Response to pressure overload
βIV Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload
... An aspect of our study relevant to this discussion is the focus on local control of a subpopulation of CaMKII/STAT3 at the cardio- myocyte intercalated disc membrane. Interestingly, our findings in the qv 3J mouse align ...
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RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload
... in response to pressure overload and also did not exhibit induction of the cardiac “fetal” gene ...cardiac response to acute ventricular pressure overload and the cardiac ...
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Molecular Cardiology. Bone Marrow Derived Cells Are Involved in the Pathogenesis of Cardiac Hypertrophy in Response to Pressure Overload
... Bone marrow (BM)– derived cells are known to have a broad potential to differentiate into various cells in response to physiological cues. It is generally thought that cardiac hypertrophy arises from hypertrophy ...
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α1 Adrenergic receptors prevent a maladaptive cardiac response to pressure overload
... J Clin Invest. 2006;116(4):1005-1015. https://doi.org/10.1172/JCI22811. An a 1 -adrenergic receptor (a 1 -AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart ...
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Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.
... in response to either ascending aortic constriction ...in response to AoC differs between adult (9-mo-old) and old (18-mo-old) ...in response to AoC only in the adult ...
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Age related differences in the expression of proto oncogene and contractile protein genes in response to pressure overload in the rat myocardium
... T Takahashi, … , W Grossman, S Izumo J Clin Invest. 1992;89(3):939-946. https://doi.org/10.1172/JCI115675. Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of ...
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Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
... to pressure overload in vivo in ...moderate-intensity pressure overload, whereas cardiomyocyte-specific Klf5 deletion did not alter the hypertrophic ...the response to pressure ...
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Pivotal role of cardiomyocyte TGF β signaling in the murine pathological response to sustained pressure overload
... in response to pressure overload (25), whereas myocyte-specific TAK1 overex- pression stimulates hypertrophy and heart failure ...against pressure overload stress in hearts with induced ...
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Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
... in response to pressure overload–induced injury; therefore, these processes are widely considered to be promising therapeutic ...following pressure overload, fibrob- lasts were not ...
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CHIP protects against cardiac pressure overload through regulation of AMPK
... metabolic response to pressure overload by direct regulation of the catalytic α subunit of ...cardiac pressure overload in Chip –/– mice resulted in robust hypertrophy and decreased ...
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Original Article Apigenin inhibits pressure overload-induced cardiac hypertrophy
... adaptive response to pathological stimulus, sustained hypertrophy is deleterious and long-term decompensation may lead to congestive heart failure, malignant arrhythmia or even sudden death, which is associated ...
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Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy
... 4. Discussion 4.1 Rictor/mTORC2 is implicated in the response to pressure overload The main objective of the present study was to elucidate the function of mTORC2 in the heart. Our experiments ...
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Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
... We believe these findings facilitate both the increased fibrosis and exaggerated hypertrophic response observed in systemic rassf1A KO mouse hearts in response to pressure overload. ...
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Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
... against pressure overload at 1 week after TAC, as evidenced by the levels of cardiomyocyte apoptosis, Nppb expression, CaMK2d phosphorylation, and intersti- tial myocardial ...
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Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?
... ing pressure overload (Figure 1C), localized proliferation of these fibroblasts (without substantial migration) and their persis- tence, rather than de novo epicardial and endothelial activation or ...
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Apoptosis in pressure overload induced heart hypertrophy in the rat
... after pressure-induced overload were cardiomyocytes which were much more numerous than in sham-operated ...of pressure overload, several genes, including hsp70, and the oncogenes c- myc , c- ...
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Puerarin attenuates pressure overload-induced cardiac hypertrophy
... blood pressure and decreased systolic function and diastolic function, animals treated with puerarin demonstrated normalization of these hemo- dynamic parameters including EDP, dP/dt max, and dP/dt min ( ...
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Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice
... the pressure overload-induced hypertro- phic heart, there still exist different ...attenuate pressure overload-induced cardiac hypertrophic responses [23, 24] whereas other studies recognized ...
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Original Article Cinnamaldehyde attenuates pressure overload-induced cardiac hypertrophy
... The possible mechanisms by which cinnamal- dehyde regulates cardiac hypertrophy remain unclear. It is generally accepted that biome- chanical stress induced by pressure overload triggers a variety of signal ...
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Original Article Evodiamine attenuates pressure overload-induced cardiac hypertrophy
... alleviated pressure overload- induced cardiomycyte apoptosis To explore the role of evodiamine in cardiomyo- cyte apoptosis, we stained hearts with TUNEL ...by pressure overload was ...
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