : Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination
... Then, it was investigated if this reaction could be performed enantioselectively. Ideally, a kinetic resolution via tandem hydrodefluorination-deamination could be achieved (Scheme 1c). A series of transaminases ...
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Evidence behind use of levosalbutamol over salbutamol to prevent cardiac side effects
... Kelly et al, did a retrospective chart review of patients with congenital heart disease and arrhythmia comparing the change in heart rate with racemic RS and LS. They analyzed 192 patients of whom 142 received LS, ...
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