rat aortic smooth muscle cell
Repair of protease damaged elastin in neonatal rat aortic smooth muscle cell cultures
... The objective of this study was to investigate the elastin repair process in the rat aortic smooth muscle cell culture after proteolytic injury. Although little studied in vivo, elastin ...
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Original Article PDGF-BB activated Rac1 in regulation of inner and outer nuclear distribution of rat aortic smooth muscle cell β-catenin
... vascular smooth muscle cells ...vascular smooth muscle cells prolif- eration and migration ...ed cell proliferation and embryonic limbs ...vascular smooth muscle cells’ ...
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Nitric oxide inhibits angiotensin II induced migration of rat aortic smooth muscle cell Role of cyclic nucleotides and angiotensin1 receptors
... vascular smooth muscle cell (SMC) ...of rat SMCs was evaluated using a modified Boydens Chamber (transwell inserts with gelatin-coated polycarbonate membranes, 8 microns pore ...
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Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells
... The application of cyclic stretch to cultured VSMCs has been widely used as an in vitro experiment to study mo- lecular events in response to mechanical overload [16-20]. It has previously been reported that cyclic ...
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Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo
... RASM cell–secreted mitogen since a different lot of the antibody, AD930826, raised against a sim- ilar antigen and obtained from the same supplier, demon- strated only a slight decrease in the mitogenic activity ...
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Original Article Chinese rice wine polyphenol compounds inhibit vascular smooth muscle cell dedifferentiation and its mechanism
... inhibit rat aortic vascular smooth muscle cells (VSMCs) dedifferentiation through mammalian target of rapamycin (mTOR)/P70S6K ...of rat VSMCs was conducted and VSMCs in passages 3-5 ...
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Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
... of smooth muscle cell (SMC) proliferation that contributes to post angioplasty ...cultured rat aortic SMC, stimulating an increase in 3H-thymidine incorporation, as well as an increase ...
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Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells
... and cell replication in cultured rat aortic smooth muscle ...increases cell number (approximately twofold) in these cultures but suppresses [3H]thymidine incorporation and ...
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VEGF B inhibits apoptosis via VEGFR 1–mediated suppression of the expression of BH3 only protein genes in mice and rats
... primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the ...
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Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts
... Inbred DA (AG-B4, RT1a) and WF (AG-B2, RT1v) rats were used as donors and recipients of aortic allografts. The recipient rats were inoculated i.p. either on day 1 (early infection) or on day 60 (late infection) ...
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Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity
... Acute aortic dissection typically occurs when a small tear in the intimal layer allows blood to enter into the medial space, which itself is often diseased and contains degraded elastin and reduced SMC ...Acute ...
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The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
... 3-deficient cell populations to osteopontin was only half that of cells containing alpha v beta 3, and migration toward an osteopontin gradient in the Boyden chamber was dependent on cell surface alpha v ...
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Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin C antisense prevents progression, of vascular disease
... Preparation of sense and antisense vectors for transfection. A U1Bam pZeo mut EcoRI/SpeI expression vector backbone was a gift from H.C. Dietz and R.A. Montgomery (Johns Hopkins University School of Medicine, Baltimore, ...
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Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
... abdominal aortic wall) was obtained from patients undergoing open repair of the infra-renal abdominal aortic aneurysm, and SV fragments obtained from age-and sex-matched patients undergoing coronary artery ...
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Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat
... contributing to the development of the neointimal fibroproliferative lesion. Taxol was found to interfere both with platelet-derived growth factor-stimulated VSMC migration and with VSMC migration and with VSMC ...
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Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
... Accelerated vascular aging, cell senescence and syn- thetic SMC phenotypes have been documented in AAA patients or those with risk factors for AAA [11,12,32,33]. Another common feature of aged cells is that of ...
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Extent of Degenerative Changes in Ascending Aorta of Patients with Bicuspid Aortic Valve (BAV)—A Histopathological Study
... the aortic sinuses and proximal as- cending aorta or even the distal ascending aorta is also involved? In clinical practice, as resection only involves the sinuses and proximal aorta, if fulfills the criterion of ...
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Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis Alpha smooth muscle actin is a marker of mesangial cell proliferation
... Mesangial cell proliferation is common in glomerulonephritis but it is unclear if proliferation is associated with any in vivo alteration in ...alpha-smooth muscle actin in a mesangial pattern, ...
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Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media
... of smooth muscle cells of rat and human aortic media shows a predominance of the ...experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured ...
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Sustained inhibition of intimal thickening In vitro and in vivo effects of polymeric beta cyclodextrin sulfate
... of rat aortic smooth muscle cells with an insoluble, sulfated polymer of beta-cyclodextrin (P-CDS) was associated with a dose-dependent inhibition of proliferation induced by fetal calf serum, ...
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