Replication cycle - virion assembly and budding
The Replication Cycle of Varicella-Zoster Virus: Analysis of the Kinetics of Viral Protein Expression, Genome Synthesis, and Virion Assembly at the Single-Cell Level
... DNA replication compartments started between 4 and 6 h, involved recruitment of ORF29 to putative IE62 prereplication sites, and resulted in large globular nuclear compartments where newly synthesized viral DNA ...
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Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly
... poxvirus replication cycle and the large number of essential viral proteins present a rich array of additional untapped targets for the discovery of new antipox- viral ...viral replication and ...
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Zika Virus NS2A Mediated Virion Assembly
... to virion assembly ...the virion assembly site where coordinated cleavage of C-prM-E initiates genomic RNA and C protein encapsidation followed by prM/E envelopment and virion ...
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The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly
... In infected cells, besides the 42-kDa monomers, dimers and trimers were detected under nonreducing conditions, whereas only trimeric GP41 forms were selectively in- corporated into BVs or ODVs. Mutations of all five ...
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Human Cytomegalovirus pUS24 Is a Virion Protein That Functions Very Early in the Replication Cycle
... a virion protein and virions produced by US24-deficient viruses exhibit a block to the human cytomegalovirus replication cycle after viral DNA reaches the nucleus and before immediate-early mRNAs are ...
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A Functional Link between RNA Replication and Virion Assembly in the Potyvirus Plum Pox Virus
... Altogether, these results highlight the importance of coupling encapsidation to other viral processes to secure a successful infection. IMPORTANCE Viruses of the family Potyviridae are among the most dangerous threats ...
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Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding.
... of replication in MDCK cells without added neuraminidase, indicating that the virus particles contained in these aggregates were ...entry, replication, or assembly in cell culture or in ...
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Analysis of Assembly and Budding of Lujo Virus
... In addition, LUJV Z expression also reduced the number of mCherry-positive cells to approximately one-third of that of the control. Similarly, both the PSAP-AAAA and YREL-AAEL muta- tions reduced the number of ...
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REVIEW ARTICLE DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
... sensitive budding yeast cdc28 mutant, Cdc28 appears dispensable for premeiotic S phase but is required for meiotic nuclear divisions ...DNA replication. In budding yeast, G1 cyclin (Cln)-deficient ...
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ORF3 Protein of Hepatitis E Virus Is Not Required for Replication, Virion Assembly, or Infection of Hepatoma Cells In Vitro
... in virion production in vivo ...production, virion morphogenesis, or virion infectivity in vitro, one function may be to promote viral egress, perhaps by interaction with cellular proteins or path- ...
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Vaccinia Virus A6 Is Essential for Virion Membrane Biogenesis and Localization of Virion Membrane Proteins to Sites of Virion Assembly
... in virion membrane ...viral replication (28). A14 glycosylation was increased, however, when virion membrane biogenesis was blocked, presumably because A14 was retained or diverted to the ER in the ...
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Host cytoskeleton in respiratory syncytial virus assembly and budding
... Cytoskeleton in RSV infection RSV is known to interact with the cytoskeleton in sev- eral ways and at various stages throughout its life cycle. In addition to transcriptional regulation, the cytoskel- eton is also ...
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Global Replication-Independent Histone H4 Exchange in Budding Yeast
... chromatin assembly in ...chromatin assembly and disassembly have not been detected by the current study and may reflect the differences in our experimental ...Alternatively, budding yeast may be able ...
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The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release.
... genome replication and the assembly of infectious virus ...genome replication, the roles of domains II and III are less well ...genome replication, pointing to a key role for the C terminus of ...
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Intracellular assembly and budding of the Murine Leukemia Virus in infected cells
... Gag is sufficient to assemble vesicular VLPs The Gag polyprotein is the basic component in the mak- ing of virion particles at the plasma membrane. Indeed, released VLPs can be obtained upon cellular expression of ...
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Accumulation of Virion Tegument and Envelope Proteins in a Stable Cytoplasmic Compartment during Human Cytomegalovirus Replication: Characterization of a Potential Site of Virus Assembly
... stages of virus assembly were likely completed within the cy- toplasm. Our results were consistent with these processes occurring within a single compartment, since pp150 and a number of other tegument and ...
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Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly
... complement replication, was to a large extent excluded from foci containing NS5A produced from the NS3-5B ...which replication-defective mutations can be ...of replication by expressing only ...
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Reconstitution Of Regulated Eukaryotic Dna Replication With Purified Budding Yeast Proteins
... for replication initiation and their relative order of assembly at eukaryotic replication origins have advanced over time, comparatively little is known about the mechanism of Mcm2-7 helicase ...DNA ...
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CiteSeerX — DNA replication stress is a determinant of chronological lifespan in budding yeast
... DNA replication stress downstream of deregulated nutrient signaling as an important determinant of chronological aging in budding ...reduces replication stress, as well as age- dependent DNA damage ...
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The Role of Replication Bypass Pathways in Dicentric Chromosome Formation in Budding Yeast
... First, we show that genes in the error-free postreplication repair (PRR) pathway prevent fusion of inverted repeats, while genes in the translesion branch have no detectable role. Second, we found that siz1 mutants, ...
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