Rat hepatocytes
Hepatitis B Virus HBx Protein Localizes to Mitochondria in Primary Rat Hepatocytes and Modulates Mitochondrial Membrane Potential
... primary rat hepatocytes ...of hepatocytes, which is comparable to previous reports in which CCCP was used to induce depolarization (54, ...primary rat hepatocytes protected cells from ...
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In Vitro Hepatoprotective Activity of Justicia Gendarussa Stem on Isolated Rat Hepatocytes
... Isolated rat primary hepatocytes were used as in-vitro model to evaluate the hepatoprotective activity of methanolic extract of Justicia gendarussa ...primary rat hepatocytes were incubated ...
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N 3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes
... When rat hepatocytes were incubated with albumin complexed to the n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), rather than to oleic acid (OA), the secretion of newly ...
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A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method
... in rat hepatocytes and its inhibition by CsA given the models fits and parameter ...in rat hepatocytes was supported as the best fit- ting model to the data (Model ...in hepatocytes; ...
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Original Article ITE enhances the CYP450s activities of rat hepatocytes in a bioreactor
... liver since they play essential roles in drug clearance [15-18]. Numerous studies have de- monstrated that AhR regulated all CYP450 en- zymes that were also induced by aromatic hy- drocarbons such as TCDD and ...
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NAADP-sensitive Сa(2+) stores in permeabilized rat hepatocytes
... Intracellular solution contained (mM): 20 NaCl, 120 KCl, 1.13 MgCl 2 , 1.3 CaCl 2 , 10.0 HEPES, 5 µg/ml oligomycine, 1 µg/ml rotenone and 2.0 АТP (рН 7.0). All experimental procedures were carried out at 37 ºС. In order ...
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Short-term Chelating Efficacy of Deferoxamine in Iron Overloaded Rat Hepatocytes
... Iron-loaded rat hepatocytes was ...in hepatocytes is a measure of the hepatic Iron burden, atomic absorption spectroscopy was applied to quantify liver ...
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Increases of intracellular magnesium promote glycodeoxycholate induced apoptosis in rat hepatocytes
... Retention of bile salts by the hepatocyte contributes to liver injury during cholestasis. Although cell injury can occur by one of two mechanisms, necrosis versus apoptosis, information is lacking regarding apoptosis as ...
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Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF-κB and the Mitochondrial Permeability Transition Pore
... primary rat hepatocytes, a bi- ologically relevant system that closely mimics normal hepato- cytes in the liver and is frequently used as a model for under- standing human hepatocyte physiology (7, 12, 22, ...
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Influence of Cl on organic anion transport in short term cultured rat hepatocytes and isolated perfused rat liver
... Transport of 35S-labeled sulfobromophthalein [35S]BSP was studied in short-term cultured rat hepatocytes incubated in bovine serum albumin. At 37 degrees C, initial uptake of [35S]BSP was 5-10-fold that at ...
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The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture
... of rat hepatocytes as an important pre- requisite for further experiments in which we would like to study potential hepatoprotective effect of various ...
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No evidence for protective erythropoietin alpha signalling in rat hepatocytes
... cultured hepatocytes and per- fused liver, reverse transcription into cDNA and real-time PCR were performed as described ...of rat EPO receptor sequence ...Cultured rat hepatocytes and UT-7 ...
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Metabolism of reverse triiodothyronine by isolated rat hepatocytes
... isolated rat hepatocytes was analyzed by Sephadex LH-20 chromatography, high performance liquid chromatography, and radioimmunoassay, with closely agreeing ...by rat hepatocytes is only ...
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Morphological, cytochemical and biochemical effects of Triton WR 1339 on rat hepatocytes
... Morphology and Cytochemistry Control Triton WR 1339 treatment Accumulation of Triton WR 1339 Clearance of Triton WR 1339 Comparison of catalase and aryl sulfatase distribution Biochemist[r] ...
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Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol
... Ethanol metabolism in hepatocytes is accompanied by release of a potent lipid chemoattractant for neutrophils. Production of the factor may initiate the inflammation associated with alcoholic hepatitis. In ...
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Rat hepatocytes exhibit basolateral Na+/HCO3 cotransport
... approximately 10-fold by 25 mM extracellular HCO3-.HCO3--stimulated Na+ uptake was saturable, abolished by 4-acetamido-4'-isothiocyano-2,2'-disulfonic acid stilbene (SITS), and unaffected by amiloride or Cl- removal. ...
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Insulin regulates apolipoprotein B turnover and phosphorylation in rat hepatocytes
... experiments in which hepatocytes were incubated with [32P]orthophosphate, insulin decreased 32P incorporation into apo B100 (42%) with only small effects on apo B48 (11%). The small insulin effect on apo B48 may ...
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Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes
... bioactivity of activin A into culture medium was detected after 48 h or later. Activity of activin A was released from parenchymal cells but not from nonparenchymal cells. mRNA for beta A subunit of activin was detected ...
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Cholecalciferol hydroxylation in rat hepatocytes under the influence of prednisolone
... in hepatocytes due to inhibiting vitamin D 3 25-hydroxylase ac- ...in hepatocytes contributed to a significant reduction in blood se- rum 25OHD 3 ...
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Role of insulin in lipoprotein secretion by cultured rat hepatocytes
... Control experiments, in which exogenous 125I-VLDL or endogenously labeled [14C]VLDL were added to cultures, revealed that the insulin-induced differences in VLDL accumulation and the lip[r] ...
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