RECEPTOR ACTIVATOR
Identification of novel human receptor activator of nuclear factor kB isoforms generated through alternative splicing: implications in breast cancer cell survival and migration
... Additional file 7: A figure showing the flow cytometry viability assay and wound-healing assay for 293T and MDA-MB-231 cells after transfection with the indicated receptor activator of NF-kB (RANK) isoform. ...
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Interleukin 17A upregulates receptor activator of NF κB on osteoclast precursors
... and receptor activator for NF-κB ligand (RANKL) produced by osteoblasts ...decoy receptor for RANKL that inhibits osteoclast formation and bone resorption ...
11
Methotrexate and low dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor κβ expression in monocytes from patients with early rheumatoid arthritis
... Figure 4 Serum sRANKL and OPG levels in healthy donors and patients with RA at baseline and after MTX and low-dose prednisolone treatment. Both sRANKL and the sRANKL/OPG ratio increased in patients at baseline when ...
8
Inhibition of osteoclastogenesis by RNA interference targeting RANK
... TNF receptor-associated factors 6 (TRAF6), which leads to the activation of mitogen- activated kinases ...RANK receptor and starts the NF-κB pathway, which finally leads to activation of osteoclastogenesis ...
9
Effects of Pulsed Electromagnetic Fields of Different Frequencies on the Gene Expression of RANK and NFATc1 in Rat Osteoclasts Co Cultured with Osteoblasts
... The receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) play important roles and have been considered as indispensable for differentiation and ...
11
Multiple myeloma/hypercalcemia
... Multiple myeloma, a cancer of plasma cells, is associated with excessive tumor-induced, osteoclast-mediated bone destruction. Hypercalcemia remains the most frequent metabolic complication of myeloma in patients, and ...
6
Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits
... osteoprotegerin/ receptor activator of nuclear factor-κ B/RANK ligand (OPG/RANK/RANKL) has been described as critical in controlling osteoclast ...decoy receptor for ...
12
Cystatin C as a potential predictor of osteoprotegerin levels in healthy men, a cross sectional, observational study
... soluble receptor activator of nuclear factor κ B ligand (sRANKL) levels in a randomly selected male cohort over 50 years of age and its association with cystatin C, a cysteine proteinase inhibitor that ...
7
Role of C reactive protein in osteoclastogenesis in rheumatoid arthritis
... calcitonin receptor; DC-STAMP: dendritic cell-specific transmembrane protein; ELISA: enzyme-linked immunosorbent assay; ESR: erythrocyte sedimentation rate; FBS: fetal bovine serum; Fc γ R: Fcgamma receptors; ...
12
Case Report Mammary carcinoma with osteoclast-like giant cells: a case report
... [9]. Receptor activator of nuclear- (RANK), RANK ligand (RANKL), and matrix me- talloproteinase 1 (MMP1) are absent or not overexpressed in the current ...
6
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti TNFα or anti IL 1 therapies
... by receptor activator of NF-κB ligand (RANKL), also known as osteoclast differentiation factor (ODF), osteoprotegerin (OPG) ligand (OPGL), and TNF-related activation-induced cytokine ...
15
Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor positive/node negative/younger breast cancer patients
... growth receptor (HER)-2, which is over-expressed in about 25% of breast cancers and is associated with a more aggres- sive disease and a poorer outcome, has also been used as a prognostic and predictive marker ...
15
Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... PP was first described in chickens by Kimmel (Kimmel et al., 1968) and later isolated from other mammalian species by Chance et al. (Lin and Chance, 1974). Later, it was discovered by Larsson to be released by cells in ...
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Protein kinase C dependent activation of cytosolic phospholipase A2 and mitogen activated protein kinase by alpha 1 adrenergic receptors in Madin Darby canine kidney cells
... occurred in MDCK-D1 cells secondary to activation of MAP kinase, as has been observed in in vitro experiments using re- combinant enzyme (12, 13). We first examined whether this re- ceptor could cause phosphorylation and ...
10
Soluble urokinase plasminogen activator receptor (suPAR) and natural phosphorylcholine IgM antibodies in patients at clinical onset of diabetes mellitus
... nogen activator receptor (suPAR) and natural IgM antibodies directed against phosphorylcho- line (αPC-IgM) in Swedish diabetic patients (n = 164) and in healthy control subjects (n = ...
8
Design, Synthesis and Conformational Analyses of Bifacial Benzamide Based Foldamers
... co-activator sequence. The match was assessed on the basis of the RM“D -carbons on the helix and oxygen atoms on the foldamer together with an evlauation on the quality of orientation with respect to the helical ...
7
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain
... EphB receptor involved in both neuropathic pain and morphine tolerance dependence using EphB1 knockout mice ...blocking receptor bodies may not completely inhibit ...
13
A ligand free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer
... We have identified a soluble form of the human urokinase plasminogen activator (uPA) receptor (uPAR) in the ascitic fluids from patients with ovarian cancer. After purification of uPAR from the ascitic ...
9
Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells
... cell receptor (TCR) activity is impaired by transcriptional downregu- lation of CD247 (CD3 , the signaling domain of the TCR) and endocytosis of the TCR complex mediated by the viral protein U24 (17, ...the ...
10
Levels of Rankl and OPG In Gingival Crevicular Fluid during Orthodontic Tooth Movement
... A dynamic interaction also exists between the immune system and bone. Aaron and Choi 1 coined the term ―osteoimmunology‖ and highlighted the interdigitate communication between the immune and skeletal systems especially ...
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