resistance to thyroid hormone
Thyroid hormone resistance syndrome Inhibition of normal receptor function by mutant thyroid hormone receptors
... Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant ...free thyroid hormone levels and partial resistance to thyroid hormone at the ...
9
Growth and Development in a Child With Resistance to Thyroid Hormone and Ectopic Thyroid Gland
... to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid ...both thyroid gland ectopy and resistance to thyroid hormone and, thus, a ...
6
Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma
... to thyroid hormone (RTH) is a syndrome of reduced tissue responsiveness to thyroid ...the thyroid hormone receptor beta (THRB) ...papillary thyroid carcinoma ...a thyroid ...
5
Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)alpha 1 and TR alpha 2: clinical, biochemical, and genetic analyses of three related patients
... with resistance to thyroid hormone β and we have identifi ed a TRβ mutation (ala317val) analogous to the Ala263Val mutation in TRα1 that localises to one of these hotspots (fi gure ...reduced ...
9
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine guanine rich areas of the thyroid hormone receptor beta gene Analysis of 15 families
... Generalized resistance to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid ...human thyroid hormone receptor beta (TR beta) gene ...
9
Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... Generalized resistance to thyroid hormone (GRTH) is a syndrome characterized by impaired tissue responsiveness to thyroid ...the hormone binding domain of the thyroid ...
8
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin
... to thyroid hormone (RTH) is a dominantly inherited condition with affected individuals harboring mutations in the β isoforms of the thyroid hormone receptor (TR) ...circumstances, ...
10
Resistance to thyroid hormone accompanied by atrial fibrillation
... to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to ...
5
New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone
... Generalized resistance to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant ...major thyroid hormone receptor (TR) ...
8
Differential expression of mutant and normal beta T3 receptor alleles in kindreds with generalized resistance to thyroid hormone
... Thyroid hormone resistance (THR) is primarily an autosomal dominant inherited disease characterized by resistance of pituitary and peripheral tissues to the action of thyroid ...
6
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone Identification of thirteen novel mutations in the thyroid hormone receptor beta gene
... generalized disorder (GRTH) or associated with thyrotoxic features, indicating possible selective pituitary resistance (PRTH). 20 GRTH and 9 PRTH cases, sporadic or dominantly inherited, were analyzed. Affected ...
11
A base mutation of the C erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance Molecular heterogeneity in two other kindreds
... Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly linked to one of the two thyroid hormone ...
9
Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report
... the referral, the patient had complained of fatigue and a goiter and had consulted a family practitioner. A thyroid function test showed TSH < 0.1 μIU/mL, FT3 of 2.70 pg/ mL, and FT4 of 3.6 ng/dL. The doctor ...
5
A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
... in her serum. Shortly afterwards, several adult male and female individuals were identified that harbored frame- shift/premature stop mutations within the TRα1 LBD [14, 45]. These patients also had additional features in ...
11
Partial Target Organ Resistance to Thyroid Hormone
... serum thyroid hormone levels (thyroxine [T 4 ] ...serum thyroid- stimulating hormone (TSH) levels (average ...there thyroid abnormalities either in the parents or six ...
8
Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature
... Her thyroid functions and fetal ultrasound morphology were monitored every 1–4 weeks (more frequently during the initial and last month), and revealed no ...maternal thyroid hormones and patient preference, ...
5
UNDERSTANDING HYPOTHYROIDISM IN AYURVEDA .......
... Hypothyroidism refers to any state that results in a deficiency of thyroid hormone, including hypothalamic or pituitary disease and generalized tissue resistance to thyroid hormone [r] ...
9
Growth Hormone Responses to Thyroid Hormone in the Neonatal Rat: RESISTANCE AND ANAMNESTIC RESPONSE
... The most salient and novel findings of the present study are a thyroid hormone-independent accumulation of GH in rat pituitary during early neonatal life; b insensitivity of GH to T3 dur[r] ...
7
Thyroid hormone and anti-apoptosis in tumor cells
... that thyroid hormone is anti-apoptotic in tumor cells and in certain non-tumor ...host thyroid hormone could contribute to chemotherapeutic resistance ...that thyroid ...
9
Mechanisms of thyroid hormone action
... to thyroid hormone, but enhanced peripheral tissue sensitivity, as the animals were euthyroid despite lower circulating thyroid hormone ...the resistance phe- notype seen in that model ...
10