Retinal Neovascularization
Original Article miR-132 promotes retinal neovascularization under anoxia and reoxygenation conditions through up-regulating Egr1, ERK2, MMP2, VEGFA and VEGFC expression
... Retinal neovascularization (RNV) is regarded as a pathological angiogenesis in ...prematurity, retinal vein occlusions, and age-related macu- lar degeneration [1, ...tractional retinal ...
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Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats
... decreased with increasing time in the 5 µ g/mL netrin-1 group. Furthermore, the quantitative results clearly dem- onstrated that we found more type IV + strands in the rats injected with 0.1 µ g/mL netrin-1 than in the ...
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Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo
... in retinal neovascularization pathogenesis research ...the retinal vasculature, which stimulates proangiogenic factors and results in abnormal neovascularization ...in retinal ...
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Inhibitory effect of Samul tang on retinal neovascularization in oxygen induced retinopathy
... Although VEGF is widely recognized as an ideal target for regulating angiogenesis therapies [29, 30], recent evidence has suggested that SDF-1 is a key player in ischemic retinopathies, such as proliferative retinopathy ...
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Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
... The retinal vascular morphology was observed using adenosine diphosphatase and number counting using hematoxylin and eosin-stained ...pathological neovascularization and nonperfused area when compared with ...
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VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
... pathological neovascularization (Fig. 5). In our model of pathological retinal neovascularization, CTL- mediated cellular immunity is thought to play a critical role in the defense against the ...
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Original Article The role of ω-3 PUFAs in affecting retinal neovascularization by regulating microglia phenotype
... Oxygen-induced retinal neovascular disease is a common blinding eye disease in ...regulating retinal neovascularization remains poorly ...diet. Retinal microglia (MG) were detected by ...
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The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
... groups. Retinal neovascularization (RNV) was qualitatively analyzed with ADPase staining and quantitatively analyzed by counting neovascular endothelial cell nuclei at postnatal day 17 when RNV reached a ...
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Formononetin, an active compound of <em>Astragalus membranaceus</em> (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathway
... the retinal neovascularization (NV) of diabetic ...on retinal NV is limited so ...hypoxia-induced retinal NV and the possible related ...
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Possibility of enhanced risk of retinal neovascularization in repeated blood donors: blood donation and retinal alteration
... induced retinal hypoxia, and its subsequent possible effects on retinal angiogenesis and/or retinal neovascularization in humans have been overlooked to ...and retinal alteration ...
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Manipulation of autophagy: a novelly potential therapeutic strategy for retinal neovascularization
... autophagy in RVECs under physical hypoxia was associ- ated with enhanced cell migration and capillary formation. Besides, angiogenesis of RVECs was weakened in the hypoxia+ 3-MA group when compared with the control ...
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Knockout of insulin and IGF 1 receptors on vascular endothelial cells protects against retinal neovascularization
... in retinal neovascu- larization following disruption of insulin receptor in endothelial cells, which is accompanied by suppression of these vascular mediators, further implicates the role of these endothelial ...
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Deficiency of Neuropilin 2 Suppresses VEGF-Induced Retinal Neovascularization
... Several lines of evidence suggest that VEGF plays a critical role in the development of retinal NV, but the mechanisms of VEGF sig- naling are complex and poorly understood. Most studies utilizing in vitro testing ...
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Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy
... of retinal revascularization and tuft ...of neovascularization where they were aggregated in and around the neovascular tufts on the vitreal surface of the retina ...
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Efficacy of patterned scan laser in treatment of macular edema and retinal neovascularization
... Results: Follow-up was 5.9 ± 2.6 months for group 1 and 5.9 ± 4.0 months for group 2. In group 1, 9/28 eyes required a second treatment for remaining edema. BCVA was stable or better in 66% (14/21) and average central ...
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Long-term follow-up of herpetic non-necrotizing retinopathy with occlusive retinal vasculitis and neovascularization
... initial neovascularization and a good response to anti- viral ...early retinal neovascularization, which has not been described previously ...
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CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
... pathological retinal angiogenesis in ...in retinal neovascularization (Figure ...the retinal vascular network (Supplemental Figure 2) or in the gross morphology of the retina (Supplemental ...
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Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy
... air–raised P14 mice in vascular endothelial cells, the ganglion cell layer, the INL, and the outer nuclear layer, as described previously (36). We identified the nonvas- cular cells expressing VEGFR2 in the nerve fiber ...
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Retinal changes in visceral leishmaniasis by retinal photography
... the retinal images using VAMPIRE (Vessel Assessment and Measurement Platform for Images of the REtina; ver- sion ...established, retinal photographs from 30 healthy individuals recruited in a separate study ...
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Overload and neovascularization of shoulder tendons in volleyball players
... moderate neovascularization (insufficient to show the newly formed vessels at power-Doppler) to gross increases exceeding 50% of extension of the vessels in the tendon ...
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