Receptor modulator
Effects of multiple-dose ponesimod, a selective S1P<sub>1</sub> receptor modulator, on lymphocyte subsets in healthy humans
... population with low numbers in peripheral blood, rendering their analysis difficult, the data in this study support previ- ous observations in animal studies that absolute numbers or tissue distribution of NKT cells are ...
9
Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats
... Bazedoxifene (BZA), a selective estrogen receptor modulator (SERM), is used to prevent postmenopausal osteoporosis. It has fewer estrogenic side effects than conjugated estrogen. SERM is a ligand of ER α ...
8
Analytical Review on Raloxifene -An Estrogen Receptor Modulator in Different Pharmaceutical Formulations and Biological Fluids
... Raloxifene (RLX) is an oral selective estrogen receptor modulator (SERM). It is showing estrogenic action on bone and anti-estrongenic action on uterus and breast.RLX is chemically[6- ...
17
Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
... androgen receptor (AR), a member of the nuclear receptor super-family ...in receptor function lead to multiple disorders such as hypogonadism, muscle wasting, cachexia, osteoporosis, loss of ...
12
Rational design of a novel AMPA receptor modulator through a hybridization approach
... GluA2 receptor an appropriate spacer must be incorporated into the hy- bridized compounds ...flop receptor isoforms, showing encourag- ing levels of efficacy as an AMPA receptor modulator and ...
7
Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations
... that another mechanism is responsible for PR-B loss. E2 is the main regulator of transcription of both PR isoforms, and may also contribute to the silencing of PR-B by selective methylation of the promoter under certain ...
14
Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus
... the receptor and therefore detects also the GH-binding pro- tein in ...GH receptor mRNA was measured, it means in fact a combination of the mRNAs for the GH receptor and the GH binding protein was ...
8
Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene
... estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissue- specific ...estrogen ...
11
Selective estrogen receptor modulator: efficacy in abnormal uterine bleeding in perimenopausal women
... April 2019 Volume 8 Issue 4 Page 1495 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Mani A et al Int J Reprod Contracept Obstet Gynecol 2019 Apr;8(4) 1495 1499 www ij[.] ...
5
Improved process for Centchroman, a selective estrogen receptor modulator (SERM)
... The aq phase was extracted with ethyl acetate 2X250 mL, and the combined organic extracts were washed with brine solution 500 mL, and organic phase was dried over Na2SO4 and concentrated[r] ...
6
A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth
... In surmary, this report showed that non-toxic selective AhR modulator DIM inhibited the proliferation of human gastric cancer cell line SGC7901 in vitro by inducing cell apoptosis and ar[r] ...
9
Fbxo22 mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer
... estrogen receptor a (ER) and coactivator dynamics and growth factor signaling, the molecular basis of these mechanisms is still ...steroid receptor coactivator (SRC) from ...factor receptor type ...
18
Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control
... Free fatty acids (FFAs) are essential nutrients but have also been implicated in disease processes, including renal disease (1) and especially diabetic nephropathy (2). It is now recognized that FFAs can activate a ...
13
Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast
... estrogen receptor modulator (SERM), or estrogen receptor agonist/antagonist, that was recently approved by the US Food and Drug Administration for the treatment of dyspareunia associated with vulvar ...
7
ALZHEIMER’S DISEASE: A REVIEW
... hormone treatments for the prevention of dementia. Additionally, no benefit has been found in the treatment of AD with estrogen. Research work shows that postmenopausal hormone therapy increases the risk of dementia in ...
9
Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory
... 46. Nickelsen T, Lufkin EG, Riggs BL, Cox DA, Crook TH. Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in postmenopausal ...
8
Clinical update on the use of ospemifene in the treatment of severe symptomatic vulvar and vaginal atrophy
... Abstract: The physiological decrease in vaginal estrogens is accountable for the emergence of vulvar and vaginal atrophy (VVA) and its related symptoms such as vaginal dryness, dyspareunia, vaginal and/or vulvar ...
10
Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
... estrogen receptor; FACS: fluorescence-activated cell sorting; H&E: hematoxylin and eosin; HRT: hormone replacement therapy; IL: interleukin; ip: intraperitoneal; OVX: ovariectomy; PBS: phosphate buffered ...
11
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer
... The androgen receptor (AR) is a driver of prostate cancer (PCa) cell growth and disease progression. Therapies for advanced PCa exploit AR dependence by blocking the production or action of androgens, but these ...
14
Processing of ultra short optical pulses for high bit rate optical communications
... the modulator is considered (top row of ...the modulator bias voltage was then carried out to slightly degradate the extinction ratio of the signal (bottom row of ...the modulator parameters, the ...
178