ras(1–171) protein
Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies
... of Ras protein pairs that are similar in sequence but separated from each other in the interactome (Panel III in Figure 4) contrasts with the abundance of highly divergent Ras pairs close in the ...
17
Regulation of p53 oligomerization by Ras superfamily protein RBEL1A
... novel Ras- superfamily protein, namely RBEL1A ...glycosylated protein that harbors a Ras/Rab-like GTPase domain at its N-terminus ...p53 protein ubiquitination and degradation ...
10
IN SILICO MODELING OF MONOMERIC DEXAMETHASONE INDUCED RAS RELATED PROTEIN 1 AND RAS HOMOLOG ENRICHED IN STRIATUM: ROLE OF N TERMINUS AND STRUCTURE‑FUNCTION RELATIONSHIP
... Dexamethasone-induced Ras-related protein 1 (Dexras1) (also known as AGS1 or Rasd1) and Ras homolog enriched in striatum (RHES) (also known as Rasd2) are the monomeric G proteins, which are ...
7
Cytotoxic T lymphocyte responses to Ras protein
... of Ras on cell surface MHC ...p21Ras protein as murine leukemia virus (MLV) lacking the Ki-ras gene, did not cause reduced cell surface class II expression ...the Ras oncogene family reduce ...
217
Divergent roles for Ras and Rap in the activation of p38 mitogen activated protein kinase by interleukin 1
... proteins Ras, Rap, and Rac, inhibits the acti- vation of p38 mitogen-activated protein kinase (MAPK) by interleukin-1 (IL-1) in ...target protein involved appeared to be Ras, ...
8
Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for Its Genome Replication
... Reduction of G3BP1 levels reduces HCV replication and infection. Since G3BP1 is localized to HCV RCs, we wondered whether it modulates RC formation or viral RNA replication. To address this, we examined HCV replication ...
9
Human T-Lymphotropic Virus Type 1 Mitochondrion-Localizing Protein p13II Sensitizes Jurkat T Cells to Ras-Mediated Apoptosis
... with 1 ml fresh ...antibodies, 1 g each of a mouse anti-human CD3 monoclonal antibody (clone HIT3a) and a mouse anti-human CD28 monoclonal antibody (clone ...
9
EVALUATION OF HYPERMETHYLATION OF RAS ASSOCIATION DOMAIN FAMILY-1 A AND GLUTATHIONE S-TRANSFERASE PROTEIN-1 GENES AS DIAGNOSTIC MARKER FOR HEPATOCELLULAR CARCINOMA
... The molecular pathogenesis of HCC involves well-defined genetic and epigenetic alterations (2).A few number of genetic lesions have been identified in the molecular mechanisms of hepatocarcinogenesis such as p53 and Rb ...
13
The Role of Tyrosine Phosphorylation in Regulation of Signal Transduction Pathways in Unicellular Eukaryotes
... by Ras involves both its direct binding to the enzyme and the participation of the adenylyl cyclase-associated protein, Srv2p (Shima et ...2000). Ras is activated by the GEF, Cdc25, with cdc25 null ...
24
Impact of Mutations on K Ras p120GAP Interaction
... The Ras proteins, H-, N- and K-Ras, are low molecular weight GTPases that play important roles in signal transduction of cell proliferation and/or differentiation ...state, Ras binds guanosine ...
9
Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
... the protein kinase fold, the histidine kinase/HSP90/Topo II fold, the HSP70/RNAse H Fold and the mononucleotide binding fold/P-loop NTPases ...the Ras small GTPases [11, ...
174
Substitution of ras for the Herpesvirus Saimiri STP Oncogene in Lymphocyte Transformation
... processes. Ras is a plasma membrane-as- sociated guanine nucleotide-binding protein that cycles be- tween a GDP-bound form and a GTP-bound form (2, ...of Ras display an increased propor- tion of ...
7
Use of a hybrid protein consisting of the variable region of the Borrelia burgdorferi flagellin and part of the 83 kDa protein as antigen for serodiagnosis of Lyme disease
... Use of a Hybrid Protein Consisting of the Variable Region of the Borrelia burgdorferi Flagellin and Part of the 83-kDa Protein as Antigen for Serodiagnosis of Lyme Disease CHRISTIANE RAS[r] ...
7
DNA methylation biomarkers for hepatocellular carcinoma
... PPI: protein-protein interaction; RASSF1A: Ras association domain family 1 isoform A; GEO: gene expression omnibus; KEGG: Kyoto Encyclopedia of Genes and Genomes; STRING: Search Tool for the ...
13
Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration
... active Ras-related protein 1 (Rap1), another small GTPase, in RPE can strengthen the RPE barrier integrity and can resist CEC transmigration of the RPE, suggesting Rap1 activation may be another ...
10
The regulation of TGFβ signal transduction
... morphogenetic protein), Erk (extracellular signal-regulated kinase), LIMK2 (LIM domain kinase 2), JNK (Jun N- terminal kinase), p38 (p38 MAPK), PAR6 (partitioning-defective 6 homolog), Rho (Ras homolog), ...
16
WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... identified RAS- binding protein that mediates RAS degradation [19], in the suppression of CRC, especially that related with the K-RAS mutation-induced activation of ...of RAS, thus ...
13
Regulation and functional analysis of EphA2 in normal and Ras-transformed mammary epithelium
... ephrinB 1- expressing axons by EphB2 extracellular domain-expressing cells in the adjacent territory (Henkemeyer et a l, ...raft protein (Huai and Drescher, ...kDa protein following EphAS treatment ...
345
Index Catalog // Carolina Digital Repository
... oncogenesis, Ras signals primarily through the Raf kinase, phosphatidylinositol-3 kinase, and Ral-specific guanine nucleotide exchange factor (RalGEF) downstream ...mitogen-activated protein kinase (MAPK) ...
149
Current understanding of reovirus oncolysis mechanisms
... of Ras transformation on reovirus ...of protein synthesis. in Ras-transformed cells, viral uncoating during cell entry is enhanced by higher levels of cathepsins, viral protein synthesis is ...
11