Regulatory T-cell
B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection
... therapeutics such as rituximab is not typical, the effect of such therapy on Tregs has been sparsely investigated. However, in a study of 21 hepatitis C virus-infected mixed cryoglobulinemia vasculitis patients treated ...
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STAT5 levels in regulatory T-cell subsets
... in T reg homeostasis through stimulation of the STAT5 pathway [4, ...boosting T regs ) in patients with chronic GVHD ...increased T reg blood counts but also induced clinical responses in half of the ...
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Attenuation of Peripheral Regulatory T Cell Suppression of Skin Homing CD8+T Cells in Atopic Dermatitis
... cells have been known to play an important role in the pathogenesis of atopic der- matitis (AD). However, the mechanisms underlying the loss of self-tolerance re- main unclear. Regulatory T cells (Tregs) ...
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Wiskott Aldrich syndrome protein is required for regulatory T cell homeostasis
... self-reactive T cells and thereby play a crucial role in main- tenance of immunologic self tolerance (reviewed in ...naive T cells, enabling Tregs to recognize both self and nonself ...downstream ...
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Review Article The role of butyrate in peripheral regulatory T cell and tolerance induction
... of cell types and dis- ease ...activated T cells and induction of peripheral Tregs, butyrate derivatives could be more effective immune regulators as compared to the traditional im- ...
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The alarmin IL 33 promotes regulatory T cell function in the intestine
... IL-33 is constitutively expressed in epithelial cells at barrier sites 2 where it functions as an endogenous danger signal or alarmin following tissue damage 3 . Recent studies in humans have described high levels of ...
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Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
... Regulatory T cells (Tregs) are a subpopulation of T cells that maintain immunological ...multiple cell types and involved in the pathogenesis of autoimmune ...
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Regulatory T Cell Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation
... Exosomes are small, cup-shaped, secreted membrane vesicles (approximately 50–100 nM in diameter) that are formed by the inward budding of endosomal membranes (1–6). Exosomes are released into the extracellular ...
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Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma
... of T cell specific for HLA-A2 re- stricted epitopes in LMP1 and LMP2 was analyzed by staining with HLA-A2 tetramers assembled with synthetic peptides origin from LMP1 YLQQNWWTL and LMP2 FLYALALLL, ...
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GP96 is a GARP chaperone and controls regulatory T cell functions
... Protein chaperones, known traditionally as hsps, constitute the protein-folding machinery in the cell that plays critical roles in many aspects of cellular function (48, 49). Unfolded protein pre- cursors were ...
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Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... in T cell activation and migration ...efficient T cell ...important T cell transcription factors contain CDK motifs including Tbet, GATA3, RORgt, STAT3, Runx1, Ikaros, DNMT3a, ...
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Abatacept reduces synovial regulatory T cell expression in patients with psoriatic arthritis
... sample t test were used to compare responses to abatacept treatment for clinical measures, synovitis macroscopic scores and immunohis- tological staining scores at 0 vs 2 months, 2 vs 6 months and 0 vs 6 ...on ...
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GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
... were cultured with SpDCs in the presence of anti-CD3 antibody and rIL-2 for 5 days in the presence of indicated cytokines. GATA3 expression was normalized to 100% of the IL-2 alone conditions. (C) STAT3 and T-bet ...
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
... effector T cell response (Bedoya et ...and T-bet were found in the ...effector T cell responses were not significantly affected ...Treg cell both intrathymically and in the ...
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Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice
... tor T cells. Even T cells expressing a single transduced TCR often induce colitis and this system has been used to address the "auto-reactive" repertoire of Treg ...such T cells often ...
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Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer
... Treg cell therapy is fast becoming a viable alternative strategy to combating autoimmunity and transplant ...Treg cell subsets, culminating with re-infusion (Figure 2, Table ...
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Signals Controlling Regulatory T Cell Differentiation and Homeostasis
... that T cells could mediate tolerance, in addition to immunity, to antigenic challenge (Gershon and Kondo, ...a T cell-mediated form of ...suppressor T cells proliferated and complex models ...
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regulatory T cell expression in children with acute bronchial asthma
... Treg cell count but lower expression levels of IL-5 and INF-γ cytokines of the montelukast group sug- gested that montelukast might be effective in up-regulating Treg cells and improving the chronic ...
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The control of CD4+CD25+Foxp3+regulatory T cell survival
... that T reg cells consume cytokines from conventional CD4 T cells, and in the proc- ess, suppress them ...of T reg cells in the absence of cytokines showed condensed nuclei and mem- brane blebbing, ...
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Impact of IL-27 on regulatory T cell responses
... While IL-27 has not been used in any human therapies to date, the studies above illustrate the potential impact of IL-27 in clinical settings. One consideration for the use of any cytokine treatment is the relatively ...
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