Receptor, Drug
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor
... of drug-metabolizing enzymes and transporters, due not only to autoinduction by itself or induction by other drugs and foodstuffs, but also its broad effects on drug-drug ...X receptor (PXR) ...
11
Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor
... the drug or signaling molecule has been the approach of the pharmaceutical industry, producing a multitude of structure-activity relationships of considerable ...the receptor and use functional assays to ...
172
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug induced osteomalacia
... D receptor (VDR), and it is expressed mainly in the kidney, where VDR is also ...xenobiotic receptor (SXR) also enhances the expression of CYP24, providing a new molecular mechanism of drug- induced ...
11
HISTAMINE SUBTYPE 3 RECEPTOR ANTAGONISTS: CURRENT STATUS WITH FUTURE PROSPECTS IN DRUG DISCOVERY AND DRUG DEVELOPMENT
... H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic ...histamine receptor was discovered in ...
8
Probing the Roles of Receptor Structure, Drug Receptor Interactions, and Receptor Crosstalk in Ligand Gated Ion Channel Function
... Stage V–VI Xenopus laevis oocytes were employed. For wild-type receptor and receptors containing conventional mutations, quantified mRNA of all subunits were mixed in a ratio of α : β : γ : δ = 2:1:1:1 by mass. If ...
220
Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach
... The spike protein showed no significant matches with human protein by blast search. conservation analysis of spike protein through blastp search against viral genome showed Severe acute respiratory syndrome-related ...
16
Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors
... folate receptor-mediated active targeting drug delivery with the stable drug delivery during circulation endowed by the core cross-linking, showed the highest (at all the time points) and the longest ...
12
HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer
... estrogen receptor; ESR1: estrogen receptor 1; FDA: Food and Drug Administration; FFPE: formalin-fixed paraffin-embedded; GOI: genes of interest; HER2: human epidermal growth factor receptor 2; ...
12
HOMOLOGY MODELING AND DOCKING STUDIES ON HIV REVERSE TRANSRIPTASE INHIBITORS
... 1. Scoring function 11 : Scoring functions are fast approximate mathematical methods used to predict the strength of the non-covalent interaction between two molecules after they have been docked. Most commonly one of ...
20
In Silico Analysis on Docking Studies of Haemolysin Protein in Vibrio Paraheamolyticus
... studies were done for 10 compounds receptor. Molecular dynamics and simulation is analysed for two natural compounds (Cyanidin) and (Bergapten). During the simulation studies, these 2 compounds was shown better ...
8
Effects of telmisartan on weight gain and obesity in patients with essential hypertension and metabolic syndrome
... the drug which belongs to the group of angiotensin receptor blockers, the statistical values both systolic and diastolic blood pressure, random blood sugar, body weight, BMI and waist circumference are ...
5
Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors
... overcome drug resistance of HNSCC and to reduce non-specific toxicity of anti-tumor drug we applied active and HNSCC cell-specific delivery of encapsulated doxorubicin (Doxil) into the cytoplasm of HNSCC ...
12
Vesicular drug delivery against leishmaniasis in animals: a critical evaluation
... free drug probably due to the covalent link through an ether bond (Prajapati et ...low-cost drug cargo, chemically stable inorganic minerals but also degraded nontoxic product when metabolized (Kester et ...
11
Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast
... estrogen receptor modulator (SERM), or estrogen receptor agonist/antagonist, that was recently approved by the US Food and Drug Administration for the treatment of dyspareunia associated with vulvar ...
7
“Technologies for the Improvement of Buccal Drug Delivery System” by Sagar, India.
... based drug delivery vectors is an developing tool for the transport of substances to and fro across the BBB and one may analyze receptor-mediated transcytosis, adsorptive-mediated transcytosis, and the ...
8
Synthesis of 1-Aryloxy-2-hydroxy-3-substituted Aminocyclohexane and its Analogues for Possible Antimalarial Activity
... antiparasitic drug discovery differs in many ways from drug discovery for the chronic conditions that have become a primary focus of the pharmaceutical industry ...effective drug as antimalarials, we ...
9
Reversal Effect of Intra-Central Amygdala Microinjection of L-Arginine on Place Aversion Induced by Naloxone in Morphine Conditioned Rats
... type receptor signalling in producing of the associated learned behavior, the ineffective dose effect of the opioid was challenged by pairing the drug response testing with a single injection of a low dose ...
8
The Effects of Telmisartan to Thickness of Aortic Tunica Media in 8% Sodium Chloride-Induced Wistar Rats (Rattus Norvegicus)
... proliferator-activated receptor gamma (PPARã). Telmisartan is antihypertensive drug that not only blocks angiotensin receptor but also leads to the decrease of blood pressure, activates peroxisome ...
7
Study on Drug Utilization Pattern of Anti-hypertensives at a Tertiary Care Teaching Hospital
... angiotensin receptor blockers and β-blockers are useful in those suffering from heart ...single drug does not adequately control blood pressure, drugs with different modes of action can be combined to ...
65
Photothermal ablation of inflammatory breast cancer tumor emboli using plasmonic gold nanostars
... of receptor status or drug resistance and that these nanoparticles penetrate the tumor embolic core in 3D culture, allowing effective photothermal ablation of the IBC tumor ...
14