Regulatory T (Treg) cells
Regulatory T cells (Treg) and Their Roles in Immune System with Respect to Immunopathological Disorders
... Regulatory T cells (Tregs) are a specialized, phenotypi- cally, and functionally distinct, subpopulation of T cells that modulate immune response, thereby maintaining homeo- stasis and ...
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Therapeutic Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of inflammatory and Th1/Th17 Responses and Induction of Regulatory T Cells
... of T cells and transmits an inhibitory signal to T cells through interaction with CD80/CD86, which are members of the B7 family ...+ T cells were augmented, especially in the ...
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
... specific T cell proliferation in a Notch dependent manner, indicating regulatory ...of regulatory DC ...of T cells and ...a Treg population, but in turn induce tDC which generate ...
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Increased activated regulatory T cell subsets and aging Treg-like cells in multiple myeloma and monoclonal gammopathy of undetermined significance: a case control study
... T cells could be divided into three different subpopula- tions: activated Treg cells (aTregs), resting Treg cells (rTregs) and non-suppressive Treg cells ...
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The Toll-like Receptor 2 (TLR2)-related Immunopathological Responses in the Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
... residential cells within the ...non-lymphoid cells result in the induction of inflammatory responses during ...Th1/Th17 cells, downregulation of regulatory T (Treg) cells, ...
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The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome
... induces T cell apoptosis, T cell en- ergy, and suppress T cell function ...dendritic cells or macrophage thus induc- ing differentiation of T Reg /suppressor T cells ...
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Original Article Regulatory function of TH17/Treg ratios in the children suffering from adenoidal hypertrophy with complications
... that regulatory T cells and Th17 ones play a pivotal role in the pathogenesis of allergic rhinitis ...and Treg cells showed significant changes in children with ...of Treg ...
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Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... of regulatory T cells ...CD4+ T cells transduced with a Foxp3-CDK motif mutant have increased function compared to cells transduced with wild-type Foxp3 as measured by induction ...
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Intrinsic predisposition of naïve cystic fibrosis T cells to differentiate towards a Th17 phenotype
... epithelial cells [22,23], but later studies confirmed that CFTR is also expressed in lymphocytes ...Moreover, T cell clones derived from CF subjects show a defective c-AMP regulated chloride current, ...
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
... in Treg cells did not result in systemic immune activation, but did lead to the development of colitis and increased lung allergic inflammation, suggesting that production of IL-10 is required for ...
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Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos
... the regulatory T cell (Treg), responder CD4+ T helper cell (Tresp), CD8+ cytotoxic T lymphocytes (CTL), and natural killer (NK) cells were ...of regulatory T cell ...
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Autophagy enhances mesenchymal stem cell-mediated CD4+ T cell migration and differentiation through CXCL8 and TGF-β1
... + T cells ...recruit T leukomonocytes, monocytes, ...immune regulatory cytokines such as transforming growth factor (TGF)-β1, IL-12, and prostaglandin E2, which play key roles in MSC-mediated ...
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The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy
... 1. The varied immunity of the selected experimental subjects may play a part in the inconsistency; 2. Diffe- rent sampling time may also be an important factor. Sampling from subjects may happen before treatment, after ...
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High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients
... of Treg and NK ...in T cell ...of T cells, such as activation of naive T cells, cytokine secretion of effect T cells, and apoptosis of activated T ...
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Increased production of soluble CTLA 4 in patients with spondylarthropathies correlates with disease activity
... 18. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett ...
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CD28 co-stimulation in T-cell homeostasis: a recent perspective
... antigen-presenting cells (APCs), in particular dendritic cells, are not only uniquely able to capture, transport, and (cross-)present microbial antigens but are also equipped with pattern recognition ...
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Variation of Peripheral Th17/Treg Imbalance in Patients with Idiopathic Membranous Nephropathy After Cyclosporin a Treatment: A Prognostic Marker of Idiopathic Membranous Nephropathy
... whereas Treg% and TGF-β level were down-regulated in the peripheral blood of IMN ...whereas Treg frequency and TGF-β level increased in the effective group (all ...Th17/ Treg imbalance, which is ...
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Y27, a novel derivative of 4 hydroxyquinoline 3 formamide, prevents the development of murine systemic lupus erythematosus like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice
... + Treg cell isolation kit was obtained from Miltenyi Biotec GmbH, Bergisch Gladbach, ...mouse Treg cell staining kit came from eBioscience, San Diego, CA USA, and con- tained anti-mCD16/CD32, fluorescein ...
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Agammaglobulinaemia despite terminal B-cell differentiation in a patient with a novel LRBA mutation
... Hypogammaglobulinaemia is common but not universal with LRBA deficiency. Indeed, as illustrated in our case, an increase in immunoglobulin can be observed early in the natural history. The pathophysiology of immune ...
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Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
... of Treg HLA-DR positive in controls compared to 22% in AA patients (P � ...LAG-3+ cells in the Treg pool (Fig 1B and S1 ...CD39+ Treg cells resident in skin, we analysed the ...
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