Receptor, B1
Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis
... bradykinin receptor B1 (BKB1) and bradykinin receptor B2 ...a receptor implicated in articular nociception [18,19] and pro-inflammatory reactions ...
11
Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles
... scavenger receptor class B type I (SR-B1) was overexpressed in all investigated NPC cell lines and 75% of NPC biopsies, demonstrating that SR-B1 is a potential biomarker of ...
10
Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... SR- B1 acts in a peroxisome proliferator-activated receptor gamma (PPARγ)-dependent manner, which coincides with other research regarding PPAR’s role in the regula- tion of lipid metabolism and insulin ...
10
Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.
... Receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. Cell surface molecules that participate in this process are the primary determinants of ...
5
Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice
... mouse brain. Vascular (arrowheads), but not neuronal (arrows), lipoprotein receptor-related protein 1 (LRP-1) immunolabeling (left) was altered by genotype and/or treatment. LRP-1 immunostaining associated to ...
18
Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat
... expressed in central and peripheral tissues and is acti- vated by bradykinin (BK) and Lys-BK. Their metabolites, des-Arg 9 -BK and Lys-des-Arg 9 -BK, are the preferential agonists of B1R [15,16]. The latter is virtually ...
10
The B1 agonist [des Arg10] kallidin activates transcription factor NF kappaB and induces homologous upregulation of the bradykinin B1 receptor in cultured human lung fibroblasts
... is activated by phosphorylation and subsequent degradation of I k B which is an inhibitory protein that retains NF- k B in its in- active form in the cytosol. Upon dissociation of I k B, NF- k B translocates to the ...
13
Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia
... transient receptor potential vanilloid subtype 1 (TRPV1) is known as a non-selective cationic channel expressed in primary sensory C-fibers [16] and microglia ...
17
JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites
... two types of neuron have begun to reveal cellular processes and molecular mechanisms underlying axon/dendrite pruning. At the cellular level, both axon and dendrite pruning follow a similar series of cellular events, ...
10
The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer
... Lamin B1 is encoded by the gene LMNB1, which localizes to chromosome ...lamin B1 has been implicated in the pathogenesis of adult-onset autosomal dominant leukodystrophy, which resembles multiple sclerosis ...
17
Pharmacological analysis and structure determination of 7 methylcyanopindolol–bound b1 adrenergic receptor
... expression level 466 fmol/mg protein; (Baker et al., 2003)). Both of these cell lines also contained the stably transfected reporter gene CRE-SPAP. Negative control cells were parental CHO cells (CHO-CRE-SPAP cells), ...
46
Cloning and regulation of the rat bradykinin B1 receptor gene
... BKBi receptor has provided information on the elements ultimately responsible for the increase in expression with different inducing ...BKB] receptor mRNA levels have shown that new protein synthesis is not ...
262
A role for juvenile hormone in the prepupal development of Drosophila melanogaster
... Brains and other tissues were dissected and fixed in 3.9% formaldehyde (Fisher Scientific, Fairlawn, NJ, USA) in phosphate-buffered saline (PBS; Mediatech, Manassas, VA, USA) for 30 minutes, then rinsed and incubated in ...
10
Genomic instability in the type II TGF beta1 receptor gene in atherosclerotic and restenotic vascular cells
... II receptor within cells composing the atherosclerotic lesion might provide new theoretical and experimental avenues for understanding cardiovascular disease ...
8
Immune checkpoint inhibitor treatment in patients with oncogene-addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion
... factor receptor (EGFR) or v-Raf murine sarcoma viral oncogene homologue B1 (BRAF) mutation or an anaplastic lymphoma kinase (ALK) or ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) gene ...
12
Devigny, Christian (2012): Biomimetic screening of class B G protein-coupled receptors: design of tailored ligands for the Corticotropin-Releasing-Hormone receptor. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Structure of the N-terminal domain of a type [r] ...
189
A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis
... of receptor tyrosine kinases (RTK) by K252a or by the selective Met inhibitor PHA665752 does not affect Sema4d-induced inhibition of ureteric branching in metanephroi cultured at ...
11
Characterisation of a novel bacteriophage, 0BHG1 : and its interactions with its host "Rhodopseudomonas blastica"
... fractions B1 and B 2 ...fraction B1 contained two dominant proteins of Mr 14,500 and ...phage receptor and is required to inactivate 0BHG1 in ...
263
Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects
... Since pain is a complex bio-psychosocial phenomenon, the task of searching for and finding single gene varia- tions to explain individual differences could be seen as futile. However, in this study, the focus is on three ...
11
Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
... kinin B1 receptor; B2R: kinin B2 receptor; Danshen: salvia miltiorrhiza; DM: diabetes mellitus; ± dp/dt: maximum speed of contraction/relaxation; GSK-3 β : glycogen synthase kinase 3 β ; IL-6: ...
8