Radiation Induced DNA Damage
The immunological consequences of radiation-induced DNA damage.
... the radiation field which are, at least in part, immunologically-mediated ...by radiation-induced DNA damage ...nuclear DNA above an unspecified threshold that the cell is ...
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Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy
... for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK Received 24 April 2013; accepted 12 June 2013 Abstract DNA damage of exposed tumour tissue leading to cell ...
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Evaluation of gamma radiation-induced DNA damage in Aedes aegypti using the comet assay
... subcellular damage in living organisms (Garrison and Uyeki, 1988). Radiation, which acts on the cellular components, breaks chemical bonds (and also DNA DSBs) and provokes the production of free ...
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Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases
... to DNA damage exist at the G 1 /S and G 2 /M ...damaged DNA. Cells have developed multiple DNA repair pathways to protect themselves from different types of DNA ...Oxidative DNA ...
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Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation induced DNA damage in lymphocytes
... Discussion In this study, early and late complications in normal tissue were assessed at an arbitrary single point. In this situation, a relative scale of normal tissue reactions, such as the score system pro- posed by ...
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PROTECTION OF LOW LET RADIATION INDUCED DNA DAMAGE IN RAT BONE MARROW CELLS BY FREE RADICAL SCAVENGER CURCUMIN
... However, oxidative stress is generated when free radicals are generated as a result of a depletion of antioxidant levels. In recent decades, phytochemical constituents have received much attention due to their potential ...
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Aloe Vera Protects Radiation Induced DNA Damage In Mouse
... jejunal DNA was found to be minimum in all control and experimental sets of animals at day 1 but it was significantly higher ...Later DNA contents increased continuously in all sets of control and ...
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Excision repair of UV radiation-induced DNA damage in Caenorhabditis elegans.
... Since the radia- tion hypersensitivities of these mutants vary dramati- cally throughout development (HARTMAN 1984a,b), repair was measured in embryos (irradiated 6 hr af[r] ...
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Review Article Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair
... Recently, our group analysed the response to IR exposure in sporadic BC patients and healthy controls by measuring DNA damage through alkaline Comet assay [35]. We did not observe a great interindividual ...
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Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response
... The HR system uses homologue DNA sequence as an undamaged matrix (template), thus enabling correct repair and end-joining of DNA. HR is very accurate repair me- chanism and it is processed from late S-phase ...
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Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
... human colorectal cancer cells [5]. Meanwhile, Chen group reported the radiosensitization of ruthenium complexes comprising benzimidazolyl group [6, 7] and selenium element [8]. Very recently, Gill and co-workers ...
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Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells
... Radiotherapy is always on a sharp edge in killing the tumors and limiting the survival of critically important adjacent normal tissues. Currently available radioprotec- tive agents are non-specific and not fulfilling the ...
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RNA interference to enhance radiation therapy: targeting the DNA damage response
... of radiation induced DNA damage whilst simultaneously using RNAi to disable the remaining functioning DDR pathways leads to an overwhelmingly and lethal amount of DNA damage to ...
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Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
... the DNA-damaging modalities of certain chemo- and radiotherapeutic regimens, such patients face the collateral outcome of premature loss of fertility and ovarian endocrine ...oocyte DNA damage ...
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Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
... ionizing radiation. Radiotherapy regimes mostly use X- and gamma radiation (Masuda and Kamiya, ...2012). Radiation affects tumor and healthy irradiated cells ...2005). Radiation therapy can be ...
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Radiation-induced tissue damage and response.
... of radiation-induced in flamma- tion [81] is beyond the scope of this review, but is rele- vant to radiation-induced tissue damage (Figure ...involves damage-associated molec- ...
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DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels
... 1.3. DNA Damage 1.3.1. Principles DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer and cellular or organismic death ...in DNA (Figure ...
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EFFECT OF PROPOLIS AND ITS POLYPHENOLIC/FLAVONOIDS COMPOUNDS ON DNA DAMAGE INDUCED BY RADIATION TO MOUSE LYMPHOCYTES
... examined DNA damage of lymphocytes using the single-cell gel electophoresis assay (comet ...of DNA damage of lymphocytes as compared with unradiated ...oxidative DNA damage of ...
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Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellular DNA damage
... required for optimal antioxidant potency in vitro and in cell- based systems. Therefore, the interplay of hydrophilic and hydrophobic characteristics, together with the flavonoid struc- ture, especially the number and ...
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Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation
... Ultraviolet radiation; UV Abstract Exposure to ultraviolet (UV) radiation is associated with approximately 65% of mel- anoma cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell ...
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