Reactive gliosis
The Lentiviral Vector Pseudotyped by Modified Rabies Glycoprotein Does Not Cause Reactive Gliosis and Neurodegeneration in Rat Hippocampus
... Background: A human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector (LV) pseudotyped by a variant of rabies envelope glycoprotein, FUG-B2, has previously been prepared and used in transfection of ...
6
Reiser, Marianne (2019): Role of arylhydrocarbon receptor signalling in reactive gliosis. Dissertation, LMU München: Medizinische Fakultät
... Some of the differentially regulated proteins are quite interesting in context of reactive gliosis. Slc7a2 plays a role in the in classical or alternative activation of macrophages (Yeramian et al., 2006), ...
93
Microglia activation is essential for BMP7-mediated retinal reactive gliosis
... termed reactive gliosis. Reactive gliosis has been observed in all retinal disease and injury models includ- ing glaucoma, age-related macular degeneration, and diabetic retinopathy [6 – ...
18
Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury
... drive reactive gliosis, the large numbers of M2 macrophages also present will counteract this effect, both through decreasing astrocyte reactivity and through decreasing macrophage proliferation via ...
10
The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis
... and S100β represents astroglial activation and gliosis [41, 43]. In fact, under normal basal conditions, only subsets of intestinal enteric glia express GFAP, and most of the enteric glia cells coexpress S100β, ...
13
‘Reactive Gliosis’ in the Medulla Oblongata of Victims of the Sudden Infant Death Syndrome
... The present study discloses a significant increase in the number of reactive astrocytes in sections of the medulla oblongata in a group of SIDS victims in contrast to a group of control [r] ...
9
Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis
... intense reactive gliosis in all regions of the central nervous ...and reactive glial cells were observed in the brain samples of the control, sham, and CLP rats treated with IgG or IgGAM ...
12
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV
... the gliosis-affected brain ...mice gliosis was not accompan- ied by neuronal loss even at the late stage of the ...widespread reactive gliosis in the brain at this ...
14
Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion
... undergo reactive gliosis after acute injury or chronic neuronal stress [50, ...the reactive Müller cell gliosis measured by GFAP staining was significantly decreased with MMF treatment ...cell ...
12
Cerebral Outcomes in a Preterm Baboon Model of Early Versus Delayed Nasal Continuous Positive Airway Pressure
... esis is that hypoxia might inhibit the normal maturation of radial glia into astrocytes leading to their prolonged presence in the developing brain. Currently we are not able to distinguish between these possibilities in ...
16
PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation
... S100B ’ s deleterious effects in the central nervous system have been attributed to reactive gliosis (astrocytosis and microgliosis) [23,26,32,33]. The microglial marker Iba1 and astrocytic marker GFAP were ...
12
Astrocyte remodeling without gliosis precedes optic nerve axonopathy
... Such reactive gliosis contributes to remodeling within the optic nerve during glaucomatous progression, as in the DBA/2 J mouse model of hereditary glaucoma [3, 4, 22, 30, 43, ...
14
Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge
... We used the EVL method to establish a rat model of glaucoma. The glaucomatous eyes received an intravitreal injection of scrambled shRNA or cZNF609 shRNA. We employed immunofluorescence staining to determine the effect ...
8
Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia
... disease. Gliosis and neuronal dendritic injury have been well char- acterized in association with HAD in post-mortem studies and the present studies were undertaken to derive a human culture system in which to ...
9
Original Article Chronic anterior thalamic nucleus deep brain stimulation reduces gliosis and neuronal loss in hippocampal CA2 and CA3 regions of epileptic rhesus monkeys
... rant neurogenesis, gliosis and extended neuro- nal death are involved in epileptogenesis [11, 12]. Hippocampal specimens from TLE patients who underwent epilepsy surgery revealed the characteristic pattern of ...
12
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model
... in RGCs was observed as early as 1 day (G1d) after IOP elevation [16], but a significant increase of GFAP expres- sion was only observed on G1w in COH retinas [33], it is reasonable to assume that at a very early phase ...
15
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria
... Congestion of the brain and retinal vasculature has been documented in human cerebral malaria and is associated with poor prognoses in human cases of CM [41, 42]. Sev- eral factors are likely to contribute to congestion ...
17
MR imaging in patients with intractable complex partial epileptic seizures
... TABLE 1: Surgical Findings in 53 Patients with Intractable Complex Partial Seizures Finding Tumors Vascular malformations Pathologic changes of gliosis Total.. The resected tissue showed[r] ...
7
GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice
... The GPI-anchor is a complex structure for the attachment of proteins to the outer leaflet of the plasma membrane that involves more than 20 proteins in its production [5]. It bestows the capacity to localize in lipid ...
30
Contribution of Fetal MR Imaging in the Evaluation of Cerebral Ischemic Lesions
... F IG 3. MR imaging performed at 34 weeks’ gestation because of mild (12-mm) dilatation of the left lateral ventricle at US. T2-weighted axial section at the level of the vertex shows diffuse bilateral frontal ...
6