Receptor tyrosine kinase pathways
Receptor tyrosine kinase signaling pathways: a review
... these pathways in cancer cells by mutation, amplification/deletion, chromosomal translocation, over expression, or epigenetic silencing lead to constitutive activation or suppression of ...the receptor ...
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Real time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist receptor complexes
... specific tyrosine residues of the receptor dimer resulting in the activation of different intra- cellular signalling cascades ...signalling pathways are relatively well understood with ...
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AXL receptor tyrosine kinase as a therapeutic target in NSCLC
... While we eagerly await the early-phase results of AXL- specific inhibitors in NSCLC patients, ongoing clinical trials in lung cancer continue to utilize broad-spectrum multikinase inhibitors that target various oncogenic ...
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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells
... factor receptor (EGFR) that causes a constitutive activation of the EGFR signaling pathway and thus provides tumor cells with an increased abnormal growth ...EGFR tyrosine kinase inhibitors (TKIs) ...
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Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
... The ErbB family of receptors are outstanding targets for breast cancer therapies (and diagnosis). Optimal clinical performance of ErbB-targeted reagents will best be achieved by harnessing knowledge about the biologic ...
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Application of computational approaches to study signalling networks of nuclear and Tyrosine kinase receptors
... Receptor tyrosine kinases (RTKs) transmit their activa- tion signal across the plasma membrane, and many stu- dies have demonstrated that the receptors, and not the growth factors, mediate the pleiotropic ...
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MERTK receptor tyrosine kinase is a therapeutic target in melanoma
... proto-oncogene tyrosine kinase (MERTK) is a receptor tyrosine kinase with oncogenic properties that is often overexpressed or acti- vated in various ...signaling pathways includ- ...
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PEAK1, a Novel Kinase Target in the Fight Against Cancer
... induced tyrosine phosphorylation of PEAK1 ...its tyrosine kinase ...Raf-Erk pathways downstream of integrins and receptor tyrosine kinases (RTKs) point to a central role for this ...
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Distinct expression and prognostic value of members of the epidermal growth factor receptor family in ovarian cancer
... factor receptor (EGFR) tyrosine kinase family consists of four members: EGFR, ERBB2, ERBB3, and ...triggers receptor homodimerization or heterodimerization, resulting in the activation of ...
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Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma
... several pathways could be a more effective strategy for treating ...factor receptor (EGFR)-tyrosine kinase inhibitor (gefitinib) or a multi-targeted kinase inhibitor (sorafenib) in ...
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Productive Interaction between Transmembrane Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor β Receptor
... of tyrosine phosphorylation of the precursor form of the PDGF  receptor (1, ...caused tyrosine phos- phorylation of the mature form only (7, ... receptor was immunoprecipitated by our ...
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Paradoxes of the EphB1 receptor in malignant brain tumors
... releases tyrosine phosphatases and ubiq- uitin ligase Cbl to degrade EphB1 ...the receptor proteins, resulting in termination of Eph/ephrin signaling ...
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In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features
... the receptor dimerization is induced and intracellular protein TK is activated with subsequent initiation of numer- ous downstream signaling events, which ultimately leads to cell proliferation, migration, and ...
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Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
... VEGFR, PDGFR, and c-Kit Many RTK inhibitors have more than one target. Sunitinib malate (Pfizer; sunitinib in following), a small molecule inhibitor, targets vascular endothelial growth factor receptor (VEGFR), ...
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Holtermann, Nadine (2016): Effektivität und Toxizität von Tyrosinkinase-Inhibitoren beim felinen Injektionsstellen-assoziierten Sarkom und caninen epitheliotropen Lymphom. Dissertation, LMU München: Tierärztliche Fakultät
... Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-. 1) in pathological angiogenesis[r] ...
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Cell Signalling in Limb Development and Hindbrain Segmentation
... the kinase region of the insulin receptor under relaxed conditions and this led to the identification of a new human (EEK, ERK) as well as a new rat member of the Eph family (Chan & Watt, ...the ...
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Mechanism of insulin receptor kinase inhibition in non insulin dependent diabetes mellitus patients Phosphorylation of serine 1327 or threonine 1348 is unaltered
... of receptor serine/threonine residues has been proposed to exert an inhibitory influence on receptor tyrosine kinase activity and Ser 1327 and Thr 1348 have been identified as specific sites ...
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Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University
... This results in the activation of the receptors kinase domain leading to cross-phosphorylation of tyrosine residues on the intracellular domain of the receptor providing a start for the [r] ...
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Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy
... Fms-like tyrosine kinase-3 (FLT3; fetal liver kinase-2; human stem cell tyrosine kinase-1; CD135) is a class III receptor tyrosine kinase that is normally involved ...
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Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity.
... In order to address this question, kinase-defective mutants of two previously described The avian c-erbBl gene encodes a transmembrane growth factor receptor with tyrosine kinase activit[r] ...
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