Receptor binding domain (RBD)
Substitutions in the Receptor-Binding Domain of the Avian Sarcoma and Leukosis Virus Envelope Uncouple Receptor-Triggered Structural Rearrangements in the Surface and Transmembrane Subunits
... the receptor-binding domain (RBD) within EnvA. Receptor spec- ificity maps to two small, highly variable domains, hr1 and hr2, within the SU subunit (4, 5, 14, ...hr2 domain of ...
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Intrahost variations in the envelope receptor binding domain (RBD) of HTLV 1 and STLV 1 primary isolates
... Four primate (PTLV), human (HTLV) and simian (STLV) T-cell leukemia virus types, have been characterized thus far, with evidence of a simian zoonotic origin for HTLV-1, HTLV-2 and HTLV- 3 in Africa. The PTLV envelope ...
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A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein
... the receptor-binding domain (RBD) of the MERS-CoV spike protein and thereby competitively blocks the binding of the RBD to its cellular receptor, dipeptidyl peptidase 4 ...
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Potential for Developing a SARS-CoV Receptor Binding Domain (RBD) Recombinant Protein as a Heterologous Human Vaccine against Coronavirus Infectious Disease (COVID)-19
... SARS-CoV receptor-binding domain (RBD) recombinant protein was developed and manufactured under current good manufacturing practices in ...SARS-CoV RBD and that neutralize the SARS-CoV ...
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Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus
... the receptor-binding domain (RBD) from the MERS-CoV spike protein and determined its crystal ...MERS-CoV RBD with other coronavirus RBDs, successfully positioning MERS-CoV on the ...
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Receptor-binding domain of murine leukemia virus envelope glycoproteins.
... the binding of P or X envelope glycoproteins to their receptors has been previously suggested (1, ...the receptor, or alternatively, it may have an indirect effect by inducing appropriate folding of the ...
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Characterization of the Prototype Foamy Virus Envelope Glycoprotein Receptor-Binding Domain
... Env receptor- binding ...cellular receptor molecules for FVs have eluded ...Env RBD nor the contribution of glycosylation to receptor binding, which is dif- ferent in insect ...
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Identification of 22 N-glycosites on Spike Glycoprotein of SARS-CoV-2 and Accessible Surface Glycopeptide Motifs: Implications on Vaccination and Antibody Therapeutics
... N-terminal domain (NTD), 2 are located in receptor-binding domain (RBD), 3 are located in the rest of S1 ...(FP) domain is neighbored by N-glyco-site N657. In contrast, the ...
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Activation of a Cell Entry Pathway Common to Type C Mammalian Retroviruses by Soluble Envelope Fragments
... on receptor recognition and virus binding, but they abrogate fusion triggering in both cell-cell and virus-cell fusion assays (1, ...the receptor-binding domain (RBD) of the SU ...
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Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection
... the binding affinity of several natural products on SARS-CoV-2 marker protein, RBD-S, PD-ACE2, and SARS-cov-2 ...of binding interaction was performed using MOE 2010 (Licensed from Faculty of Pharmacy ...
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GRB2 Interaction with the Ecotropic Murine Leukemia Virus Receptor, mCAT-1, Controls Virus Entry and Is Stimulated by Virus Binding
... transferrin receptor (TfnR) (fifth and sixth panels) ...transferrin receptor (bottom left) were normalized to total mCAT-1 or trans- ferrin receptor levels in cell lysates for nontargeting and ...
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The Hypervariable Domain of the Murine Leukemia Virus Surface Protein Tolerates Large Insertions and Deletions, Enabling Development of a Retroviral Particle Display System
... hypervariable domain linking the N-terminal receptor-binding domain and the highly conserved C-terminal domain of MuLV SUs was further in- vestigated by constructing a series of small ...
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Genetic Uniformity of a Specific Region in SARS-CoV-2 Genome and In-Silico Target-Oriented Repurposing of N- Acetyl-D- Glucosamine
... spike receptor-binding domain bound with ACE2 (6M0J) and RNA-binding domain of nucleocapsid phosphoprotein (6WKP) with our ligand ...
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While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?
... the receptor binding domain of lineage B (beta)-CoVs can be divided into functionally distinct ...entry receptor specific for clade 1 of such ...unknown receptor in human cells (Letko ...
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Characterization of sugar binding by the mannose receptor family member, Endo180.
... Soluble Endo180 constructs were generated as chimeric proteins fused to the Fc portion of human Ig. The presence of the Fc tail enables detection using anti-human Fc antibodies and, if required, purification of ...
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The receptors for gibbon ape leukemia virus and amphotropic murine leukemia virus are not downregulated in productively infected cells
... GALV particles efficiently attach to infected cell surface Previously, it has been reported that MLV viruses can nonspecifically bind to target cells and the binding is receptor-independent [19-21]. ...
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Devigny, Christian (2012): Biomimetic screening of class B G protein-coupled receptors: design of tailored ligands for the Corticotropin-Releasing-Hormone receptor. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Structure of the N-terminal domain of a type [r] ...
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The inflammasome in leprosy skin lesions: an immunohistochemical evaluation
... Initially, tissue samples were dewaxed in xylene and dehy- drated in ethyl alcohol. Then, endogenous peroxidases were blocked with 3% H 2 O 2 for 45 minutes. Antigen retrieval was performed in citrate buffer, pH 6, at ...
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Progesterone receptors animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer
... androgen receptor and the PR in mammalian transfec- tion assays ...steroid receptor activity by promot- ing the termination of receptor-mediated gene transcrip- tion rather than by interfering with ...
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Rational ligand based drug design and structure activity relationship studies in the ligand binding domain of the glucocorticoid receptor ?
... for binding GR resulted in a pharmacophore-guided SAR moving in two distinct ...GR binding affinity and trans-repression activity’, making GR LBVS approaches especially challenging [65] ...
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