Recombinant Granulocyte Colony-Stimulating Factor
A Randomized, Double-Masked, Placebo-Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor Administration to Preterm Infants With the Clinical Diagnosis of Early-Onset Sepsis
... necrosis factor- ␣ , interleukin 6, granulocyte-macrophage colony stimulat- ing factor, and G-CSF, and blood leukocyte counts, ab- solute neutrophil counts, immature/total neutrophil ra- tios, ...
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Granulocyte Colony-Stimulating Factor Serum and Urine Concentrations in Neutropenic Neonates Before and After Intravenous Administration of Recombinant Granulocyte Colony-Stimulating Factor
... One aspect of our study, not previously encoun- tered in rG-CSF pharmacokinetic studies, was the extremely high pre-first-dose G-CSF serum and urine concentrations in our neutropenic neo[r] ...
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Recombinant Granulocyte Colony-Stimulating Factor Administered Enterally to Neonates Is Not Absorbed
... ABSTRACT. Granulocyte colony-stimulating factor (G-CSF) is present in liquids swallowed by the fetus and neonate; specifically, amniotic fluid, colostrum, and hu- man ...as stimulating ...
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Preliminary Report: rhG-CSF May Reduce the Incidence of Neonatal Sepsis in Prolonged Preeclampsia-associated Neutropenia
... To determine whether ad- junctive therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) could reverse the neutropenia and reduce the incidence of sepsis ( < 2[r] ...
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Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities
... human recombinant IL-3 and granulocyte- macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target ...multipotential ...
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Induction of Apoptosis on K562 Cell Line and Double Strand Breaks on Colon Cancer Cell Line Expressing High Affinity Receptor for Granulocyte Macrophage-Colony Stimulating factor (GM-CSF)
... Apoptosis. Comet assay and nuclear staining were used for assessment of the apoptotic effect of recombinant hybrid protein. In comet assay, apoptotic cells after treatment showed puffy tail and pin head while ...
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Cleaning validation of recombinant human granulocyte colony stimulating factor (rhu gcsf) in multi product manufacturing facility: a case study
... The equipments were rinsed with 150 ml of cooled WFI by covering the total surface of the equipment after completion of swab sampling. The rinsate were collected in depyrogenated glass bottles. The theoretical acceptance ...
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In vivo Characterization of Fusion Protein Comprising of A1 Subunit of Shiga Toxin and Human GM-CSF: Assessment of Its Immunogenicity and Toxicity
... to granulocyte-macrophage colony stimulating factor) is a recombinant toxin that targets the GM- CSF receptor that is present on acute myeloid leukemia cells ...using recombinant ...
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Human Granulocyte Colony-stimulating Factor May Improve Outcome Attributable to Neonatal Sepsis Complicated by Neutropenia
... Prophylactic or simultaneous administration of recombinant human granulocyte colony stimulating factor in the treatment of group B streptococcal sepsis in neonatal rats. Smith WS, Sumnic[r] ...
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Recombinant Human Granulocyte Colony-stimulating Factor Therapy for Sepsis in Infants With Neutropenia
... A randomized, placebo- controlled trial of granulocyte colony-stimulating factor administration to newborn infants with neutropenia and clinical signs of early-onset sepsis.. Lieschke GJ[r] ...
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Original Article Modulation of the function of dendritic cells in adolescents with chronic HBV infection by IFN-λ1
... with recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin-4 (rhIL-4) can induce the DCs maturation and promote the ...
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A Randomized Trial of Granulocyte-Macrophage Colony-Stimulating Factor in Neonates With Sepsis and Neutropenia
... human recombinant hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, and interleukin-3) ...
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Recombinant murine granulocyte macrophage colony stimulating factor has megakaryocyte colony stimulating activity and augments megakaryocyte colony stimulation by interleukin 3
... megakaryocyte colony formation. The dose-response curve for megakaryocyte colony induction with rGM-CSF showed plateau megakaryocyte stimulation at 9 ...megakaryocyte colony induction) was added to ...
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Recombinant Human Granulocyte Colony Stimulating Factor (Rh G-CSF) Administered Before, During and After High Dose Chemotherapy to Patients with Acute Myeloid Leukemia: Effect on Hematopoiesis and Bone Marrow Microenvironment
... CSFs: Colony Stimulating Factors; ILs: Interleukins; G-CSF: Granulocyte Colo- ny-Stimulating Factor; GM-CSF: Granu- locyte-Macrophage Colony Stimulating Factor; ...
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Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... murine colony-stimulating factors (CSF) recombinant interleukin 3 (IL-3), natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 ...
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Cloning and expression of recombinant human granulocyte-macrophage colony stimulating factor (rhGMCSF) in Escherichia coli
... The product obtained in this study was inclusion body that needed the stages of rinsing and solution. Inclusion body formation has some advantages like formation of more products because of low toxicity of inclusion body ...
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Different effects of granulocyte colony-stimulating factor and erythropoietin on erythropoiesis
... Anemia can develop from loss of RBCs, a reduction in RBC production, increased destruction of RBCs, or a shorter RBC lifespan. The World Health Organization de- fines anemia as a hemoglobin level lower than 12 g/dl in ...
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Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 cause basophil histamine release
... Histamine-releasing factors (HRFs) have been shown to be released from a variety of human cells, including T lymphocytes and alveolar macrophages. We considered the possibility that known cytokines might possess such ...
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Biology and Clinical Applications of Hemopoietins in Pediatric Practice
... Phase I/Il study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Gabrilove JL, Jakubowski A, Fain K, e[r] ...
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Increased granulocyte colony stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
... G-CSF administration to mice. Recombinant human G-CSF (Am- gen) was administered by daily subcutaneous injection at a dose of 10 m g/kg per day for 7 d. Peripheral blood was obtained before the first G-CSF dose ...
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