recombinant interleukin
Original Article Effect of human recombinant interleukin-10 on cytokines in adjuvant arthritis rat
... Abstract: Rheumatoid Arthritis (RA) is a kind of chronic systemic autoimmune disease mainly presented as arthrop- athy. Its clinical manifestation includes progressive and symmetry joint destruction, even joint deformity ...
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Fibroblast chemotaxis induction by human recombinant interleukin 4 Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70 88 and 89 122
... Fibroblast Chemotaxis Induction by Human Recombinant Interleukin-4 Identification by Synthetic Peptide Analysis of Two Chemotactic Domains Residing in Amino Acid Sequences 70-88 and 89-1[r] ...
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Administration in vivo of recombinant interleukin 2 protects mice against septic death
... Administration in vivo of recombinant interleukin 2 (rIL-2) to mice induces a polyclonal IgM response. When co-administered with a specific antigen, rIL-2 can enhance concentrations of murine IgM antibodies ...
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Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1 Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163 171
... morphogenesis. Factors controlling the production of HA by fibroblasts in normal and pathological states are not completely understood. In this report we have observed that natural human interleukin (IL-1)1 beta ...
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Multiple biological activities of human recombinant interleukin 1
... monocyte interleukin 1 (IL-1), pI 7 form, was expressed in Escherichia ...the recombinant protein. Homogeneous human recombinant IL-1 (hrIL-1) was tested in several assays to demonstrate the ...
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Stimulation of thrombopoiesis in mice by human recombinant interleukin 6
... human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming ...purified, recombinant ...
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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells
... responses in several different tissues. In these studies we demonstrate that three biological properties of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and collagenase ...
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Recombinant interleukin 12 suppresses the synthesis of immunoglobulin E by interleukin 4 stimulated human lymphocytes
... Previously known as NKSF natural killer cell stimulatory factor or as CLMF cytotoxic lymphocyte maturation factor, IL-12 is a 75-kD heterodimeric glycoprotein displaying several in vitro[r] ...
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Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin 3
... Following our preliminary findings of inhibited ability of splenocytes to produce IL-3 in mice with experimental APLS 16, and given the efficacy of IL-3 in preventing fetal loss in a str[r] ...
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Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... (CSF) recombinant interleukin 3 (IL-3), natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 mouse bone marrow and spleen ...
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Role of interleukin 1 in the pathogenesis of experimental shigellosis
... The effect of human recombinant interleukin-1 receptor antagonist on intestinal inflammation, tissue destruction, and bacterial invasion during experimental shigellosis caused by Shigell[r] ...
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Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease
... of interleukin-5 is restricted to eosinophils, it should be an ideal target to block this response in the lungs of allergic animal models of asthma, and has been studied in several ...to interleukin-5 ...
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Immunostimulatory Effects of Recombinant Erysipelothrix rhusiopathiae Expressing Porcine Interleukin-18 in Mice and Pigs
... Interleukin-18 (IL-18), which was originally called gamma interferon (IFN-␥)-inducing factor, has been shown to play an impor- tant role in innate and acquired immune responses. In this study, attenuated ...
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Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia
... and interleukin-1 (IL-1) prolonged the survival of rats (144 +/- 9 h) in continuous hyperoxia (greater than 99% O2 at 1 atm) when compared with rats injected with boiled TNF/C and boiled IL-1 (61 +/- 2 h), TNF/C ...
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Effect of recombinant human interleukin-7 on Pseudomonas aeruginosa wound infection
... of interleukin-7 (IL-7) biological effects suggests that application of appropriate prepa- rations in clinical practice will stimulate immunity in patients with lymphocytic exhaustion or autoimmune ...of ...
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IL-15 as a potential target in leukemia
... cells. Interleukin 15, a proinflammatory cytokine, induces proliferation and promotes cell survival of human T and B lymphocytes, as well as natural killer ...of Interleukin 15 and its role in the ...
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Recombinant Vaccinia Virus Coexpressing the F Protein of Respiratory Syncytial Virus (RSV) and Interleukin-4 (IL-4) Does Not Inhibit the Development of RSV-Specific Memory Cytotoxic T Lymphocytes, whereas Priming Is Diminished in the Presence of High Levels of IL-2 or Gamma Interferon
... Viruses. rVV were constructed according to standard methods briefly de- scribed below. Two parental VVs were used: strain WR and strain vRB12, a strain WR-derived virus defective for plaque formation (5). The vRB12 virus ...
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Biological properties of recombinant human monocyte derived interleukin 1 receptor antagonist
... coli. Recombinant IL-1ra has 17,000 mol wt and binds to IL-1 receptors on T lymphocytes, synovial cells, and chondrocytes with an affinity nearly equal to that of ...purified recombinant human ...
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Selective induction of immune responses by cytokines coexpressed in recombinant fowlpox virus.
... Here, we describe i the construction of recombinant FPV rFPVs coexpressing the hemagglutinin HA gene of influenza virus A/PR/8 together with the gene for murine interleukin-6 IL-6 or gam[r] ...
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Interleukin-4 Diminishes CD8+ Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo
... (15). Recombinant vaccinia viruses (rVV) expressing RSV antigen M2 (vvM2) or coexpressing M2 and IL-4 (vvM2/ IL-4) were constructed to ensure that IL-4 was present at the site of antigen ...
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