Recombinant Human Soluble Thrombomodulin
Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation and mortality: a retrospective cohort study
... day 7. In a phase III trial of rhTM for patients with DIC, Saito et al. showed that the rate of change in D-dimer levels in the rhTM group was significantly greater than that in the heparin group, suggesting that rhTM is ...
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Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
... Introduction Recombinant human soluble thrombomodulin (rhsTM) is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant ...
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Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial
... rhTM: Recombinant human soluble thrombomodulin; SP-D: Surfactant protein D; TAT: Thrombin – antithrombin complex; UIP: Usual interstitial pneumonia; UMIN-CTR: University Hospital Medical ...
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Benefit profile of recombinant human soluble thrombomodulin in sepsis induced disseminated intravascular coagulation: a multicenter propensity score analysis
... of recombinant human soluble thrombomodulin (rhTM) have been demonstrated, with promising evidence suggestive of efficacy for patients with severe sepsis involving coagulopathy in a phase IIb ...
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Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study
... Recombinant human soluble thrombomodulin (rhTM) is the only agent for the treatment of DIC [12]. rhTM was approved in 2008 and has been used clinically for DIC treatment in Japan. Several ...
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Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin
... 10. Vincent JL, Ramesh MK, Ernest D, Larosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi ...
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The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study
... Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent composed of the active, extracellular domain of thrombomodulin (TM) that reg- ulates the imbalanced ...
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Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
... [12]. Recombinant human soluble thrombomodulin (rhTM) binds to thrombin to inacti- vate coagulation, and the thrombin-rhTM complex acti- vates protein C to produce activated protein C (APC), ...
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The Concept Study of Recombinant Human Soluble Thrombomodulin in Patients with Acute Respiratory Distress Syndrome
... The modulation of the coagulation disturbance by our conventional therapy with rhTM administration may be related to the mortality of ARDS patients, because the serial changes in the fib[r] ...
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Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients
... Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and dissemi- nated intrav[r] ...
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Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan
... as recombinant human activated protein C, antithrombin, recombinant tissue factor pathway inhibitor, and recombinant human soluble thrombomodulin (rhTM), have already been ...
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Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro
... of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation ...(NETosis). Human peripheral ...
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Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments
... studies, antithrombin (AT) and recombinant human soluble thrombomodulin (rhTM) were frequently used for the treat- ment of sepsis-induced DIC in Japan (Table 1). However, the frequencies of ...
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Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
... TM: Thrombomodulin; APC: Activated protein C; rTM: Recombinant human soluble thrombomodulin; rhAPC: Recombinant human activated protein C; DIC: Disseminated intravascular ...
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Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation
... recombinant thrombomodulin. Regarding this study, one must keep in mind that not all patients had sepsis-associ- ated DIC and the greatest benefit from the treatment was seen in patients with at least one ...
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Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation
... Peripheral blood monocytes were derived from peripheral whole blood of healthy volunteers by Ficoll-Hypaque density centrifugation as described elsewhere [24]. Briefly, mononuclear cells were seeded at 5610 5 ...
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Impaired Flow-Mediated Vasodilation, Carotid Artery Intima-Media Thickening, and Elevated Endothelial Plasma Markers in Obese Children: The Impact of Cardiovascular Risk Factors
... Germany). Soluble thrombomodulin was assayed using a sandwich enzyme immunoassay (Diagnostica Stago, Asnieres-Sur-Seine, ...France). Thrombomodulin recog- nized by a mouse monoclonal antibody coated ...
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Kaposi's Sarcoma-Associated Herpesvirus Virions Inhibit Interferon Responses Induced by Envelope Glycoprotein gpK8.1
... Microarray analysis performed during early KSHV infection revealed that several IFN-responsive genes were upregulated with rapid kinetics (41). Additionally, upon chemical induction of the KSHV lytic cycle, some of the ...
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Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro
... that recombinant soluble CD4 protein (rsT4) blocks both HIV-1 infection of CD4 bearing lymphocytes and syncytium formation in ...(Recombinant soluble CD4 is designated by ...of ...
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Case Report Successful treatment with recombinant thrombomodulin for B-cell lymphoma-associated hemophagocytic syndrome complicated by disseminated intravascular coagulation
... Recombinant thrombomodulin (rTM) has emerged as a new treatment option for DIC, which inhibits the action of activated Factor V and VIII by activating protein C [10, ...
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