Rapid disease progression
Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV 1 infection
... Low CD1c + mDC counts (<10 cells/μL) were asso- ciated with an increased risk of more rapid disease progression. The patients with low CD1c + mDC counts had 4-fold higher odds of rapid ...
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ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele
... to rapid disease progression through acquired chromosome 11q deletions, loss of ATM activity and clonal expansion ...advanced disease, via selection for 11q deletion and inclusion of CLL4 ...
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Macaques with Rapid Disease Progression and Simian Immunodeficiency Virus Encephalitis Have a Unique Cytokine Profile in Peripheral Lymphoid Tissues
... if rapid disease progression in SIV-infected an- imals was associated with a specific cytokine response, cytokine mRNAs were compared for animals with rapid (n ⫽ 16) and slow/normal (n ⫽ 12) ...
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CD4+-T-Cell and CD20+-B-Cell Changes Predict Rapid Disease Progression after Simian-Human Immunodeficiency Virus Infection in Macaques
... analysis. Rapid and sustained CD4 loss, CD20 cell loss, a low level of virus- binding antibody, a low level of neutralizing antibody, and a high degree of plasma antigenemia (at 2 weeks) were all pre- dictive of ...
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Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression
... These studies also provide strong evidence that CTL clonal deletion is not the predictable result of persistent high-level viremia in late-stage HIV-1 infection. In murine lymphocytic choriomeningitis virus infection, ...
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A prospective natural history study of Krabbe disease in a patient cohort with onset between 6 months and 3 years of life
... experienced rapid disease progression, and failed to gain any functional skills following initial signs and symptoms of ...severe disease versus a more mild ...
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Alterations in Cardiac and Pulmonary Function in Pediatric Rapid Human Immunodeficiency Virus Type 1 Disease Progressors
... Conclusions. Rapid disease progression in HIV-1- infected infants is associated with significant alterations in heart and lung function: increased respiratory rate, increased heart rate, and ...
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The immunology of neurodegeneration
... Increased plaque load and neurodegeneration Increased plaque load and neurodegeneration More rapid disease progression Increased Aβ levels, decreased survival Increased plaque load and m[r] ...
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Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use
... to rapid dis- ease ...for rapid progression were elevated LDH, a PS of 1 and the presence of brain ...for rapid disease ...upon disease pro- gression, there was no correlation ...
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Acute depletion of activated memory B cells involves the PD 1 pathway in rapidly progressing SIV infected macaques
... of rapid progression to AIDS following HIV-1 infection remains poorly understood, despite more than 2 decades of intensive ...study. Rapid disease progression has been substan- tially ...
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Serum vitamin d in patients of hiv/aids & its coorelation with cd4 Count& art treatment
... more rapid disease progression observed in HIV-infected persons with low levels of vitamin D or with genetic variants within the vitamin D receptor that alter binding to vitamin ...
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SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
... slower progression of SIV infection in Chinese RM may be a result of a block in entry by increased CCL3L in these animals ...the rapid disease progression during both acute and chronic ...
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Clinical patterns in Parkinson's disease
... underlying disease mechanisms and the development of tailored treatment ...or progression-related variables provide the opportunity to obtain conceptually clear ...of disease onset, and rate of ...
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<p>Challenges and Opportunities in Atypical Parkinsonian Syndromes: Call to Action</p>
... s disease due to similar signs and ...by rapid disease progression and decreased life ...and rapid functional ...effective disease management of atypical Parkinsonian syndromes ...
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Survival, Disease Manifestations, and Early Predictors of Disease Progression Among Children With Perinatal Human Immunodeficiency Virus Infection in Thailand
... of rapid disease progression provides useful information for counsel- ing families about a child’s prognosis and for making decisions about clinical management, we examined the relationships between ...
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Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease.
... of disease outcome within their first months of life: some develop severe symptoms of disease and rapidly progress to AIDS, while others show a variable period of clinical ...two rapid- and three ...
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Predicting progression of Alzheimer's disease
... time, slow progressors gained 0.6 fewer points per year, and intermediate progressors gained 0.8 fewer points per year. Figure 1 shows that both of these groups diverged from the fast group over time. Similarly, slow ...
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Clinical Predictors of disease progression in Parkinson's disease
... as disease duration, and H&Y stage or PIGD, would also have emerged as independent risk factors, but these factors apparently shared too much variance with age, EDS and daily levodopa dose to make a ...
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High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease
... s disease,” “cerebrospinal fluid,” and ...and progression in the dementia stage of AD, we found seven longitudinal studies, and the results were ...Alzheimer’s Disease Neuroimaging Ini- tiative ...
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Effect of childbirth on the course of Crohn's disease; results from a retrospective cohort study in the Netherlands
... the disease, i.e. year of diagnosis, diagnostic tools, disease localization, perianal involvement (fistula and/or abscesses), current medication, surgery, and questions about fertility, number and outcome ...
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