Radium-223 dichloride
Radium-223 dichloride: illustrating the benefits of a multidisciplinary approach for patients with metastatic castration-resistant prostate cancer
... of radium-223 dichloride (radium-223) into the treatment algorithm for men with mCRPC and symptomatic bone ...metastases. Radium-223 is a new treatment that, unlike ...
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Radium 223 dichloride for prostate cancer treatment
... death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone ...lesions. Radium-223 dichloride has been approved for the treatment of metastatic ...
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A phase IIa, nonrandomized study of radium-223 dichloride in advanced breast cancer patients with bone-dominant disease
... Radium-223 dichloride (radium-223) is an alpha-emit- ting pharmaceutical that is Food and Drug Administration (FDA) approved for the treatment of patients with castra- tion-resistant ...
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Effect of radium-223 dichloride (Ra-223) on hospitalisation: An analysis from the phase 3 randomised Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial.
... overall, radium-223 patients experienced fewer events than placebo patients (33% versus 38%, respectively) and median time to first SSE ...for radium-223 ...and radium-223 on ...
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Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial.
... metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; under- standing risk factors will improve clinical decision ...of radium-223 in ALSYMPCA and ...
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Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial.
... Statistical methods used in ALSYMPCA have been described. 11,19 Descriptive statistics (n, mean, standard deviation, minimum, median, and maximum values) were presented for clinical laboratory tests (hematology and ...
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Efficacy and Safety of Radium-223 Dichloride in Symptomatic Castration-resistant Prostate Cancer Patients With or Without Baseline Opioid Use From the Phase 3 ALSYMPCA Trial.
... group]). Radium-223 significantly prolonged OS versus placebo in nonopioid (hazard ratio [HR] = ...with radium-223 versus placebo (HR = ...Conclusions: Radium-223 versus placebo ...
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Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial.
... of radium-223 and placebo patients who received anticancer medications and radiotherapies during follow-up were generally ...long-term radium-223 safety may be difficult given that many ...
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Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone
... Ra-223 dichloride can be adminis- tered without toxicity in a patient with hormone-refractory bone metastasis from breast cancer at the US FDA– approved dose for prostate ...Ra-223 dichloride ...
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The safety and efficacy of radium-223 dichloride for the treatment of advanced prostate cancer.
... of radium- 223 with placebo in men with CRPC and bone metastases ...of radium-223 and best supportive care (BSC) or placebo and BSC every 4 weeks to a total of six ...with radium- ...
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Can bone scans guide therapy with radium-223 dichloride for prostate cancer bone metastases?
... Results: Twenty patients were treated with Ra-223 dichloride. Twelve patients had innumer- able bone metastases, three patients had super scans, and three patients had two to seven bone lesions. Two ...
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Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review.
... application. Radium 223 dichloride is the first-in-class, commercially available targeted alpha therapy approved for the treatment of patients with ...
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Development of sodium fluoride PET response criteria for solid tumours (NAFCIST) in a clinical trial of radium-223 in osteosarcoma: from RECIST to PERCIST to NAFCIST
... bone-forming component of osteosarcoma. We have shown that NAFCIST correlated with changes in bone alkaline phosphatase level, a tumour marker in osteosar- coma. More importantly we have shown that NAFCIST and not ...
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Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study
... of radium-223 and paclitaxel, and it was also the first to enroll patients with solid tumors not previously studied with radium- 223 ...of radium-223 and pacli- taxel in cancer ...
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Application of the HTA Core Model for complex evaluation of the effectiveness and quality of Radium-223 treatment in patients with metastatic castration resistant prostate cancer
... with Radium-223 at the INMM in order to improve the quality of the thera- peutic ...the Radium-223 administered is almost ...the Radium-223 administration, especially towards ...
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An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223.
... of radium-223 versus placebo, each plus best standard of care, in castration-resistant prostate cancer (CRPC) patients with symptomatic bone metastases (Parker et ...of radium-223 (50 kBq/kg ...
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Tirichter, Natalia (2019): Radium-223-dichlorid beim ossär metastasierten Prostatakarzinom in der klinischen Routine. Dissertation, LMU München: Medizinische Fakultät
... notwendig machte, ein weiterer Patient eine Thrombopenie (70.000/µl) sowie eine Leukopenie (1,7 G/l). Ein weiterer Patient entwickelte eine Panzytopenie (Hb 8,1 g/dl, Leukozyten 2,7 G/l, Thrombozyten 90.000/µl), in der ...
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Radium Activity Levels in Groundwater in Saudi Arabia, and Relationship with Some Water Chemical Constituents.
... total radium in the investigated groundwater samples were found to be strongly associated with the decrease in the dissolved oxygen content of water, as presented in ...more radium is expected in ...
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Study of Radionuclides and Radon Exhalation Rate in Soil and Sand Samples from Tiba, Luxor, Governorate
... DOI: 10.4236/wjnst.2019.92006 85 World Journal of Nuclear Science and Technology information in the monitoring of environmental contamination by natural ra- dioactivity. Nationwide surveys have been carried out to ...
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Biguanidinium dichloride
... Data collection: CrysAlis CCD Oxford Diffraction, 2006; cell refinement: CrysAlis RED Oxford Diffraction, 2006; data reduction: CrysAlis RED; programs used to solve structure: SIR97 Alto[r] ...
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