Regioselective synthesis
NBS/AIBN promoted one pot multi component regioselective synthesis of spiro heterobicyclic rings via Biginelli like condensation reaction
... efficient regioselective synthesis of σ symmetric spiro heterobicyclic rings using aldehydes and urea in the presence of cyclic β-diester or β-diamides such as Meldrum’s acid or barbituric acid ...
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Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules
... Herein, we present the regioselective synthesis of the novel series of 2-(bromomethyl)-5-aryl-thiophenes 3a-i, via Suzuki cross-coupling reactions of various aryl boronic acids with 2-br[r] ...
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A highly regioselective synthesis of spiro [oxindole chromanone]pyrrolidines and pyrrolizines through 1,3 dipolarcycloaddition protocol
... highly regioselective synthesis of Spiro[oxindole-chromanone] pyrrolidines and pyrrolizines through 1,3 –dipolar cycloaddition ...the synthesis of dispiroheterocycles using isatin and chromanone ...
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One–Pot Regioselective Synthesis of Heterocyclic Compounds by the Application of Sonogashira Reaction as One of the Steps: A Review
... 14. (a) Kotora, M.; Takahashi, T. In Handbook of Organopalladium Chemistry for Organic Synthesis; Negishi, E., de Meijere, A., Eds.; Wiley-Interscience: New York, 2002; p 973. (b) Siemsen, P.; Livingston, R. C.; ...
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Regioselective Synthesis and Biological Evaluation of 1 Hydroxyl Modified Ailanthinone Derivatives as Antimalarials
... der those reaction conditions. The use of a slight excess of acetic anhydride may have been responsible for pro- moting the hemiketal ring to open followed by acetyla- tion of the resulting C-20 hydroxyl group. Thus, ...
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Regioselective synthesis of N formohydrazide and formyl pyrazole analogs as potent antimicrobial agents
... The transformation of a simple molecule to bioactive molecules of diverse biological applications is a worthwhile contribution in bioorganic chemistry. Formylation is an important process in organic synthesis. ...
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Development of an Amine-Catalyzed Regioselective Synthesis of Pyrroles
... (8) a) Lopchuk, J. M.; Hughes, R. P.; Gribble, G. W. Org. Lett. 2013, 15, 5218; b) For a review, see: Gribble, G. W. in The Chemistry of Heterocyclic Compounds, Oxazoles: Synthesis, Reactions, and Spectroscopy; ...
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Regioselective synthesis of sugar fused dispiropyrrolizidines via intermolecular 1,3 dipolar cycloaddition reaction
... efficient synthesis of not only carbohydrates themselves, but also carbohydrate-containing heterocycles is becoming more and more important in the field of organic chemistry and chemical ...the synthesis of ...
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An Efficient and Novel Regioselective Synthesis of Phosphonylpyrazoles from Vinylazides and Bestmann-Ohira Reagent
... Shader, R. I. Oxa prozin pharmacokinetics in the elderly. Br. J. C. Pharmacol. 1985, 19, 373-378. (d) Culbreath, A. K.; Brenneman, T. B.; Kemerait, Jr. R.C.; Hammes, G. G. Effect of the new pyrazole carboxamide fungicide ...
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A facile and regioselective synthesis of Spiro pyrrolidines and pyrrolizines through 1, 3 dipolar cycloaddition protocol
... Intermolecular 1,3-dipolar cycloaddition reaction of azomethine ylide with olefins are considered as one of the most useful method for the construction of the pyrrolidine structural unit. 1,2 This method is widely used ...
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A Facile and Efficient One Pot Regioselective Synthesis of 2 Hydroxyalkyl Dithiocarbamates under Catalyst Free Conditions
... Dithiocarbamates are a class of fungicides extensively used worldwide on a range of crops mainly due to their efficiency in controlling plant fungal diseases and rela- tively low mammalian acute toxicity [9]. They have ...
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A coupling approach for the generation of α,α bis(enolate) equivalents : regioselective synthesis of gem difunctionalized ketones
... offers extra flexibility over enolate formation by deprotonation. Again, a similar strategy proved viable for the development of a dimethylative coupling using as base either NaHMDS for non- enolizable esters or LiTMP ...
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Ultrasonic irradiation assisted efficient regioselective synthesis of CF3-containing pyrazoles catalyzed by Cu(OTf)2/Et3N
... Also, to find the specific effect of ultrasound on these reactions, all previously mentioned reactions were carried out under the same conditions in the absence of ultrasound irradiation (Table 2). It was observed that ...
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One-pot regioselective synthesis of n-benzoyl 2-amino-3,4-dihydro-3-oxo-2h-1,4-benzothiazines
... Nitrogen-containing heterocycles are undoubtedly one of the most important targets in organic chemistry. They are widely distributed in natural products and in pharmaceutical agents and numerous studies for their ...
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Lipase catalyzed regioselective synthesis of palmitolyglucose ester in ionic liquids
... In this paper, Candida antarctica lipase B (CAL-B) was used as the catalyst for the synthesis of palmitolyglucose ester in ILs, using glucose and palmitic acid vinyl ester as the substrates. The effects of ...
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One pot high yield synthesis of some novel isoxazolidine derivatives using Nmethyl α chloro nitrone in water and their antibacterial activity
... and regioselective synthesis of some novel isoxazolidine derivatives in water using 1,3-Dipolar cycloaddition reaction with N-methyl-α- chloro nitrone [12,13] in a short reaction time and their ...
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Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
... the synthesis of new anticancer agents [31–40], we herein present an efficient regioselective synthesis of novel 4-heteroaryl-pyrazoles, which have not been reported hitherto in a multicompo- nent ...
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“Triazine Derivatives and its Pharmacological Potential - A Review” by Dr. V.M. Mounnissamy, B. Priya, India.
... 23. Wani MY, Bhat AR, Azam A, Choi I, Athar F. Probing the antiamoebic and cytotoxicity potency of novel tetrazole and triazine derivatives. Eur. J. Med. Chem. 48, 2012, 313–320. 24. Miller MS, Pinson J-A, Zheng Z, ...
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Zinc Chloride Catalyzed Regioselective Nitration of Aromatic Hydrocarbons Using Tetrachlorosilane Sodium Nitrate Homogeneous System
... here as a homogeneous nitrating system. The later was used for the efficient mono nitration, in most cases, with high para-regioselectivity. The nitration proceeded smoothly under mild condi- tion, fairly clean and in ...
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Expression and characterization of a novel 1,3-regioselective cold-adapted lipase from Rhizomucor endophyticus suitable for biodiesel synthesis
... Cold-active/adapted lipases show high activity at low temperatures in comparison to the lipases from meso- philes or thermophiles, which have their activities drastically reduced at low temperatures [4]. Recently, ...
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