Regulatory T cell depletion
Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV 1 and SIV infections
... the depletion of T ...to depletion of naive T cells in HIV-1 infected patients and SIV-infected rhesus ...The T regulatory cell response to immune activation increased ...
12
Regulatory B cell production of IL 10 inhibits lymphoma depletion during CD20 immunotherapy in mice
... lymphoma depletion during immunotherapy involves at least 2 mechanisms: direct CD20 mAb targeting of tumor cells for depletion by monocytes and enhanced tumor depletion by the removal of endogenous ...
14
Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury
... Animals were deeply anesthetized with isoflurane, sacri- ficed by cervical dislocation, decapitated, brains carefully dissected, and processed for histology and immunohisto- chemistry essentially as described [46]. Brain ...
14
B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection
... B cell-deficient and anti-CD20-treated animals, B cells have been reported to have both positive and negative effects on the size and function of the Treg subset (reviewed in references 33 and ...or ...
13
jix547.pdf
... 6. Regulatory T-cell (Treg) depletion combined with suppressive combination antiretroviral therapy (cART) leads to a reduction of human immunodeficiency virus type 1 (HIV-1) reservoirs in ...
13
Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology
... Regulatory T cells (Treg), a component of adaptive immunity, are well known for their immunosuppressive roles and their ability to maintain the balance between the immunological and pathological ...their ...
26
The CII specific autoimmune T cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis
... specific T cells and neutralized the FTY720 inhibition of autoimmune ...enhanced regulatory function of Treg cells are a major mechanism by which FTY720 inhibits the development of autoimmune arthritis in ...
16
Enhancement of vaccine mediated antitumor immunity in cancer patients after depletion of regulatory T cells
... experiments, cell viability was determined through MTT assays (A) or 7-AAD staining ...20:1. Cell proliferation was significantly inhibited when isolated CD4 + /CD25 high cells were added to PBMCs at a 1:1 ...
12
The role of regulatory T cells in antigen induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+T cells
... mBSA, and analyzed for proliferative response and cytokine production. As expected from the increased DTH reaction, the proliferative response to mBSA was signifi- cantly increased in cells from CD25-depleted mice as ...
11
Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults
... normal T cell signal transduction in the early stages of HIV infection when viral load is high, thus providing another mechanism for the impairment of ...in regulatory T cells and an over- ...
10
Immunotherapy of Murine Retrovirus-Induced Acquired Immunodeficiency by CD4 T Regulatory Cell Depletion and PD-1 Blockade
... CD4 T helper effector cells are required for MAIDS induction and progression of viral ...CD8 T cells are not needed for viral pathogenesis, but rather, are essential for protection from disease in resistant ...
12
Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
... Changes in Treg numbers have been implicated in both the prevention and the enhancement of the progression of type 1 diabetes (T1D) in the NOD mouse model. Depletion of Tregs leads to a significantly faster onset ...
128
Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
... Sortilin-1 was recently identified as a major regulator of plasma cholesterol in a genome-wide association study (31). It acts intracellularly to modulate VLDL secretion by binding apoB-con- taining particles in the ...
13
Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
... with cell surface antibodies (anti-CD3, CD4 and CD8; Pharmingen, BD Biosciences, CA, USA), resuspended in 1% paraformalde- hyde (Sigma) and tested for fluorescence using a Becton Dickinson FACSCalibur with ...
10
CD4 T Cell Depletion at the Cervix during HIV Infection Is Associated with Accumulation of Terminally Differentiated T Cells
... systemic T cells to CD45RA ⫹ CCR7 ⫺ TD cells that are no longer fit for development and survival (21, ...of T cells at the mucosa. While the causal relationship between HIV load, T cell ...
9
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis
... This work and the work of others indicate that proteins that influence the structural order and composition of lipid rafts sig- nificantly impact TCR signaling and hence T cell differentiation and ...
12
Baicalin, a natural compound, promotes regulatory T cell differentiation
... 293 T cells (Chinese Academy of Sciences, Shanghai, China) were maintained in Dulbecco ’ s modified Eagle ’ s medium (Hyclone, Logan, UT) and transiently transfected with pZIGF using Lipofectamine (Invitrogen, San ...
7
Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts
... demonstrate regulatory T cell function, they share as a drawback the fact that such function occurs under lymphopenic conditions, where T cell homeostasis is dramatically changed by ...
7
GP96 is a GARP chaperone and controls regulatory T cell functions
... Our study strongly suggests that the fundamental role of mLTGF-β in Tregs is to confer immune tolerance in vivo. Sev- eral questions remain unanswered. First, it is unclear why TGF-β on the surface of Tregs is so ...
12
A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion
... disrupt T-cell ...for T-cell homeostasis (27), by preventing the dephosphorylation of NFAT (nuclear factor of activated T cells), thereby blocking its downstream transcriptional ...
15