Repeated dose toxicity
ACUTE AND 28 DAY REPEATED DOSE TOXICITY OF AVERRHOA CARAMBOLA LEAVES ETHANOLIC EXTRACT IN RODENTS
... a dose level of 2000 mg kg- 1 bw on the acute and with a graded dose levels from 250, 500, 1000 and 2000 mg kg- 1 bw for 28-day repeated-dose toxicity test in Wistar ...the ...
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Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
... systemic toxicity of nanosilver is, however, relatively ...systemic toxicity of 20 nm silver nanoparticles (Ag-NP) was studied in a 28-day repeated-dose toxicity study in ...maximum ...
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PRECLINICAL ACUTE AND REPEATED DOSE TOXICITY OF PUERARIA TUBEROSA (PTWE) ON CHARLES FOSTER RATS
... Repeated Dose Toxicity: The repeated dose toxicity study was carried out. Here those animal prepared described above and randomly divided into different group having five animal. ...
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Evaluation of Acute and Repeated Dose Toxicity of the Polyherbal Formulation Linkus Syrup in Experimental Animals
... any toxicity even at a dose of 1 or 5 g/kg as compared to the ...In repeated dose toxicity determination, the test drug was given at three differ- ent doses ...maximum dose of ...
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A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
... Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to ...addressing repeated dose toxicity could ...
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Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intravenous 28 days repeated dose toxicity study
... a dose-dependent ...same dose. Although the relation between immune toxicity and characterizations is not com- pletely clear, several of the mentioned characteristics may also influence the immune ...
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Development, characterization, efficacy and repeated dose toxicity of nanoemulsified ethanolic extract of Enicostemma littorale in Streptozotocin-induced diabetes rats.
... Alginate nanocapsules of ethanolic extract of Enicostemma littorale (NEL) were prepared by emulsification, cross linking with calcium chloride and solvent removal. Based on total phenol content the loading efficiency of ...
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Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data
... The SA having ID = 5 reports the naphthalene ring, a polycyclic aromatic hydrocarbon, known as an environ- mental contaminant, and classified as a potential human carcinogen [36]. It is widely used commercially in the ...
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A 13 Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague Dawley Rats
... For dose selection, we considered the result of previously reported repeated toxicity study (Study ...weeks repeated toxicity; 0, 500, 1000, 2000 mg/kg) [10] where no significant ...
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TOXICOLOGICAL EVALUATION OF AN INFUSION OF Bidens pilosa
... apparent toxicity during the time that the experiment lasted and in sentinel group during the post administration ...the repeated dose toxicity study (28 days) ...
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Acute and 26 Week Repeated Oral Dose Toxicity Study of UP446, a Combination of Scutellaria Extract and Acacia Extract in Rats
... 26-week repeated oral dose toxicity study in SD ...a dose of 5000 mg/kg. In 26-week repeated oral dose toxicity study, UP446 at doses of 500, 1000 and 2000 mg/kg/day were ...
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REPEATED DOSE TOXICOLOGICAL STUDIES OF HYDROALCOHOLIC EXTRACT OF LANNEA KERSTINGII ENGL AND K KRAUSE (ANACARDIACEAE) AND IDENTIFICATION OF TOXICITY MECHANISMS
... ABSTRACT: Lannea kerstingii Engl. & K. Krause stem bark (Anacardiaceae) is used to treat anaemia, malaria, infections and Burili ulcer. The antioxidant, antihelmintic and trypanocidal properties have been ...
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Journal of Applied Pharmaceutical Science
... oral toxicity (AOT), subchronic toxicity, and mutagenic potential of glycosides based standardized fenugreek (Trigonella foenum graecum ...(90-day repeated dose) toxicity and ...
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Preclinical Validation of Anti-Anxiety, Anti-Depressant and Anti-Cataleptic Activity of Classical Siddha Drug Sadhakuppai Chooranam in Animal Model
... Male Sprague Dawley rats (200-250gm) are housed in groups of six exposed to 12 hr light/dark cycle with free access to food and water.Locomotion study – Test compound or vehicle are administered orally 1 hr or i.p. 30 ...
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Genotoxicity, acute and subchronic toxicity studies of nano liposomes of Orthosiphon stamineus ethanolic extract in Sprague Dawley rats
... of repeated exposure of OS leaves extracts ...oral toxicity tests were conducted in Sprague Dawley (SD) rats according to the OECD guidelines, and for the first time, the genotoxicity of OS-EL was ...
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Assessment of acute, 14 day, and 13 week repeated oral dose toxicity of Tiglium seed extract in rats
... changes in other liver function markers such as ALT, AST (hepatocellular damage marker) [50, 51], and TG (fatty liver marker) [52] were observed in TS extract treatment groups, including decreased AST in males of 500 ...
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Preclinical Safety Evaluation of Rasa Karpoora Kuligai
... Siddhars were the great scientist in ancient times. They used nano technology for the preparation of Medicines. These Nano particles have beneficial properties that can be used to improve drug delivery system. Target ...
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Scientific Validation of Siddha Drug “Kadukkai Vadagam” for its Bronchodilator, Anti-Histamine and Anti-Oxidant properties in Rodents
... substance was administered. Three Female animals are used for each group. The dose level of 3, 30,300 and 2000 mg/kg body weight was administered stepwise. After the substance has been administered, food was ...
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ORAL TOXICITY STUDY OF VERNONIA CINEREA AQUEOUS LEAF EXTRACT IN SWISS ALBINO MICE
... Medicinal plants are invaluable in health care system of each community. They possess bioactive secondary metabolites that protect the plants. These bio compounds have medicinal properties which could prevent and treat ...
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A Toxicity study on Puttru Pathangam
... Animals are observed individually after dosing at least once during the first 30 minutes, periodically during the first 24 hours, with special attention given during the first 4 hours, and daily thereafter, for a total ...
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