RET gene
Original Article The correlation analysis of RET gene polymorphism with papillary thyroid carcinoma
... in RET gene exon ...and gene sequencing were performed to con- firm their polymorphism distribution of rs1799939 in RET ...in gene frequency of rs1799939 site distributions (G/G, G/A ...
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Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma
... the RET locus according to the GENCODE v26 ...on RET gene, a further indicative of somatic retrocopies, similar to our previous approaches ...
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Heterozygous p.S811F RET gene mutation associated with renal agenesis, oligomeganephronia and total colonic aganglionosis: a case report
... In Ret-deficient mice, inactivation of Ret in the late fetal period leads to absence of neural components in the lower large intestine, as also seen with GFRα1 de- fects, implicating reduced Ret ...
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Original Article RET gene mutations identified by exome sequencing in a multiple endocrine neoplasia type 2A
... of RET proto-oncogene, and no mutation other than RET has ever been identified so far [14, ...of RET proto- oncogene, among which 87% was caused by the mutation of codon 634 with the most com- mon ...
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Preliminary study shows novel variant detected in the screening of RET gene in Malaysian patients with Hirschsprung’s disease
... of RET kinase activity ...the RET G691S where together with K666E, it enhances the transforming activity which results in increased downstream signaling of the RET gene ...
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The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co receptor
... the RET and GFR receptors are present in invertebrates but are thought to function independently of each other, with GFRs operating in conjunction with Fas2/NCAM rather than with a soluble ligand (Kallijärvi et ...
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Exon skipping in the RET Gene encodes novel isoforms that differentially regulate RET Protein signal transduction
... spermatogenesis. RET encodes a transmembrane receptor that is 20 exons long and produces two known protein isoforms differing in C-termi- nal amino acid composition, referred to as RET9 and ...as RET ⌬E3 ...
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The RET/PTC RAS BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
... the RET or TRKA tyrosine kinase receptors and oncogenic activation of the RAS or BRAF ...genes. RET encodes the tyrosine kinase recep- tor of growth factors belonging to the glial-derived neurotrophic ...
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Apatinib inhibits cellular invasion and migration by fusion kinase KIF5B-RET via suppressing RET/Src signaling pathway
... in RET inhibitors to find the therapeutic potential as targeted drugs tailored for RET fusion-positive patients ...Although RET-inhibiting TKIs provide new therapeutic potential in ...
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The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies
... RET-G691S polymorphism expression/penetrance was assessed in two FMTC families carrying the germline activating mutation RET -S891A. Family 1 is an extremely large family with members distributed in several ...
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Original Article RET mutation and expression in small cell lung cancer
... Abstract: RET is a paradigm of a single gene that causes different types of human neuroendocrine cancers and non-small cell lung cancer, but the role for RET in the development of SCLCs was however ...
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EGF Induced RET Inhibitor Resistance in CCDC6 RET Lung Cancer Cells
... to RET inhibitors sunitinib, E7080, vandetanib, and sorafenib by acti- vating bypass survival ...to RET inhibitors by ...in RET-fusion patient-derived tumors, combination of RET and EGFR TKIs ...
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KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas
... KIF5B- RET fusion gene–transformed cells into nude mice resulted in the development of the tumor in vivo, indicating the fu- sion gene’s oncogenic potential ...harboring RET gene rearrange- ...
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<p><em>KIF5B-RET</em> fusion gene and its correlation with clinicopathological and prognosis features in lung cancer: a meta-analysis</p>
... Methods: The PubMed, Google Scholar, Wiley Online, SpringerLink and Chinese National Knowledge Infrastructure databases were searched to identify the eligible studies. The associa- tion of the occurrence of ...
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Identification and characterization of RET fusions in advanced colorectal cancer
... by RET fusion kinase ...express RET fusion ...to RET-directed therapies in thyroid cancer and ...anti- RET kinase activity such as vandetanib, lenvatinib, ponatinib, and carbozantinib are at ...
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Cloning and molecular characterisation of the murine 'c-ret' locus
... Reporter gene activity was first observed within a subset of cells at the proximal end of the primitive streak in early ...Z gene can be observed in the mesenchymal cells of the limb buds ...Z gene ...
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The role of activated RET in papillary tumour morphogenesis
... between RET/PTC rearrangements and primary peritoneal ...f RET/PTC may directly influence the inflammation within these ...note, RET/PTC protein expression produces a strong inflammatory response in ...
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Pericytes limit tumor cell metastasis
... recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing the microvessel wall. To directly address whether pericyte ...
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Identification of a novel partner gene, KIAA1217 , fused to RET Functional characterization and inhibitor sensitivity of two isoforms in lung adenocarcinoma
... date, RET specific inhibitors have not been fully validated in clinical trials and there is no established therapy for RET fusion-positive patients [39, ...the RET/papillary thyroid carcinoma (PTC) ...
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Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype
... the ret tyrosine-kinase ...of ret oncogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic ...the ret oncogene in 33 (19%) of 177 papillary ...
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