Recombinant BCG
Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model
... Recombinant BCG technology has allowed the construc- tion of immunotherapeutic agents aimed at specific tar- ...the BCG-induced immune response that is directly related to the antitumor effect, ...
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Apoptosis Activity of the Mouse Macrophage Cell Line J774A.1 Infected with a Recombinant BCG consisting the C-Terminus of Merozoite Surface Protein-1 of Plasmodium falciparum
... a recombinant BCG clone expressing the C-terminus of merozoite surface protein-1 (BCG-MSP1C) of Plasmodium falciparum for 48 ...parent BCG cells was used as a ...the BCG-MSP1C cells was ...
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Safety and Immunogenicity of Novel Recombinant BCG and Modified Vaccinia Virus Ankara Vaccines in Neonate Rhesus Macaques
... the BCG delivery to 10 weeks of age benefits the quantity and quality of BCG-induced CD4 T-cell responses ...(20). BCG and related mycobacterial vectors have been explored as vaccines against other ...
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A novel method for monitoring Mycobacterium bovis BCG trafficking with recombinant BCG expressing green fluorescent protein.
... intravesical BCG- treated patients were also identified by electron microscopic observation ...(FITC)-labeled BCG, the ability of T-24 cells to take up the pathogen was also observed ...monitoring ...
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Role for Gr-1+ Cells in the Control of High-Dose Mycobacterium bovis Recombinant BCG
... high-dose BCG. Instead, experiments determining the clearance of BCG have been done using lower doses of the vaccine, primarily in an effort to model the pathogenic transmission of Mycobacterium ...
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Recombinant BCG expressing LTAK63 adjuvant induces superior protection against Mycobacterium tuberculosis
... type BCG, (2) the histopathological analyses of the lungs after the challenge, which show preserved tissue even after a very high challenge dose and (3) although the intratracheal challenge doses used are much ...
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Efficiency of Recombinant Bacille Calmette Guérin in Inducing Humoral and Cell Mediated Immunities against Human Immunodeficiency Virus Type 1 Third Variable Domain in Immunized Mice
... of recombinant BCG (rBCG- mV3) designed to express trimeric HIV-1 V3 loop (mV3) in rBCG-mV3-immu- nized ...a BCG-expression vector, and then rBCG-mV3 was constructed by in- troducing the ...
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Inhibition of the Multiplication of Mycobacterium leprae by Vaccination with a Recombinant M. bovis BCG Strain That Secretes Major Membrane Protein II in Mice
... The BCG vaccine has been used for the prevention of tu- berculosis, although its role in the prevention of leprosy is still being ...of BCG against leprosy has been tested in several trials, including ...
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Mycobacterium bovis BCG as a Delivery System for the dtb Gene Antigen from Diphtheria Toxin
... of BCG which is used in Brazil as a live vaccine against human tuberculosis was genetically modified to carry and express the gene encoding for the diphtheria toxin fragment B ...into BCG cells by ...
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Repeated inoculations of Mycobacterium bovis Bacille Calmette Guérin (BCG) are needed to induce a strong humoral immune response against antigens expressed by the bacteria
... [21]. BCG is an intracellular bacte- rium that resides within mononuclear phagocytes and preferentially induces a cellular immune response ...by BCG has been ...the BCG growth conditions [15] and ...
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Cellular Immune Responses to Recombinant Mycobacterium bovis BCG Constructs Expressing Major Antigens of Region of Difference 1 of Mycobacterium tuberculosis
... bovis BCG is also the most controversial vaccine in current ...current BCG vaccine might be to produce recombinant BCG strains that express major antigens encoded by genes that are present in ...
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Recombinant Mycobacterium bovis BCG Expressing the Chimeric Protein of Antigen 85B and ESAT-6 Enhances the Th1 Cell-Mediated Response
... of BCG could be to construct a recombinant BCG (rBCG) which either overexpresses immunogenic antigens or modulates the ensuing immune response ...standard BCG strains ...
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Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors
... of recombinant BCG strains possessing consistent insert expression has encountered challenges in ...large recombinant BCG accession lots which stably express the lentiviral antigens, human ...
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CLONING AND EXPRESSION OF MALARIA AND TUBERCULOSIS EPITOPES IN MYCOBACTERIUM BOVIS BACILLE CALMETTE GURIN
... A recombinant BCG containing a synthetic gene coding for the malarial epitopes namely, the fragment 2 of region II of EBA-175 (F2R(II)EBA) and the repeat sequence of the circumsporozoite protein NANP ...
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A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.
... SIV challenge of monkeys with a high-frequency single- epitope SIV Gag-specific CTL response. Western blot analysis detected weak reactivity to SIV p27 and the Gag precursor in the serum of only one of the vaccinated ...
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Robust Immunity to an Auxotrophic Mycobacterium bovis BCG-VLP Prime-Boost HIV Vaccine Candidate in a Nonhuman Primate Model
... a recombinant BCG (rBCG) ex- pressing HIV-1 subtype C Gag is able to prime the immune system of chacma baboons for a boost with HIV-1 Pr55 gag virus-like par- ticles (Gag VLPs), resulting in induction of ...
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Markedly impaired bilateral coordination of gait in post-stroke patients: Is this deficit distinct from asymmetry? A cohort study
... and BCG in patients with and without walking aids, to monitor potential changes in GA and BCG over time during the rehabilitation process until the moment the patients have apparently reached a plateau in ...
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Differential Live Mycobacterium tuberculosis-, M. bovis BCG-, Recombinant ESAT6-, and Culture Filtrate Protein 10-Induced Immunity in Tuberculosis
... bovis BCG strain, are processed along the endosomal pathway, ac- tivating stronger responses of proinflammatory cytokines, such as TNF- ␣ , IL-2, and IL-6, than the responses activated by virulent mycobacteria ...
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The association between Bacillus Calmette Guérin vaccination (1331 SSI) skin reaction and subsequent scar development in infants
... after BCG vaccination has been used as one of the indicators for successful vaccin- ation and in estimating vaccine coverage ...Since BCG is administered throughout the world as the only licensed preventive ...
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Comparative study of BCG vs BCG + Interferon Combination as Intravesical Therapy in Superficial Bladder Cancer.
... BCG is currently the most effective intravesical agent for the treatment and prophylaxis of superficial bladder ...cancer. BCG is recognized as a nonspecific immune stimulant. Intravesical BCG ...
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